pI: 4.9428 |
Length (AA): 908 |
MW (Da): 102759 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
74 | 444 | 4hdo (A) | 421 | 726 | 25.00 | 0 | 1 | 0.42359 | 0.51 |
597 | 901 | 3fm0 (A) | 18 | 328 | 42.00 | 0 | 1 | 0.884003 | -0.87 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127906)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G32990 | WD40 domain-containing protein |
Arabidopsis thaliana | AT2G26060 | cytosolic iron-sulfur protein assembly protein CIA1 |
Babesia bovis | BBOV_III001050 | WD domain, G-beta repeat containing protein |
Brugia malayi | Bm1_22720 | hypothetical protein |
Candida albicans | CaO19.11769 | similar to proteins with WD (WD-40) repeats |
Candida albicans | CaO19.4293 | similar to proteins with WD (WD-40) repeats |
Caenorhabditis elegans | CELE_Y18D10A.9 | Protein Y18D10A.9 |
Cryptosporidium hominis | Chro.10254 | WD40 protein Ciao1 |
Cryptosporidium parvum | cgd1_2230 | WD40 protein Ciao1 |
Dictyostelium discoideum | DDB_G0269728 | WD40 repeat-containing protein |
Drosophila melanogaster | Dmel_CG12797 | CG12797 gene product from transcript CG12797-RA |
Echinococcus granulosus | EgrG_000949100 | cytosolic iron sulfur protein assembly |
Entamoeba histolytica | EHI_044480 | WD domain containing protein |
Echinococcus multilocularis | EmuJ_000949100 | cytosolic iron sulfur protein assembly |
Giardia lamblia | GL50803_17550 | Transducin/WD-40 repeat protein family |
Homo sapiens | 9391 | cytosolic iron-sulfur assembly component 1 |
Leishmania braziliensis | LbrM.10.0110 | hypothetical protein, conserved,WD-repeat containing protein |
Leishmania donovani | LdBPK_100090.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.10.0090 | hypothetical protein, conserved,WD-repeat containing protein |
Leishmania major | LmjF.10.0110 | hypothetical protein, conserved,WD-repeat containing protein |
Leishmania mexicana | LmxM.10.0110 | hypothetical protein, conserved,WD-repeat containing protein |
Loa Loa (eye worm) | LOAG_02246 | WD repeat domain 39 |
Mus musculus | ENSMUSG00000003662 | cytosolic iron-sulfur protein assembly 1 |
Neospora caninum | NCLIV_056580 | hypothetical protein |
Oryza sativa | 4342847 | Os07g0252000 |
Plasmodium berghei | PBANKA_0607800 | cytosolic iron-sulfur protein assembly protein 1, putative |
Plasmodium falciparum | PF3D7_1209400 | cytosolic iron-sulfur protein assembly protein 1, putative |
Plasmodium knowlesi | PKNH_1309300 | cytosolic iron-sulfur protein assembly protein 1, putative |
Plasmodium vivax | PVX_084500 | cytosolic iron-sulfur protein assembly protein 1, putative |
Plasmodium yoelii | PY07576 | WD40 protein Ciao1-related |
Plasmodium yoelii | PY00229 | hypothetical protein |
Saccharomyces cerevisiae | YDR267C | Cia1p |
Schistosoma japonicum | Sjp_0108880 | IPR001680,WD-40 repeat;IPR011046,WD40-like,domain-containing |
Schistosoma japonicum | Sjp_0210650 | Protein CIAO1, putative |
Schistosoma mansoni | Smp_018400 | hypothetical protein |
Schmidtea mediterranea | mk4.001822.00 | Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog |
Trypanosoma brucei gambiense | Tbg972.8.3580 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.8.3860 | cytosolic iron-sulfur protein assembly 1 |
Trypanosoma congolense | TcIL3000_8_3740 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.503905.40 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.507705.20 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_313280 | WD domain, G-beta repeat-containing protein |
Theileria parva | TP03_0735 | hypothetical protein, conserved |
Theileria parva | TP03_0734 | hypothetical protein |
Trichomonas vaginalis | TVAG_350560 | WD repeat domain, putative |
Trichomonas vaginalis | TVAG_441510 | WD repeat containing protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.3860 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.3860 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.3860 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.3860 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y18D10A.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
YDR267C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0607800 | Plasmodium berghei | Essential | plasmo |
TGME49_313280 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.