pI: 7.6692 |
Length (AA): 67 |
MW (Da): 7769 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 64 | 3h0g (J) | 1 | 64 | 73.00 | 0 | 1 | 1.62942 | 1.48 |
1 | 64 | 1twf (J) | 1 | 65 | 66.00 | 0 | 1 | 1.64142 | 0.56 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127691)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G11475 | DNA-directed RNA polymerases II, IV and V subunit 10 |
Arabidopsis thaliana | AT1G61700 | DNA-directed RNA polymerase subunit 10-like protein |
Babesia bovis | BBOV_III004290 | RNA polymerases N / 8 kDa subunit family protein |
Brugia malayi | Bm1_00170 | DNA-directed RNA polymerase II 7.6 kDa polypeptide, putative |
Caenorhabditis elegans | CELE_Y37E3.3 | Protein RPB-10 |
Cryptosporidium parvum | cgd4_3260 | putative DNA-directed RNA polymerases I, II, and III 8.3 kda polypeptide |
Dictyostelium discoideum | DDB_G0272036 | RNA polymerase I core subunit |
Drosophila melanogaster | Dmel_CG13628 | CG13628 gene product from transcript CG13628-RA |
Echinococcus granulosus | EgrG_000213750 | dna directed rna polymerases i ii and iii |
Entamoeba histolytica | EHI_122780 | DNA-directed RNA polymerase subunit N, putative |
Echinococcus multilocularis | EmuJ_000213750 | |
Giardia lamblia | GL50803_14413 | DNA-directed RNA polymerase RPB10 |
Homo sapiens | ENSG00000177700 | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa |
Leishmania braziliensis | LbrM.25.1280 | DNA-directed RNA polymerase ii |
Leishmania braziliensis | LbrM.13.0920 | DNA-directed RNA polymerase ii 8.2 Kd polypeptide, putative |
Leishmania donovani | LdBPK_131020.1 | DNA-directed RNA polymerase ii 8.2 Kd polypeptide, putative |
Leishmania donovani | LdBPK_251350.1 | DNA-directed RNA polymerase I subunit RPB10, putative |
Leishmania infantum | LinJ.25.1350 | DNA-directed RNA polymerase ii |
Leishmania infantum | LinJ.13.1020 | DNA-directed RNA polymerase ii 8.2 Kd polypeptide, putative |
Leishmania major | LmjF.25.1315 | DNA-directed RNA polymerase ii |
Leishmania major | LmjF.13.1120 | DNA-directed RNA polymerase ii 8.2 Kd polypeptide, putative |
Leishmania mexicana | LmxM.25.1315 | DNA-directed RNA polymerase ii |
Leishmania mexicana | LmxM.13.1120 | DNA-directed RNA polymerase ii 8.2 Kd polypeptide, putative |
Loa Loa (eye worm) | LOAG_00477 | hypothetical protein |
Mus musculus | ENSMUSG00000038489 | polymerase (RNA) II (DNA directed) polypeptide L |
Neospora caninum | NCLIV_062340 | DNA-directed RNA polymerase subunit N (EC 2.7.7.6), related |
Oryza sativa | 4351671 | Os12g0180400 |
Oryza sativa | 4349985 | Os11g0194800 |
Plasmodium berghei | PBANKA_0805400 | DNA-directed RNA polymerases I, II, and III subunit RPABC5, putative |
Plasmodium falciparum | PF3D7_0708100 | DNA-directed RNA polymerases I, II, and III subunit RPABC5, putative |
Plasmodium knowlesi | PKNH_0106700 | DNA-directed RNA polymerases I, II, and III subunit RPABC5, putative |
Plasmodium vivax | PVX_087935 | DNA-directed RNA polymerase II 8.2 kDa polypeptide, putative |
Plasmodium yoelii | PY00134 | Putative RNA polymerase II subunit Rpb10 |
Saccharomyces cerevisiae | YOR210W | DNA-directed RNA polymerase core subunit RPB10 |
Schistosoma japonicum | Sjp_0058640 | ko:K03007 DNA-directed RNA Polymerase II subunit L, putative |
Schistosoma mansoni | Smp_008440 | DNA-directed rna polymerase II subunit n |
Schmidtea mediterranea | mk4.007927.00 | |
Schmidtea mediterranea | mk4.013094.01 | |
Schmidtea mediterranea | mk4.017853.01 | |
Schmidtea mediterranea | mk4.002525.07 | |
Schmidtea mediterranea | mk4.009851.03 | |
Trypanosoma brucei gambiense | Tbg972.3.1000 | DNA-directed RNA polymerase subunit, putative |
Trypanosoma brucei | Tb927.11.3705 | DNA-directed RNA polymerases I, II, and III subunit RPABC5, putative |
Trypanosoma brucei | Tb927.3.1250 | DNA-directed RNA polymerase I subunit RPB10 |
Trypanosoma cruzi | TcCLB.511881.14 | DNA-directed RNA polymerase I subunit RPB10, putative |
Trypanosoma cruzi | TcCLB.509453.40 | DNA-directed RNA polymerase I subunit RPB10, putative |
Trypanosoma cruzi | TcCLB.503821.10 | DNA-directed RNA polymerase I subunit, putative |
Trypanosoma cruzi | TcCLB.509683.24 | RNA-binding protein RBP10, putative |
Toxoplasma gondii | TGME49_217560 | DNA-directed RNA polymerase II RPB10 |
Theileria parva | TP02_0237 | DNA-directed RNA polymerase subunit N, putative |
Trichomonas vaginalis | TVAG_434510 | DNA-directed RNA polymerase II, subunit N, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.1250 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.1250 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.1250 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.3.1250 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y37E3.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
YOR210W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_217560 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.