Detailed view for Bm1_00180

Basic information

TDR Targets ID: 242830
Brugia malayi, DnaJ chaperonine
Source Database / ID:  GenBank

pI: 6.9412 | Length (AA): 390 | MW (Da): 43385 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00226   DnaJ domain
PF00684   DnaJ central domain
PF01556   DnaJ C terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0051082   unfolded protein binding  
GO:0031072   heat shock protein binding  
GO:0005524   ATP binding  
GO:0009408   response to heat  
GO:0006457   protein folding  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 70 2lo1 (A) 2 71 81.00 0 1 1.30889 -2.29
3 68 2och (A) 3 68 76.00 0 1 1.32063 -3.01
7 339 4j80 (A) 7 259 35.00 0 1 0.804246 1.3
104 332 1nlt (A) 111 337 41.00 0 1 0.991979 0.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126883)

Species Accession Gene Product
Arabidopsis thaliana AT5G22060   chaperone protein dnaJ 2
Arabidopsis thaliana AT3G44110   chaperone protein dnaJ 3
Babesia bovis BBOV_IV009890   DnaJ chaperone, putative
Brugia malayi Bm1_12110   DnaJ protein
Brugia malayi Bm1_00180   DnaJ chaperonine
Candida albicans CaO19.8136   likely heat-shock protein (DnaJ) similar to S. cerevisiae YDJ1 (YNL064C)
Candida albicans CaO19.506   likely heat-shock protein (DnaJ) similar to S. cerevisiae YDJ1 (YNL064C)
Caenorhabditis elegans CELE_F39B2.10   Protein DNJ-12
Caenorhabditis elegans CELE_T05C3.5   Protein DNJ-19
Cryptosporidium hominis Chro.80434   DNAJ domain protein
Cryptosporidium parvum cgd8_3770   DNAJ like chaperone
Dictyostelium discoideum DDB_G0280037   heat shock protein
Drosophila melanogaster Dmel_CG8863   DnaJ-like-2
Echinococcus granulosus EgrG_000101800   dnaJ subfamily A
Entamoeba histolytica EHI_079720   DnaJ family protein
Entamoeba histolytica EHI_073780   DNAJ homolog subfamily A member 2, putative
Entamoeba histolytica EHI_151260   DnaJ family protein
Echinococcus multilocularis EmuJ_000101800   dnaJ subfamily A
Giardia lamblia GL50803_9808   Chaperone protein DnaJ
Homo sapiens ENSG00000140403   DnaJ (Hsp40) homolog, subfamily A, member 4
Homo sapiens ENSG00000069345   DnaJ (Hsp40) homolog, subfamily A, member 2
Homo sapiens 3301   DnaJ (Hsp40) homolog, subfamily A, member 1
Leishmania braziliensis LbrM.27.2610   heat shock protein DNAJ, putative
Leishmania braziliensis LbrM.21.0550   DnaJ protein, putative
Leishmania donovani LdBPK_272350.1   heat shock protein DNAJ, putative
Leishmania donovani LdBPK_210550.1   DnaJ protein, putative
Leishmania infantum LinJ.21.0550   DnaJ protein, putative
Leishmania infantum LinJ.27.2350   heat shock protein DNAJ, putative
Leishmania major LmjF.21.0490   DnaJ protein, putative
Leishmania major LmjF.27.2400   heat shock protein DNAJ, putative
Leishmania mexicana LmxM.27.2400   heat shock protein DNAJ, putative
Leishmania mexicana LmxM.21.0490   DnaJ protein, putative
Loa Loa (eye worm) LOAG_08462   DnaJ protein
Loa Loa (eye worm) LOAG_00474   DnaJ chaperonine
Loa Loa (eye worm) LOAG_07485   hypothetical protein
Mus musculus ENSMUSG00000031701   DnaJ (Hsp40) homolog, subfamily A, member 2
Mus musculus ENSMUSG00000028410   DnaJ (Hsp40) homolog, subfamily A, member 1
Mus musculus ENSMUSG00000032285   DnaJ (Hsp40) homolog, subfamily A, member 4
Neospora caninum NCLIV_055170   DnaJ domain containing protein, related
Oryza sativa 4333580   Os03g0648400
Oryza sativa 4336584   Os04g0549600
Oryza sativa 4330201   Os02g0656500
Oryza sativa 4334359   Os03g0787300
Plasmodium berghei PBANKA_0610900   HSP40, subfamily A, putative
Plasmodium falciparum PF3D7_1437900   HSP40, subfamily A
Plasmodium knowlesi PKNH_0424600   HSP40, subfamily A, putative
Plasmodium vivax PVX_084650   DnaJ domain containing protein
Plasmodium yoelii PY02476   DnaJ homolog
Saccharomyces cerevisiae YNL064C   type I HSP40 co-chaperone YDJ1
Schistosoma japonicum Sjp_0016830   ko:K09502 DnaJ homolog, subfamily A, member 1, putative
Schistosoma mansoni Smp_035200.1   hsp40 subfamily A members 124
Schistosoma mansoni Smp_035200.4   hsp40 subfamily A members 124
Schistosoma mansoni Smp_035200.3   hsp40 subfamily A members 124
Schistosoma mansoni Smp_035200.2   hsp40 subfamily A members 124
Schmidtea mediterranea mk4.023390.00  
Schmidtea mediterranea mk4.005212.00  
Schmidtea mediterranea mk4.002651.02  
Schmidtea mediterranea mk4.000960.00  
Schmidtea mediterranea mk4.018720.00  
Schmidtea mediterranea mk4.042143.00  
Trypanosoma brucei gambiense Tbg972.10.2780   chaperone protein DNAj, putative
Trypanosoma brucei gambiense Tbg.972.2.3190   chaperone protein DNAj, putative
Trypanosoma brucei Tb927.2.5160   chaperone protein DnaJ, putative
Trypanosoma brucei Tb927.10.2290   chaperone protein DnaJ, putative
Trypanosoma congolense TcIL3000_2_1270   chaperone protein DnaJ, putative
Trypanosoma cruzi TcCLB.511367.138   chaperone DNAJ protein, putative
Trypanosoma cruzi TcCLB.511627.110   heat shock protein DNAJ, putative
Toxoplasma gondii TGME49_311240   DnaJ family chaperone, putative
Theileria parva TP01_0706   dnaJ protein, putative
Trichomonas vaginalis TVAG_066950   DNAj/HSP40, putative
Trichomonas vaginalis TVAG_150550   DNAj/HSP40, putative
Trichomonas vaginalis TVAG_305730   chaperone protein DNAj, putative

Essentiality

Bm1_00180 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.5160 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.2.5160 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.2.5160 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.2.5160 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.2290 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.2290 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.2290 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.2290 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F39B2.10 Caenorhabditis elegans embryonic lethal wormbase
TGME49_311240 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens DnaJ (Hsp40) homolog, subfamily A, member 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_00180 (Brugia malayi), DnaJ chaperonine
Title for this comment
Comment