Detailed view for Bm1_25090

Basic information

TDR Targets ID: 243365
Brugia malayi, Subtilase family protein
Source Database / ID:  GenBank

pI: 6.9933 | Length (AA): 905 | MW (Da): 100480 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00082   Subtilase family
PF12580   Tripeptidyl peptidase II

Gene Ontology

Mouse over links to read term descriptions.
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 856 3lxu (X) 152 1023 33.00 0 1 1.23916 0.42
2 863 3lxu (X) 153 1102 27.00 0 1 1.16659 0.64
85 356 2gko (A) 34 296 25.00 0 1 0.535852 0.07
257 350 3i6s (A) 476 578 40.00 0.053 0.3 0.210167 0.86
301 367 4h6w (A) 217 286 31.00 0 0.86 0.391333 -0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131469)

Species Accession Gene Product
Arabidopsis thaliana AT4G20850   tripeptidyl peptidase II
Brugia malayi Bm1_25090   Subtilase family protein
Caenorhabditis elegans CELE_F21H12.6   Protein TPP-2
Drosophila melanogaster Dmel_CG3991   tripeptidyl-peptidase II
Echinococcus granulosus EgrG_000166800   peptidase s8 s53 subtilisin kexin sedolisin
Echinococcus multilocularis EmuJ_000166800   Peptidase S8 S53, subtilisin kexin sedolisin
Homo sapiens ENSG00000134900   tripeptidyl peptidase II
Loa Loa (eye worm) LOAG_08100   subtilase
Mus musculus ENSMUSG00000041763   tripeptidyl peptidase II
Oryza sativa 4330237   Os02g0664300
Schistosoma japonicum Sjp_0041220   hypothetical protein
Schistosoma japonicum Sjp_0037280   hypothetical protein
Schistosoma japonicum Sjp_0037290   ko:K01280 tripeptidyl-peptidase II [EC3.4.14.10], putative
Schistosoma mansoni Smp_131220   tripeptidyl-peptidase II (S08 family)
Schmidtea mediterranea mk4.011451.00  
Schmidtea mediterranea mk4.011569.01  
Schmidtea mediterranea mk4.017437.02  
Schmidtea mediterranea mk4.011451.01   Tripeptidyl-peptidase II

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens tripeptidyl peptidase II Compounds References
Rattus norvegicus Tripeptidyl aminopeptidase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bacillus lentus Subtilisin 269 aa 26.4% 246 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.053 0.341 0.4178
0.2354 0.8266 1
0.0268 0.9932 0.9932
0.0306 0.4216 0.4302
0.0828 0.2831 0.77
0.0264 0.2703 0.9657
0.1367 0.797 1
0.1618 0.5247 0.6852
0.0912 0.6588 1
0.0817 0.7109 1
0.0824 0.3284 0.3282
0.0265 0.3247 0.7236
0.232 0.6112 1
0.1396 0.3459 0.5601
0.0267 0.2798 0.4418
0.2354 0.8388 0.9275
0.0261 0.2805 0.4103
0.0264 0.6379 0.5765
0.2314 0.9351 1
0.0831 0.3348 0.3348
0.234 0.27 1
0.234 0.27 1
0.0902 0.857 1
0.0264 0.4326 0.4348
0.2349 0.3641 0.619
0.0541 0.2577 0.7345
0.2354 0.8388 0.9275
0.053 0.3872 0.3872
0.1339 0.9683 1
0.0264 0.3795 0.3795
0.0272 0.2578 0.3734
0.1074 0.9346 0.9844
0.0867 0.2637 0.2635
0.1074 0.4178 0.9765
0.0264 0.2658 0.7485
0.0816 0.5338 0.533
0.0319 0.3919 1
0.234 0.27 1
0.1238 0.9853 1
0.0824 0.4307 0.5132
0.0801 0.2577 0.6994
0.079 0.874 1
0.0263 0.318 1
0.0529 0.4627 0.4627
0.0264 0.2978 0.2978
0.0526 0.6514 1
0.1369 0.9521 0.9779
0.1367 0.9706 1
0.232 0.6112 1
0.0319 0.3919 1
0.0817 0.2867 0.6729
0.0528 0.7955 1
0.1732 0.9941 1
0.0865 0.6112 1
0.1394 0.5544 1
0.1238 0.9853 1
0.1639 0.5293 0.5293
0.234 0.27 1
0.234 0.27 1
0.1362 0.6838 0.8838
0.234 0.27 1
0.1082 0.4224 0.4211
0.1366 0.3234 0.3234
0.0561 0.3693 0.3686
0.054 0.2878 0.2877
0.0524 0.451 0.6852
0.0846 0.2572 0.2569
0.0559 0.299 0.299
0.0539 0.2601 0.7374
0.0263 0.3922 0.3922
0.0559 0.3003 0.3003
0.234 0.27 1
0.0863 0.8085 1
0.0856 0.5768 1
0.1109 0.5947 0.5947
0.1399 0.4086 0.4086
0.234 0.27 1
0.0805 0.5958 0.5958
0.0293 0.3325 0.5362
0.202 0.7338 1
0.0286 0.5981 1
0.0267 0.2798 0.4418
0.0281 0.6508 0.7315
0.1732 0.9941 1
0.0866 0.606 1
0.0798 0.4812 1
0.0559 0.299 0.299
0.2354 0.8266 1
0.0276 0.2809 0.2809
0.0267 0.2554 0.5815
0.0539 0.6255 1
0.0274 0.2769 0.5508
0.0905 0.4246 1
0.0261 0.3103 0.9133
0.1066 0.4027 1
0.1394 0.5544 1
0.234 0.27 1
0.0612 0.3474 1
0.1121 0.3728 0.3726
0.234 0.27 1
0.0536 0.6669 1
0.0529 0.4716 0.4716
0.0824 0.3633 0.3625
0.0272 0.2818 0.5807
0.0826 0.3463 0.3463
0.2283 0.7151 1
0.0833 0.8276 1
0.1108 0.4702 1
0.0845 0.2691 1
0.0301 0.4349 0.4445
0.2297 0.8067 1
0.0267 0.3032 0.8914
0.0264 0.3126 0.5693
0.0263 0.4486 0.446
0.1348 0.9315 1
0.0283 0.3917 0.3917
0.1396 0.4814 0.896
0.0538 0.5561 0.8533
0.2354 0.8266 1
0.2009 0.9138 0.9138
0.0524 0.4369 0.4369
0.234 0.27 1
0.0849 0.7997 1
0.0538 0.4082 0.408
0.0827 0.7159 0.7159
0.1396 0.3459 0.5601
0.1066 0.4027 1
0.0561 0.3507 0.7537
0.234 0.27 1
0.1948 0.3961 1
0.029 0.3217 0.4801
0.0219 0.7427 0.7427
0.2297 0.8067 1
0.2297 0.8067 1
0.0268 0.9733 0.9733
0.0837 0.7374 1
0.234 0.27 1
0.0265 0.3261 0.3215
0.0267 0.476 1
0.234 0.27 1
0.0817 0.5013 1
0.1074 0.4178 0.9765
0.0936 0.3387 1
0.0275 0.3692 0.3692
0.1059 0.2854 0.2854
0.055 0.3006 0.3002
0.1094 0.364 0.364
0.027 0.6664 0.6664
0.1238 0.9853 1
0.0327 0.7785 1
0.0828 0.5261 1
0.0263 0.4486 0.446
0.0814 0.2632 1
0.202 0.7338 1
0.0524 0.4987 0.4986
0.1396 0.3459 0.5601
0.0283 0.4321 0.387
0.2354 0.8266 1
0.0265 0.3482 0.3482
0.1074 0.4178 0.9765
0.0261 0.2944 1
0.0539 0.625 1
0.088 0.8782 1
0.0529 0.3594 1
0.0842 0.7685 1
0.0612 0.3474 1
0.0795 0.8067 1
0.1394 0.6197 1
0.0866 0.6408 1
0.0266 0.4059 0.3274
0.0886 0.5868 0.5868
0.1101 0.7836 1
0.2354 0.8266 1
0.0261 0.2597 0.3885
0.0265 0.3448 0.433
0.0538 0.6704 1
0.0539 0.626 1
0.0261 0.2805 0.4103
0.0798 0.4812 1
0.234 0.27 1
0.0829 0.8923 1
0.029 0.4615 0.3984
0.0306 0.4289 0.4342
0.1663 0.3715 1
0.0554 0.3497 0.8432
0.0306 0.4216 0.4302
0.0263 0.6597 0.7295
0.0539 0.6255 1
0.0268 0.2667 0.5503
0.0855 0.7918 1
0.0904 0.6594 1
0.0547 0.7216 1
0.0537 0.7578 0.7578
0.1934 0.6448 1
0.0837 0.7374 1
0.1094 0.364 0.364
0.0831 0.7577 1
0.0863 0.6297 1
0.1348 0.9315 1
0.0867 0.2637 0.2635
0.0288 0.3888 0.3888
0.0949 0.3492 1
0.0274 0.6491 0.6491
0.1903 0.8422 1
0.0828 0.842 1
0.2354 0.8266 1
0.027 0.4132 0.4132
0.0235 0.2957 0.2957
0.0863 0.2504 1
0.1074 0.4178 0.9765
0.0267 0.335 0.5237
0.0547 0.7651 0.7643
0.0827 0.7159 0.7159
0.0863 0.6297 1
0.0544 0.6922 0.6921
0.0543 0.2645 0.2645
0.0817 0.5013 1
0.2349 0.3641 0.619
0.0864 0.6052 1
0.0832 0.8739 0.8739
0.0828 0.842 1
0.0264 0.2703 0.9657
0.1623 0.4758 0.9636
0.0261 0.2597 0.3885
0.1396 0.3459 0.5601
0.0528 0.5945 1
0.0896 0.8573 1
0.0265 0.3448 0.433
0.0261 0.475 0.475
0.093 0.3399 1
0.1961 0.296 1
0.0275 0.371 0.371
0.0268 0.3231 0.4277
0.0865 0.6112 1
0.1399 0.4086 0.4086
0.0796 0.4609 0.4863
0.234 0.27 1
0.2283 0.7151 1
0.1622 0.4129 0.4129
0.0266 0.3931 1
0.029 0.3217 0.4801
0.2045 0.9066 0.9065
0.0297 0.3967 0.3967
0.0277 0.3714 0.3714
0.0267 0.3245 0.3344
0.0303 0.4068 0.4472
0.0531 0.2606 1
0.1078 0.8731 0.8731
0.0528 0.321 0.7065
0.0272 0.2609 0.6865
0.0261 0.2651 1
0.0905 0.4247 1
0.0829 0.9953 1
0.0905 0.4246 1
0.1366 0.5943 1
0.0607 0.3748 0.3748
0.1399 0.9833 1
0.197 0.5213 0.5211
0.0832 0.8739 0.8739
0.0524 0.4987 0.4986
0.0263 0.318 1
0.0544 0.6922 0.6921
0.0882 0.5348 1
0.0261 0.255 0.669
0.0796 0.4609 0.4863
0.0536 0.3959 0.3954
0.0827 0.7159 0.7159
0.1238 0.9853 1
0.0846 0.2572 0.2569
0.087 0.8559 1
0.1074 0.4178 0.9765
0.1122 0.897 0.897
0.0277 0.585 0.8166
0.234 0.27 1
0.234 0.27 1
0.0833 0.8481 1
0.1948 0.3961 1
0.0271 0.2873 0.2979
0.1394 0.5544 1
0.0233 0.3687 0.5304
0.2349 0.3641 0.619
0.0265 0.3051 0.8821
0.0266 0.4059 0.3274
0.088 0.7964 1
0.0273 0.703 0.7592
0.0827 0.3757 0.5657
0.1238 0.9853 1
0.2354 0.8266 1
0.1348 0.9315 1
0.1142 0.2914 0.2903
0.2297 0.8067 1
0.2354 0.8266 1
0.0905 0.4246 1
0.0266 0.3931 1
0.0264 0.3709 0.8217
0.1623 0.4723 0.4723
0.0319 0.3919 1
0.1096 0.9877 1
0.0264 0.4326 0.4348
0.2354 0.8266 1
0.079 0.4727 0.838
0.0266 0.3931 1
0.0531 0.4354 0.4344
0.0555 0.3589 0.3576
0.0264 0.3645 0.3645
0.2314 0.9351 1
0.0849 0.7964 1
0.234 0.27 1
0.1961 0.296 1
0.0543 0.8326 0.8326
0.0264 0.2577 0.401
0.0824 0.3633 0.3625
0.1078 0.9803 0.9803
0.0301 0.4349 0.4445
0.0297 0.4081 0.5236
0.0273 0.7625 0.9836
0.0265 0.328 1
0.0289 0.2893 0.5228
0.2349 0.3814 1
0.2297 0.8067 1
0.0878 0.408 1
0.0865 0.6112 1
0.0913 0.8691 1
0.0266 0.3342 0.3342
0.0842 0.2613 0.2613
0.2354 0.8266 1
0.0538 0.5561 0.8533
0.0869 0.8552 1
0.0828 0.2831 0.77
0.0247 0.8919 0.8839
0.028 0.3833 0.9384
0.0828 0.842 1
0.0267 0.3236 1
0.0801 0.6945 0.6945
0.1639 0.6131 1
0.0921 0.3365 0.7604
0.0294 0.3503 0.4228
0.0545 0.4205 0.9
0.0525 0.4912 1
0.1961 0.296 1
0.0538 0.6704 1
0.0829 0.9953 1
0.1399 0.4086 0.4086
0.1238 0.9853 1
0.054 0.2878 0.2877
0.0267 0.476 1
0.1238 0.9853 1
0.0265 0.3448 0.433
0.0273 0.8081 1
0.0524 0.4987 0.4986
0.0265 0.3154 1
0.234 0.27 1
0.1238 0.9853 1
0.1948 0.3961 1
0.2009 0.9138 0.9138
0.027 0.3638 0.3638
0.2009 0.9138 0.9138
0.0793 0.3848 0.3858
0.234 0.27 1
0.0874 0.7589 1
0.0264 0.3232 0.344
0.0272 0.2609 0.6865
0.1366 0.5943 1
0.0283 0.3917 0.3917
0.0285 0.2834 0.7209
0.202 0.7338 1
0.0921 0.3365 0.7604
0.2297 0.8067 1
0.0548 0.6692 1
0.1663 0.3715 1
0.0281 0.3677 0.3677
0.0524 0.2785 0.2785
0.0819 0.983 1
0.0271 0.2873 0.2979
0.0829 0.4443 0.4437
0.0264 0.3126 0.5693
0.0536 0.6669 1
0.232 0.6112 1
0.1074 0.4178 0.9765
0.234 0.27 1
0.1961 0.296 1
0.1364 0.9683 1
0.2354 0.8266 1
0.1903 0.8422 1
0.0821 0.2607 1
0.1361 0.9026 0.9025
0.1396 0.3459 0.5601

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_25090 (Brugia malayi), Subtilase family protein
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