Detailed view for Bm1_43740

Basic information

TDR Targets ID: 243300
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 9.5334 | Length (AA): 659 | MW (Da): 77413 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01757   Acyltransferase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016747   transferase activity, transferring groups other than amino-acyl groups  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
509 568 3odj (A) 66 122 28.00 0.79 0.01 0.113147 2.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128123)

Species Accession Gene Product
Brugia malayi Bm1_43740   hypothetical protein
Brugia malayi Bm1_43465   Temporarily assigned gene name protein 40
Caenorhabditis elegans CELE_F09B9.1   Protein OAC-14
Caenorhabditis elegans CELE_C06B3.2   Protein OAC-3
Caenorhabditis elegans CELE_F52F10.4   Protein OAC-32
Caenorhabditis elegans CELE_W06G6.1   Protein OAC-53
Caenorhabditis elegans CELE_C31A11.5   Protein OAC-6
Caenorhabditis elegans CELE_F36G9.12   Protein OAC-20
Caenorhabditis elegans CELE_F52F10.3   Protein OAC-31
Caenorhabditis elegans CELE_C08B11.4   Protein NRF-6
Caenorhabditis elegans CELE_C31A11.1   Protein OAC-5
Caenorhabditis elegans CELE_C31A11.7   Protein OAC-7
Dictyostelium discoideum DDB_G0272769   hypothetical protein
Drosophila melanogaster Dmel_CG5892   CG5892 gene product from transcript CG5892-RB
Drosophila melanogaster Dmel_CG16723   CG16723 gene product from transcript CG16723-RB
Drosophila melanogaster Dmel_CG14205   CG14205 gene product from transcript CG14205-RA
Drosophila melanogaster Dmel_CG3106   CG3106 gene product from transcript CG3106-RB
Drosophila melanogaster Dmel_CG10183   CG10183 gene product from transcript CG10183-RB
Drosophila melanogaster Dmel_CG32645   CG32645 gene product from transcript CG32645-RB
Drosophila melanogaster Dmel_CG14219   CG14219 gene product from transcript CG14219-RA
Drosophila melanogaster Dmel_CG10182   CG10182 gene product from transcript CG10182-RA
Drosophila melanogaster Dmel_CG42329   CG42329 gene product from transcript CG42329-RA
Drosophila melanogaster Dmel_CG33337   CG33337 gene product from transcript CG33337-RB
Drosophila melanogaster Dmel_CG13325   CG13325 gene product from transcript CG13325-RB
Drosophila melanogaster Dmel_CG14204   CG14204 gene product from transcript CG14204-RB
Loa Loa (eye worm) LOAG_01188   hypothetical protein
Loa Loa (eye worm) LOAG_01594   hypothetical protein
Mus musculus ENSMUSG00000046610   O-acyltransferase like
Onchocerca volvulus OVOC10620  
Schistosoma japonicum Sjp_0028800   Nose resistant to fluoxetine protein 6 precursor, putative
Schistosoma japonicum Sjp_0210210   Nose resistant to fluoxetine protein 6 precursor, putative
Schistosoma japonicum Sjp_0028590   Triosephosphate isomerase, putative
Schistosoma mansoni Smp_124340   hypothetical protein

Essentiality

Bm1_43740 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C08B11.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_F09B9.1 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_43740 (Brugia malayi), hypothetical protein
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