Detailed view for Bm1_36795

Basic information

TDR Targets ID: 244732
Brugia malayi, Ferm domain
Source Database / ID:  GenBank

pI: 6.3839 | Length (AA): 1360 | MW (Da): 152568 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00373   FERM central domain
PF00595   PDZ domain (Also known as DHR or GLGF)
PF09379   FERM N-terminal domain
PF09380   FERM C-terminal PH-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005856   cytoskeleton  
GO:0005515   protein binding  
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 132 2bva (A) 399 568 20.00 0.97 1 0.0489529 -0.45
7 137 3p1a (A) 193 360 18.00 0.49 0.99 0.159424 -0.95
8 105 4ow8 (A) 103 216 21.00 0.67 1 0.239159 -1.18
313 851 3pvl (A) 1025 1634 12.00 0 1 0.358124 0.88
882 963 2awx (A) 317 402 39.00 0.00001 0.96 0.582694 -1.16
887 942 1wi4 (A) 10 76 46.00 0.18 0.94 0.380576 0.15
1134 1224 3i4w (A) 305 397 31.00 0 1 0.594712 -1.71
1138 1223 2vrf (A) 0 200 23.00 0 1 0.477035 -1.51
1138 1316 3gsl (A) 61 246 30.00 0 1 0.441418 0.08
1154 1222 3bpu (A) 654 724 42.00 0.041 1 0.545135 -1.04
1229 1315 2css (A) 15 114 39.00 0.049 1 0.446371 -0.42
1232 1316 2qg1 (A) 1722 1806 36.00 0 1 0.6343 -1.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_135820)

Species Accession Gene Product
Brugia malayi Bm1_36795   Ferm domain
Caenorhabditis elegans CELE_Y38C1AB.4   Protein FRM-5.2
Caenorhabditis elegans CELE_Y38C1AB.8   Protein FRM-5.1, isoform B
Homo sapiens ENSG00000163629   protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Loa Loa (eye worm) LOAG_01159   hypothetical protein
Mus musculus ENSMUSG00000034573   protein tyrosine phosphatase, non-receptor type 13
Onchocerca volvulus OVOC4542  
Schmidtea mediterranea mk4.010153.00  

Essentiality

Bm1_36795 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y38C1AB.8 Caenorhabditis elegans embryonic arrest wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0085 0.5264 0.5205
0.0245 0.4241 0.4241

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_36795 (Brugia malayi), Ferm domain
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