Detailed view for Bm1_02530

Basic information

TDR Targets ID: 243043
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 9.0293 | Length (AA): 604 | MW (Da): 69876 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 12

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03155   ALG6, ALG8 glycosyltransferase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016758   transferase activity, transferring hexosyl groups  
GO:0005789   endoplasmic reticulum membrane  

Metabolic Pathways

N-Glycan biosynthesis (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 83 2qlc (A) 57 120 33.00 0.29 0.17 0.312538 0.74
63 148 5f86 (A) 277 349 29.00 0.81 0.02 -0.106416 2.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129590)

Species Accession Gene Product
Arabidopsis thaliana AT2G44660   probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
Brugia malayi Bm1_02530   hypothetical protein
Candida albicans CaO19.9228   oligosaccharyl transferase
Candida albicans CaO19.1659   oligosaccharyl transferase
Caenorhabditis elegans CELE_C08H9.3   Protein C08H9.3, isoform B
Cryptosporidium hominis Chro.10240   hypothetical protein
Cryptosporidium parvum cgd1_2100   hypothetical protein
Dictyostelium discoideum DDB_G0275261   dolichyl-phosphate-glucose alpha-1,3-glucosyltransferase
Drosophila melanogaster Dmel_CG4542   xiantuan
Echinococcus granulosus EgrG_001195500   dolichyl pyrophosphate Glc1Man9GlcNAc2
Echinococcus multilocularis EmuJ_001195500   dolichyl pyrophosphate Glc1Man9GlcNAc2
Homo sapiens ENSG00000159063   ALG8, alpha-1,3-glucosyltransferase
Loa Loa (eye worm) LOAG_05127   hypothetical protein
Mus musculus ENSMUSG00000035704   asparagine-linked glycosylation 8 (alpha-1,3-glucosyltransferase)
Neospora caninum NCLIV_057630   dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3- glucosyltransferase, putative
Oryza sativa 4330363   Os02g0688500
Saccharomyces cerevisiae YOR067C   dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase
Schistosoma japonicum Sjp_0216040   ko:K03849 alpha-1,3-glucosyltransferase, putative
Schistosoma mansoni Smp_151520   dolichyl glycosyltransferase
Schmidtea mediterranea mk4.002540.03   Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
Schmidtea mediterranea mk4.016645.00   Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
Toxoplasma gondii TGME49_314730   ALG6, ALG8 glycosyltransferase family protein

Essentiality

Bm1_02530 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C08H9.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_C08H9.3 Caenorhabditis elegans larval arrest wormbase
CELE_C08H9.3 Caenorhabditis elegans sterile wormbase
TGME49_314730 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

2 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_02530 (Brugia malayi), hypothetical protein
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