Detailed view for Bm1_33300

Basic information

TDR Targets ID: 242926
Brugia malayi, MBOAT family protein
Source Database / ID:  GenBank

pI: 7.7777 | Length (AA): 327 | MW (Da): 37474 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03062   MBOAT, membrane-bound O-acyltransferase family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Wnt signaling pathway (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133309)

Species Accession Gene Product
Brugia malayi Bm1_33300   MBOAT family protein
Caenorhabditis elegans CELE_T07H6.2   Protein MOM-1
Drosophila melanogaster Dmel_CG6205   porcupine
Echinococcus granulosus EgrG_000111210   protein cysteine N palmitoyltransferase
Echinococcus granulosus EgrG_000224000   zinc finger protein
Echinococcus multilocularis EmuJ_000111210   protein cysteine N palmitoyltransferase
Echinococcus multilocularis EmuJ_000224000   zinc finger protein
Homo sapiens ENSG00000102312   porcupine homolog (Drosophila)
Loa Loa (eye worm) LOAG_07740   MBOAT family protein
Mus musculus ENSMUSG00000031169   porcupine homolog (Drosophila)
Schistosoma japonicum Sjp_0043730   ko:K00181 porcupine, putative
Schistosoma mansoni Smp_133180.2   zinc finger protein
Schmidtea mediterranea mk4.001047.00   Probable protein-cysteine N-palmitoyltransferase porcupine

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus porcupine homolog (Drosophila) Compounds References
Homo sapiens porcupine homolog (Drosophila) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1735 0.4173 0.8602
0.3273 0.9999 1
0.3273 0.9999 1
0.026 0.739 0.739
0.0578 0.3056 1
0.124 0.7485 1
0.4464 0.5254 0.5252
0.2247 0.597 1
0.0242 0.3742 0.5878
0.3094 0.4042 0.8983
0.0299 0.5224 0.2404
0.3105 0.4167 1
0.3062 0.9228 1
0.2218 0.6567 1
0.0248 0.3375 0.4138
0.445 0.6354 0.6354
0.3835 0.7797 1
0.1735 0.4173 0.8602
0.0782 0.5965 0.9932
0.1735 0.4173 0.8602
0.0739 0.4351 0.5953
0.3282 0.4185 1
0.0989 0.7461 1
0.3823 0.6094 1
0.0247 0.285 0.4853
0.9141 1 1
0.124 0.7485 1
0.073 0.7926 1
0.0789 0.9003 1
0.4401 0.5297 1
0.3013 0.3882 0.7155
0.0488 0.4869 0.4869
0.6696 0.5236 1
0.4412 0.6514 1
0.149 0.6058 1
0.1226 0.5012 1
0.1486 0.6067 1
0.4469 0.5246 1
0.2779 0.6841 0.7793
0.4436 0.2782 0.2782
0.3282 0.4185 1
0.1736 0.407 1
0.0726 0.4345 0.7513
0.0966 0.3932 1
0.1231 0.9085 1
0.0972 0.5967 0.8314
0.3273 0.9999 1
0.0245 0.3344 0.6683
0.0244 0.3024 0.4881
0.4135 0.8588 1
0.3047 0.9279 1
0.2741 0.6285 1
0.0494 0.34 0.6234
0.2525 0.7475 1
0.4361 0.5515 1
0.0046 0.5 0.5
0.0966 0.3932 1
0.2779 0.6841 0.7793
0.4464 0.5254 0.5252
0.0721 0.7071 0.9649
0.2531 0.9765 1
0.0926 0.6007 1
0.1243 0.585 1
0.1735 0.4173 0.8602
0.0244 0.4914 0.5033
0.3094 0.4042 0.8983
0.1735 0.4173 0.8602
0.0482 0.5156 0.977
0.1735 0.4173 0.8602
0.3134 0.6357 1
0.4601 0.7875 1
0.1511 0.3528 0.7484
0.3085 0.3733 1
0.0855 0.6873 1
0.1994 0.4824 1
0.0241 0.3302 0.4535
0.3764 0.8451 1
0.3506 0.614 1
0.0042 0.3061 0.3061
0.4412 0.6514 1
0.0988 0.2957 0.6492
0.0244 0.6898 0.4614
0.0483 0.4208 0.6986
0.2504 0.6064 1
0.0299 0.307 0.9474
0.4412 0.6514 1
0.3013 0.3882 0.7155
0.3102 0.6279 1
0.2479 0.3206 1
0.3013 0.3882 0.7155
0.4289 0.6162 0.6179
0.4412 0.6514 1
0.2248 0.3919 1
0.254426 1 0.5
0.4694 0.5919 1
0.057 0.7036 1
0.0245 0.2779 0.5237
0.2497 0.7949 0.7949
0.2188 0.9219 0.9219
0.3812 0.3205 1
0.3019 0.9175 1
0.0299 0.3611 1
0.0299 0.9107 1
0.4101 0.8473 1
0.3013 0.3882 0.7155
0.0239 0.4694 0.4689
0.0168 0.2981 0.3372
0.3094 0.4042 0.8983
0.0555 0.3231 1
0.0885 0.6003 1
0.4412 0.6514 1
0.2263 0.9 1
0.1504 0.3527 0.7509
0.3085 0.3733 1
0.3094 0.4042 0.8983
0.1736 0.4068 1
0.1964 0.9279 0.9279
0.3355 0.7902 1
0.0299 0.2776 0.5203
0.1251 0.9939 1
0.0731 0.7602 0.764
0.0769 0.7524 0.8075
0.0975 0.3981 1
0.0789 0.9003 1
0.0246 0.855 1
0.4178 0.8295 1
0.3037 0.934 1
0.3812 0.3205 1
0.1735 0.4173 0.8602
0.1736 0.4064 1
0.0244 0.9002 0.9002
0.0974 0.6414 0.6414
0.1987 0.8032 1
0.0299 0.6485 0.6758
0.4412 0.6514 1
0.4361 0.5515 1
0.4694 0.5919 1
0.4601 0.7875 1
0.6696 0.5236 1
0.1735 0.4173 0.8602
0.1741 0.4104 0.8131
0.6696 0.5236 1
0.2751 0.3738 1
0.2751 0.3738 1
0.0258 0.2982 1
0.4464 0.5254 0.5252
0.1 0.2958 0.6503
0.097 0.3932 1
0.0726 0.445 1
0.1964 0.9279 0.9279
0.2497 0.7949 0.7949
0.3093 0.9582 1
0.0782 0.5965 0.9932
0.1735 0.4173 0.8602
0.0738 0.2951 0.9636
0.288063 1 1
0.0728 0.8893 1
0.4412 0.6514 1
0.1002 0.2947 0.5902
0.4464 0.5254 0.5252
0.0024 0.3982 0.3982
0.9141 1 1
0.4144 0.8221 1
0.2525 0.7475 1
0.0885 0.6003 1
0.024 0.5572 0.9189
0.1736 0.4064 1
0.4412 0.6514 1
0.0486 0.2665 1
0.6696 0.5236 1
0.3047 0.9279 1
0.3129 0.9341 1
0.6696 0.5236 1
0.3506 0.614 1
0.1243 0.585 1
0.0782 0.5965 0.9932
0.097 0.3995 1
0.1133 0.4374 1
0.1239 0.3639 1
0.3088 0.6291 1
0.057 0.7036 1
0.3764 0.8451 1
0.3105 0.6277 1
0.3094 0.4042 0.8983
0.3094 0.4042 0.8983
0.3854 0.778 1
0.022 0.2682 0.2664
0.445 0.6354 0.6354
0.4412 0.6514 1
0.2188 0.9219 0.9219
0.2751 0.3738 1
0.024 0.2929 0.4537
0.2525 0.7475 1
0.1736 0.4064 1
0.3105 0.4167 1
0.1218 0.459 0.8058
0.2247 0.597 1
0.0727 0.7065 0.7357
0.3764 0.8451 1
0.3853 0.9091 1
0.1736 0.4064 1
0.3117 0.7535 1
0.2497 0.7949 0.7949
0.0726 0.2986 1
0.4435 0.758 1
0.0299 0.6444 1
0.1735 0.4173 0.8602
0.0241 0.2945 1
0.3058 0.6132 1
0.1482 0.4549 1
0.4436 0.2782 0.2782
0.4412 0.6514 1
0.9141 1 1
0.4412 0.6514 1
0.0747 0.2954 0.5343
0.2751 0.3738 1
0.0698 0.8405 1
0.0022 0.3737 0.3737
0.3853 0.9091 1
0.1736 0.4064 1
0.3013 0.3882 0.7155
0.3013 0.3882 0.7155
0.6696 0.5236 1
0.4347 0.9042 1
0.029 0.303 0.4033
0.1735 0.4173 0.8602
0.0242 0.3151 0.3495
0.3865 0.7865 1
0.4412 0.6514 1
0.4694 0.5919 1
0.3882 0.9577 1
0.0975 0.7996 0.7994
0.1736 0.4064 1
0.0024 0.3925 0.3925
0.4401 0.5297 1
0.0978 0.8442 0.8438
0.3105 0.4167 1
0.4135 0.8588 1
0.0495 0.342 0.7685
0.2479 0.3206 1
0.0966 0.3932 1
0.0243 0.2814 0.2797
0.4289 0.6162 0.6179
0.1218 0.459 0.8058
0.3019 0.6049 1
0.1736 0.4064 1
0.2504 0.6064 1
0.2474 0.9918 1
0.4464 0.5254 0.5252
0.9141 1 1
0.1735 0.4173 0.8602
0.024 0.662 0.9096
0.3046 0.9213 1
0.0578 0.3056 1
0.0596 0.3745 0.6771
0.2247 0.597 1
0.6696 0.5236 1
0.3094 0.4042 0.8983
0.073 0.7926 1
0.4412 0.6514 1
0.3355 0.7902 1
0.0244 0.3149 0.3557
0.0299 0.4144 1
0.057 0.7036 1
0.0257 0.311 0.3497
0.4412 0.6514 1
0.3282 0.4185 1
0.139613 0.817637 1
0.1735 0.4173 0.8602
0.4412 0.6514 1
0.445 0.6354 0.6354
0.2751 0.3738 1
0.3058 0.6132 1
0.4412 0.6514 1
0.0977 0.8068 0.8062
0.0486 0.5261 0.58
0.445 0.6354 0.6354
0.3864 0.7821 1
0.0043 0.293 0.293
0.9141 1 1
0.0503 0.293 0.6975
0.2762 0.6323 1
0.1484 0.5982 1
0.6123 0.4573 1
0.4178 0.8265 1
0.2248 0.3919 1
0.0247 0.285 0.4853
0.148 0.4482 1
0.1481 0.8752 1
0.024 0.2821 1
0.1208 0.7438 1
0.4161 0.8216 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_33300 (Brugia malayi), MBOAT family protein
Title for this comment
Comment