pI: 5.6349 |
Length (AA): 685 |
MW (Da): 77197 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 685 | 1y79 (1) | 1 | 678 | 23.00 | 0 | 1 | 1.39 | -1.31 |
26 | 685 | 1s4b (P) | 29 | 677 | 33.00 | 0 | 1 | 1.5 | -1.45 |
1 | 685 | 4ka7 (A) | 95 | 784 | 22.00 | 0 | 1 | 1.3032 | -0.56 |
20 | 685 | 2o36 (A) | 26 | 677 | 33.00 | 0 | 1 | 1.42546 | -0.66 |
20 | 685 | 2o3e (A) | 27 | 678 | 31.00 | 0 | 1 | 1.40646 | -0.67 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | amastigotes. | Fernandes MC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_127067)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G10540 | zincin-like metalloproteases family protein |
Arabidopsis thaliana | AT5G65620 | organellar oligopeptidase A |
Arabidopsis thaliana | AT1G67690 | zincin-like metalloproteases-like protein |
Brugia malayi | Bm1_40845 | Peptidase family M3 containing protein |
Candida albicans | CaO19.8064 | saccharolysin (oligopeptidase) |
Candida albicans | CaO19.434 | saccharolysin (oligopeptidase) |
Caenorhabditis elegans | CELE_ZK550.3 | Protein ZK550.3 |
Dictyostelium discoideum | DDB_G0292362 | peptidase M3A and M3B domain-containing protein |
Drosophila melanogaster | Dmel_CG11771 | CG11771 gene product from transcript CG11771-RA |
Drosophila melanogaster | Dmel_CG3790 | CG3790 gene product from transcript CG3790-RA |
Escherichia coli | b1538 | dipeptidyl carboxypeptidase II |
Escherichia coli | b3498 | oligopeptidase A |
Entamoeba histolytica | EHI_001080 | hypothetical protein |
Entamoeba histolytica | EHI_185560 | oligopeptidase A, putative |
Homo sapiens | ENSG00000123213 | neurolysin (metallopeptidase M3 family) |
Homo sapiens | 7064 | thimet oligopeptidase 1 |
Leishmania braziliensis | LbrM.26.1590 | thimet oligopeptidase, putative,metallo-peptidase, Clan MA(E), Family M3 |
Leishmania braziliensis | LbrM.27.2760 | peptidyl dipeptidase, putative,metallo-peptidase, Clan MA(E), Family M3 |
Leishmania braziliensis | LbrM.27.1640 | peptidyl dipeptidase, putative,metallo-peptidase, Clan MA(E), Family M3 |
Leishmania braziliensis | LbrM.27.2780 | metallo-peptidase, Clan MA(E), Family M3 |
Leishmania braziliensis | LbrM.27.1650 | peptidyl dipeptidase, putative,metallo-peptidase, Clan MA(E), Family M3 |
Leishmania donovani | LdBPK_020710.1 | peptidyl-dipeptidase, putative |
Leishmania donovani | LdBPK_261550.1 | thimet oligopeptidase, putative |
Leishmania donovani | LdBPK_010850.1 | peptidyl dipeptidase, putative |
Leishmania infantum | LinJ.26.1550 | thimet oligopeptidase, putative,metallo-peptidase, Clan MA(E), Family M3 |
Leishmania infantum | LinJ.02.0710 | dipeptylcarboxypeptidase |
Leishmania major | LmjF.02.0740 | dipeptylcarboxypeptidase, putative;with=GeneDB:LinJ02_V3.0710 |
Leishmania major | LmjF.27.2660 | peptidyl dipeptidase, putative,metallo-peptidase, Clan MA(E), Family M3 |
Leishmania major | LmjF.01.0830 | peptidyl dipeptidase, putative,metallo-peptidase, Clan MA(E), Family M3 |
Leishmania major | LmjF.26.1570 | thimet oligopeptidase, putative,metallo-peptidase, Clan MA(E), Family M3 |
Leishmania mexicana | LmxM.26.1570 | thimet oligopeptidase, putative,metallo-peptidase, Clan MA(E), Family M3 |
Leishmania mexicana | LmxM.02.0740 | peptidyl dipeptidase, putative,metallo-peptidase, Clan MA(E), Family M3 |
Loa Loa (eye worm) | LOAG_03334 | peptidase family M3 containing protein |
Mus musculus | ENSMUSG00000021710 | neurolysin (metallopeptidase M3 family) |
Mus musculus | ensembl-mmu:ENSMUSG00000004929 | thimet oligopeptidase 1 |
Oryza sativa | 4331244 | Os02g0830100 |
Oryza sativa | 4325012 | Os01g0902200 |
Onchocerca volvulus | OVOC5353 |
|
Saccharomyces cerevisiae | YCL057W | Prd1p |
Schistosoma japonicum | Sjp_0015820 | ko:K01392 thimet oligopeptidase [EC3.4.24.15], putative |
Schistosoma mansoni | Smp_029500 | thimet oligopeptidase (M03 family) |
Schistosoma mansoni | Smp_029470 | thimet oligopeptidase (M03 family) |
Schmidtea mediterranea | mk4.035936.00 | |
Schmidtea mediterranea | mk4.005475.00 | |
Trypanosoma brucei gambiense | Tbg972.7.70 | thimet oligopeptidase A, putative,metallo- peptidase, Clan MA(E) Family M3, putative |
Trypanosoma brucei | Tb927.7.190 | thimet oligopeptidase, putative |
Trypanosoma congolense | TcIL3000_7_10 | thimet oligopeptidase, putative |
Trypanosoma cruzi | TcCLB.511237.10 | thimet oligopeptidase, putative |
Trypanosoma cruzi | TcCLB.506411.10 | thimet oligopeptidase, putative |
Trichomonas vaginalis | TVAG_477180 | Clan MA, family M3, oligopeptidase A-like metallopeptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.190 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.190 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.190 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.190 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1538 | Escherichia coli | non-essential | goodall |
b3498 | Escherichia coli | non-essential | goodall |
CELE_ZK550.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | dipeptylcarboxypeptidase, putative;with=GeneDB:LinJ02_V3.0710 | Compounds | References |