Detailed view for Bm1_40280

Basic information

TDR Targets ID: 243519
Brugia malayi, AIDA-1b
Source Database / ID:  GenBank

pI: 7.0754 | Length (AA): 1324 | MW (Da): 146339 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00536   SAM domain (Sterile alpha motif)
PF00640   Phosphotyrosine interaction domain (PTB/PID)
PF12796   Ankyrin repeats (3 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 14 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 303 5g4x (A) 55 339 26.00 0.0000023 1 0.372789 0.76
61 183 4gmr (A) 35 155 47.00 0 1 0.6669 -0.65
61 156 5eyp (F) 45 138 41.00 0.000000000074 1 0.667508 -1.16
63 149 2fo1 (E) 1207 1292 33.00 0.0049 1 0.51671 -0.42
77 289 4g8k (A) 39 251 25.00 0.00084 1 0.389876 0.3
219 300 2xen (A) 21 100 36.00 0.000042 1 0.576934 -1.16
223 289 1ycs (B) 338 405 36.00 0.046 0.99 0.528604 -0.4
241 279 5hs0 (A) 1 39 46.00 0 1 0.657256 -0.95
1060 1130 3h8m (A) 920 988 32.00 0.00093 1 0.528625 -1.93
1068 1124 2eam (A) 15 71 28.00 0.55 0.85 0.474051 -0.77
1147 1310 3f0w (A) 48 197 30.00 0 1 0.419667 -0.63
1166 1319 1wj1 (A) 3 154 26.00 0 1 0.347314 -0.29
1182 1310 2m38 (A) 12 146 43.00 0 1 0.552432 -0.83
1191 1318 1p3r (A) 50 179 24.00 0.000000013 0.95 0.336677 -0.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132174)

Species Accession Gene Product
Brugia malayi Bm1_40280   AIDA-1b
Caenorhabditis elegans CELE_C11E4.6   Protein C11E4.6
Drosophila melanogaster Dmel_CG11168   CG11168 gene product from transcript CG11168-RC
Drosophila melanogaster Dmel_CG4393   CG4393 gene product from transcript CG4393-RD
Homo sapiens ENSG00000185046   ankyrin repeat and sterile alpha motif domain containing 1B
Homo sapiens ENSG00000064999   ankyrin repeat and sterile alpha motif domain containing 1A
Loa Loa (eye worm) LOAG_01860   AIDA-1b
Mus musculus ENSMUSG00000058589   ankyrin repeat and sterile alpha motif domain containing 1B
Mus musculus ENSMUSG00000024219   ankyrin repeat and SAM domain containing 1
Onchocerca volvulus OVOC5201  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_40280 (Brugia malayi), AIDA-1b
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