Detailed view for LmjF.04.0060

Basic information

TDR Targets ID: 24604
Leishmania major, DNA topoisomerase type IB small subunit

Source Database / ID:  TriTrypDB  GeneDB

pI: 6.9688 | Length (AA): 262 | MW (Da): 28100 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14370   C-terminal topoisomerase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005694   chromosome  
GO:0003917   DNA topoisomerase type I activity  
GO:0003677   DNA binding  
GO:0006268   DNA unwinding during replication  
GO:0006265   DNA topological change  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
211 262 2b9s (B) 211 262 99.99 0 1 1.35 -1.68
88 132 2b9s (A) 405 456 16.00 0.86 0.01 0.294156 -1
211 262 2b9s (B) 211 262 99.99 0 1 1.31617 -0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 2B9S:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_145769)

Species Accession Gene Product
Leishmania braziliensis LbrM.04.0110   DNA topoisomerase type IB small subunit
Leishmania donovani LdBPK_040070.1   DNA topoisomerase type IB small subunit
Leishmania infantum LinJ.04.0070   DNA topoisomerase type IB small subunit
Leishmania major LmjF.04.0060   DNA topoisomerase type IB small subunit
Leishmania mexicana LmxM.04.0060   DNA topoisomerase type IB small subunit
Trypanosoma brucei gambiense Tbg972.9.3670   DNA topoisomerase type IB small subunit, putative
Trypanosoma brucei Tb927.9.6940   DNA topoisomerase type IB small subunit
Trypanosoma congolense TcIL3000_0_29220   DNA topoisomerase type IB small subunit, putative
Trypanosoma cruzi TcCLB.506625.110   DNA topoisomerase type IB small subunit, putative

Essentiality

LmjF.04.0060 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.5070 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.5070 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.5070 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.5070 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
ChEMBL23 References
ChEMBL23 References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma brucei DNA topoisomerase type IB small subunit Compounds References
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.5739 0.3494 0.4698
0.5461 0.3525 0.474
0.2221 0.6893 0.9493
0.5032 0.3625 0.4878
0.3655 0.3075 0.4739
0.6193 0.3376 0.4536
0.6978 0.3265 0.4384
0.5355 0.3549 0.4774
0.5264 0.3601 0.4845
0.4299 0.3826 0.5155
0.4321 0.3816 0.5142
0.4963 0.3534 0.4755
0.6978 0.3265 0.4384
0.5332 0.3562 0.4791
0.6443 0.3371 0.4529
0.2502 0.5727 0.7821
0.6463 0.3358 0.4511
0.7124 0.3247 0.4358
0.4571 0.3748 0.5047
0.394 0.4049 0.5466
0.4961 0.36 0.4845
0.5844 0.3464 0.4656
0.5323 0.347 0.4665
0.1892 0.9893 1
0.3655 0.3075 0.4739
0.2996 0.4808 0.6525
0.3667 0.4195 0.5667
0.4093 0.3929 0.5299
0.248 0.5979 0.818
0.5114 0.3627 0.488
0.6334 0.3331 0.4474
0.6265 0.3321 0.446
0.7288 0.3293 0.4421
0.4753 0.3669 0.4938
0.4945 0.363 0.4886
0.6905 0.3266 0.4386
0.2377 0.6285 0.8618
0.5844 0.3464 0.4656
0.4763 0.2578 0.503
0.6962 0.3265 0.4383
0.6579 0.33 0.4431
0.6856 0.3276 0.4398
0.5994 0.3431 0.4611
0.4563 0.338 0.4542
0.4641 0.3796 0.5115
0.6905 0.3266 0.4386
0.4815 0.3713 0.5
0.3655 0.3075 0.4739
0.6652 0.3288 0.4415
0.3561 0.4348 0.588
0.7421 0.3234 0.434
0.6463 0.3378 0.4538
0.493 0.3041 0.3041
0.3608 0.4242 0.5733
0.5943 0.3399 0.4567
0.5578 0.3491 0.4694
0.6992 0.3295 0.4426
0.7146 0.3303 0.4435
0.3793 0.4034 0.5444
0.6152 0.3349 0.4498
0.5244 0.3479 0.4678
0.394 0.4049 0.5466
0.4785 0.3639 0.4897
0.666 0.3287 0.4414
0.5176 0.3608 0.4854
0.4613 0.3787 0.5103
0.4763 0.2578 0.503
0.5875 0.3451 0.4639
0.7253 0.3251 0.4364
0.3655 0.3075 0.4739
0.4559 0.3811 0.5136
0.493 0.3041 0.3041
0.4158 0.3922 0.5289
0.2349 0.6495 0.8918
0.394 0.4049 0.5466
0.4337 0.3876 0.5225
0.5011 0.3561 0.479
0.1934 0.2504 0.3346
0.6227 0.339 0.4554
0.439 0.3867 0.5213
0.2579 0.5705 0.779
0.3744 0.4171 0.5634
0.5771 0.3409 0.4581
0.5348 0.3556 0.4784
0.515 0.3544 0.4767
0.394 0.4049 0.5466
0.3579 0.4289 0.5798
0.3655 0.3075 0.4739
0.513 0.3515 0.4727
0.658 0.3282 0.4407
0.394 0.4049 0.5466
0.4217 0.39 0.5258
0.5076 0.3548 0.4772
0.2996 0.4808 0.6525
0.2051 0.3779 0.3778
0.6905 0.3266 0.4386
0.3982 0.4022 0.5427
0.6389 0.3387 0.455
0.3119 0.4719 0.6401
0.7284 0.3247 0.4359
0.5033 0.3571 0.4805
0.3358 0.4457 0.6033
0.3466 0.4376 0.592
0.275 0.5243 0.7134
0.4026 0.3896 0.5253
0.2529 0.5821 0.7957
0.6905 0.3266 0.4386
0.7068 0.3254 0.4369
0.6391 0.3279 0.4402
0.3469 0.4362 0.59
0.0424 0.2597 1
0.1977 0.8616 1
0.6924 0.3302 0.4434
0.6229 0.3434 0.4616
0.6978 0.3265 0.4384
0.3857 0.4122 0.5567
0.6055 0.3441 0.4625
0.4776 0.3681 0.4956
0.3529 0.433 0.5857
0.6831 0.3273 0.4395
0.4939 0.3595 0.4837
0.732 0.3293 0.4422
0.3156 0.466 0.6313
0.4731 0.3671 0.4943
0.3264 0.4544 0.6154
0.6708 0.3307 0.4441
0.1939 0.6297 1
0.5496 0.3498 0.4704
0.6992 0.3295 0.4426
0.368 0.4142 0.5592
0.5368 0.2591 0.4749
0.2539 0.5822 0.7956
0.3655 0.3075 0.4739
0.2133 0.2748 1
0.3608 0.4242 0.5733
0.4678 0.3718 0.5007
0.4458 0.3811 0.5135
0.3709 0.4173 0.5638
0.3908 0.41 0.5535
0.5348 0.3497 0.4701
0.3145 0.4734 0.6421
0.5925 0.3469 0.4664
0.4187 0.3924 0.5292
0.3594 0.4303 0.5816
0.3203 0.4613 0.6248
0.5484 0.3567 0.4799
0.5108 0.3586 0.4825
0.6386 0.3366 0.4522
0.4563 0.338 0.4542
0.4497 0.3725 0.5017
0.3934 0.4031 0.544
0.3655 0.3075 0.4739
0.2908 0.4987 0.6775
0.6992 0.3295 0.4426
0.4754 0.3692 0.497
0.715 0.3298 0.4428
0.5321 0.3455 0.4644
0.3655 0.3075 0.4739
0.7005 0.3314 0.4451
0.394 0.4049 0.5466
0.274 0.5194 0.7067
0.3255 0.2547 0.6168
0.3274 0.4546 0.6159
0.732 0.3293 0.4422
0.4944 0.3683 0.4958
0.7261 0.3224 0.4327
0.6697 0.3286 0.4412
0.5627 0.3414 0.4588
0.4312 0.2507 0.3349
0.4776 0.3681 0.4956
0.7124 0.3301 0.4433
0.4617 0.375 0.5052
0.3655 0.3075 0.4739
0.47556 0.325693 0.437413
0.2186 0.721 0.9949
0.4358 0.3898 0.5255
0.6265 0.332 0.4459
0.3184 0.4654 0.6309
0.4021 0.3989 0.5381
0.224 0.6932 0.9548
0.5759 0.3424 0.4602
0.7157 0.3283 0.4407
0.5011 0.3616 0.4867
0.598 0.3429 0.4608
0.5496 0.3498 0.4704
0.2031 0.8165 1
0.3655 0.3075 0.4739
0.6978 0.3265 0.4384
0.4598 0.3752 0.5054
0.4082 0.3908 0.527
0.5323 0.347 0.4665
0.4252 0.3941 0.5314
0.5979 0.3259 0.4333
0.3608 0.4242 0.5733
0.6254 0.3396 0.4563
0.2186 0.721 0.9949
0.359 0.4283 0.579
0.3255 0.2547 0.6168
0.4813 0.37 0.4981
0.2133 0.2748 1
0.7325 0.3236 0.4344
0.3388 0.4344 0.5878
0.6094 0.3416 0.4591
0.2133 0.2748 1
0.3852 0.4005 0.5403
0.381 0.4147 0.5602
0.2267 0.6648 0.9139
0.3996 0.2997 0.5378
0.5496 0.3498 0.4704
0.6643 0.3337 0.4482
0.6992 0.3295 0.4426
0.4678 0.3718 0.5007
0.5979 0.3259 0.4333
0.6229 0.3434 0.4616
0.4834 0.3434 0.4999
0.5913 0.3478 0.4676
0.2149 0.7427 1
0.533932 0.314947 0.422416
0.515 0.3544 0.4767
0.2863 0.5079 0.6903
0.6308 0.334 0.4486
0.3739 0.4074 0.5499
0.3327 0.4478 0.6059
0.493 0.3041 0.3041
0.6193 0.3376 0.4536
0.6905 0.3266 0.4386
0.6389 0.3387 0.455
0.3754 0.4128 0.5573
0.6038 0.3395 0.4562
0.4559 0.3811 0.5136
0.5453 0.3523 0.4737
0.3145 0.4734 0.6421
0.6375 0.3368 0.4524
0.3255 0.4547 0.6162
0.6024 0.3425 0.4603
0.4477 0.3793 0.5111
0.2675 0.5455 0.7436
0.5721 0.3425 0.4603
0.6816 0.3318 0.4457
0.4963 0.3534 0.4755
0.3655 0.3075 0.4739
0.3489 0.4293 0.5804
0.394 0.4049 0.5466
0.5386 0.3444 0.4629
0.4821 0.369 0.4967
0.4003 0.4076 0.5503
0.4963 0.3534 0.4755
0.6623 0.3302 0.4434
0.2964 0.4924 0.6687
0.2794 0.5152 0.7007
0.5448 0.3461 0.4652
0.6873 0.3314 0.4451
0.6193 0.3376 0.4536
0.199 0.8642 1
0.2285 0.669 0.9199
0.5435 0.3496 0.4702
0.2054 0.4257 1
0.5966 0.34 0.4568
0.4678 0.3718 0.5007
0.5024 0.3649 0.4911
0.6444 0.3336 0.448
0.4678 0.3718 0.5007
0.6992 0.3295 0.4426
0.3655 0.3075 0.4739
0.394 0.4049 0.5466
0.5512 0.3544 0.4767
0.0424 0.2597 1
0.5011 0.3601 0.4845
0.5559 0.3467 0.4661
0.6728 0.329 0.4417
0.198187 0.484744 0.659237
0.4026 0.3896 0.5253
0.3061 0.3432 0.4614
0.3655 0.3075 0.4739
0.4963 0.3534 0.4755
0.5075 0.3653 0.4917
0.493 0.3041 0.3041
0.6845 0.3319 0.4458
0.4555 0.3777 0.5089
0.5992 0.3405 0.4575
0.3255 0.4547 0.6162
0.5722 0.3484 0.4685
0.1943 0.2639 1
0.3788 0.415 0.5605
0.3255 0.2547 0.6168
0.5444 0.3462 0.4654
0.5368 0.2591 0.4749
0.6802 0.3331 0.4474
0.394 0.4049 0.5466
0.4002 0.4011 0.5411
0.3791 0.324 0.4349
0.2267 0.6648 0.9139
0.4567 0.3657 0.4922
0.6145 0.3412 0.4585
0.495 0.3591 0.4832
0.3366 0.2505 0.3346
0.2297 0.3545 0.9221
0.5465 0.3519 0.4732
0.40958 0.334034 0.44883
0.6597 0.335 0.4499
0.5736 0.3443 0.4628
0.3615 0.4257 0.5755
0.2133 0.2748 1
0.5721 0.3425 0.4603
0.4776 0.3681 0.4956
0.1925 0.9228 1
0.4398 0.3822 0.515
0.3145 0.4734 0.6421
0.337 0.4458 0.6035
0.394 0.4049 0.5466
0.6443 0.3317 0.4455
0.3752 0.4045 0.5459
0.7146 0.3303 0.4435
0.2302 0.6712 0.9231
0.6642 0.3335 0.448
0.385 0.4106 0.5545
0.394 0.4049 0.5466
0.4817 0.3676 0.4949
0.6086 0.3391 0.4556
0.1939 0.6297 1
0.484 0.3691 0.4969
0.3255 0.4547 0.6162
0.4678 0.3718 0.5007
0.3357 0.4458 0.6034
0.0377 0.4091 1
0.737 0.3277 0.4399
0.7022 0.3312 0.4447
0.493 0.3041 0.3041
0.4814 0.3714 0.5002
0.2524 0.5548 0.7933
0.394 0.4049 0.5466
0.5466 0.349 0.4692
0.3529 0.433 0.5857
0.4084 0.3858 0.5201
0.7261 0.3224 0.4327
0.5685 0.3483 0.4683
0.493 0.3043 0.3042
0.2341 0.6514 0.8946
0.4993 0.3554 0.478
0.2718 0.5313 0.7232
0.7022 0.3307 0.444
0.5496 0.3498 0.4704
0.7195 0.3286 0.4413
0.4963 0.3534 0.4755
0.6228 0.3436 0.4618
0.3655 0.3075 0.4739
0.5793 0.341 0.4581
0.2456 0.5932 0.8111
0.4893 0.3631 0.4886
0.3655 0.3075 0.4739
0.6992 0.3295 0.4426
0.394 0.4049 0.5466
0.3655 0.3075 0.4739
0.5781 0.3488 0.469
0.4668 0.3733 0.5029
0.5281 0.3583 0.482
0.3667 0.4195 0.5667
0.6717 0.3319 0.4457
0.4678 0.3718 0.5007
0.7319 0.3256 0.4371
0.5269 0.3483 0.4684
0.5364 0.3544 0.4767
0.418 0.3898 0.5256
0.526 0.3557 0.4784
0.6651 0.3336 0.448
0.6857 0.3298 0.4429
0.3358 0.4457 0.6033
0.3225 0.4603 0.6238
0.5348 0.353 0.4747
0.2051 0.3779 0.3778
0.3765 0.4155 0.5611
0.5669 0.3396 0.4562
0.2524 0.5548 0.7933
0.4573 0.3773 0.5084
0.394 0.4049 0.5466
0.5487 0.352 0.4733
0.5776 0.3403 0.4572
0.5509 0.3527 0.4743
0.493 0.3041 0.3041
0.6843 0.333 0.4471
0.5011 0.3616 0.4867
0.5973 0.3363 0.4519
0.2297 0.3545 0.9221
0.5483 0.3527 0.4744
0.5461 0.3552 0.4777
0.5967 0.3389 0.4554
0.4467 0.3812 0.5136
0.2441 0.6151 0.8425
0.5496 0.3498 0.4704
0.3255 0.2547 0.6168
0.5901 0.3423 0.4601
0.6055 0.3441 0.4625
0.3655 0.3075 0.4739
0.3385 0.4377 0.592
0.2613 0.5554 0.7578
0.6265 0.332 0.4459
0.4818 0.3691 0.4968
0.6691 0.3349 0.4498
0.2719 0.5329 0.7257
0.486 0.3576 0.4811
0.5193 0.3574 0.4808
0.394 0.4049 0.5466
0.493 0.3041 0.3041
0.6071 0.341 0.4582
0.4559 0.3811 0.5136
0.3579 0.4289 0.5798
0.5825 0.3398 0.4566
0.3558 0.4291 0.5802
0.4945 0.363 0.4886
0.6261 0.3373 0.4532
0.6992 0.3295 0.4426
0.1992 0.8714 1
0.3608 0.4242 0.5733
0.4963 0.3534 0.4755
0.0669192 1 1
0.6288 0.3406 0.4576
0.3255 0.2547 0.6168
0.5578 0.3491 0.4694
0.335 0.4411 0.5967
0.4208 0.3851 0.5191
0.3655 0.3075 0.4739
0.2524 0.5548 0.7933
0.4477 0.3794 0.5112
0.2728 0.5355 0.7296
0.5172 0.3602 0.4847
0.421495 0.332781 0.447095
0.5599 0.3421 0.4597
0.3264 0.4544 0.6154
0.6152 0.3349 0.4498
0.3554 0.4286 0.5794
0.3466 0.4353 0.5887
0.6342 0.3339 0.4484
0.4223 0.3898 0.5255
0.515 0.3544 0.4767
0.2739 0.5358 0.7298
0.465 0.3701 0.4984
0.2129 0.7462 1
0.6086 0.3391 0.4556
0.4082 0.3972 0.5359
0.5781 0.3488 0.469
0.4821 0.369 0.4967
0.72 0.3296 0.4425
0.513 0.3515 0.4727
0.6875 0.3309 0.4445
0.6035 0.3371 0.4528
0.5167 0.361 0.4857
0.4572 0.3754 0.5057
0.5461 0.3525 0.474
0.2133 0.2747 1
0.4512 0.3833 0.5167
0.5869 0.3389 0.4553
0.2143 0.7526 1
0.3255 0.2547 0.6168
0.4559 0.3811 0.5136
0.3893 0.4023 0.5429
0.5461 0.3525 0.474
0.7137 0.3299 0.443
0.4164 0.3984 0.5373
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0.7261 0.3224 0.4327
0.394 0.4049 0.5466
0.633 0.3322 0.4462
0.5295 0.356 0.4789
0.6925 0.3302 0.4434
0.5675 0.3484 0.4684
0.5321 0.3565 0.4795
0.3255 0.4547 0.6162
0.0954 0.2507 0.3347
0.4963 0.3534 0.4755
0.4337 0.3876 0.5225
0.3021 0.4956 0.6732
0.3655 0.3075 0.4739
0.3255 0.4547 0.6162
0.5996 0.3436 0.4619
0.7063 0.331 0.4446
0.6971 0.3315 0.4451
0.3529 0.433 0.5857
0.2841 0.5024 0.6827
0.6868 0.3274 0.4395
0.4315 0.3758 0.5062
0.3388 0.4344 0.5878
0.72 0.3296 0.4425
0.4678 0.3718 0.5007
0.5671 0.3441 0.4625
0.394 0.4049 0.5466
0.456 0.3759 0.5063
0.3655 0.3075 0.4739
0.5979 0.3259 0.4333
0.3255 0.4547 0.6162
0.2051 0.3779 0.3778
0.5555 0.3463 0.4655
0.2932 0.489 0.6637
0.2905 0.4907 0.6662
0.3377 0.4311 0.5829
0.3976 0.407 0.5495
0.5653 0.3414 0.4588
0.6235 0.3373 0.4532
0.6578 0.33 0.4431
0.4025 0.3948 0.5325
0.4363 0.3863 0.5207
0.4668 0.3707 0.4991
0.394 0.4049 0.5466
0.3599 0.4227 0.5711
0.5448 0.3461 0.4652
0.4821 0.369 0.4967
0.4711 0.3722 0.5013
0.5572 0.3499 0.4704
0.4966 0.3562 0.4792
0.3011 0.4857 0.6588
0.4026 0.3896 0.5253
0.6651 0.3336 0.448
0.6791 0.3313 0.4449
0.4834 0.3434 0.4999
0.6157 0.3363 0.4517
0.5099 0.3559 0.4788
0.3221 0.452 0.612
0.3655 0.3075 0.4739
0.224 0.6932 0.9548
0.5348 0.3556 0.4784
0.5563 0.3538 0.4758
0.1939 0.6297 1
0.4572 0.3754 0.5057
0.5041 0.3629 0.4884
0.6086 0.3391 0.4556
0.4776 0.3681 0.4956
0.4665 0.3718 0.5006
0.493 0.3041 0.3041
0.2051 0.3779 0.3778
0.394 0.4049 0.5466
0.2752 0.5238 0.7128

Assayability

Assay information

  • ChEMBL
  • Inhibition of Leishmania donovani topoisomerase 1B-mediated relaxation of supercoiled pSK DNA after 30 mins by ethidium bromide staining based agarose gel electrophoresis
  • ChEMBL
  • Inhibition of Leishmania donovani topoisomerase 1B-mediated relaxation of supercoiled pSK DNA at 100 uM after 4 mins by ethidium bromide staining based agarose gel electrophoresis
  • ChEMBL
  • Inhibition of Leishmania donovani topoisomerase 1B-mediated relaxation of supercoiled pSK DNA at 100 uM preincubated for 15 mins by ethidium bromide staining based agarose gel electrophoresis

Reagent availability

  • Reagent:
  • Target Type Source Notes
    LmjF.04.0060 purified protein BRENDA A protein with this EC number or name or sequence has been purified from Leishmania donovani ( 1 )

Bibliographic References

29 literature references were collected for this gene.

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Gene identifier LmjF.04.0060 (Leishmania major), DNA topoisomerase type IB small subunit
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