Detailed view for LmjF.01.0335

Basic information

TDR Targets ID: 24644
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.5658 | Length (AA): 97 | MW (Da): 10739 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03650   Uncharacterised protein family (UPF0041)

Gene Ontology

Mouse over links to read term descriptions.
GO:0006850   mitochondrial pyruvate transport  
GO:0005743   mitochondrial inner membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_128371)

Species Accession Gene Product
Arabidopsis thaliana AT5G20090   hypothetical protein
Babesia bovis BBOV_II005770   brain protein 44-like protein, putative
Brugia malayi Bm1_46220   Hypothetical UPF0041 protein R07E5.13 in chromosome III
Candida albicans CaO19.252   member of uncharacterised protein family (UPF0041) similar to S. cerevisiae FMP37 (YGL080W) mitochondrial protein
Candida albicans CaO19.7884   member of uncharacterised protein family (UPF0041) similar to S. cerevisiae FMP37 (YGL080W) mitochondrial protein
Caenorhabditis elegans CELE_R07E5.13   Protein R07E5.13
Dictyostelium discoideum DDB_G0267508   UPF0041 family protein
Drosophila melanogaster Dmel_CG14290   Mitochondrial pyruvate carrier
Echinococcus granulosus EgrG_000626600   Brain protein 44 protein
Echinococcus multilocularis EmuJ_000626600   Brain protein 44 protein
Homo sapiens ENSG00000060762   mitochondrial pyruvate carrier 1
Homo sapiens 347411   mitochondrial pyruvate carrier 1-like
Leishmania braziliensis LbrM.01.0380   hypothetical protein, conserved
Leishmania donovani LdBPK_010350.1   Mitochondrial pyruvate carrier 1
Leishmania infantum LinJ.01.0350   hypothetical protein, conserved
Leishmania major LmjF.01.0335   hypothetical protein, conserved
Leishmania mexicana LmxM.01.0335   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04969   repeating small protein
Mus musculus 667103   predicted gene 13570
Mus musculus ENSMUSG00000023861   mitochondrial pyruvate carrier 1
Neospora caninum NCLIV_050160   cDNA, FLJ92180, highly similar to Homo sapiens brain protein 44 (BRP44), mRNA, related
Oryza sativa 4345559   Os08g0412500
Oryza sativa 4346901   Os09g0373000
Onchocerca volvulus OVOC8568   Putative mitochondrial pyruvate carrier 2
Plasmodium berghei PBANKA_1354200   mitochondrial pyruvate carrier protein 1, putative
Plasmodium falciparum PF3D7_1340800   mitochondrial pyruvate carrier protein 1, putative
Plasmodium knowlesi PKNH_1260600   mitochondrial pyruvate carrier protein 1, putative
Plasmodium vivax PVX_082955   mitochondrial pyruvate carrier protein 1, putative
Plasmodium yoelii PY07365   hypothetical protein
Saccharomyces cerevisiae YGL080W   Fmp37p
Schistosoma japonicum Sjp_0212100   Brain protein 44-like protein, putative
Schistosoma mansoni Smp_022430   hypothetical protein
Trypanosoma brucei gambiense Tbg972.9.1990   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.3780   Mitochondrial pyruvate carrier 1
Trypanosoma cruzi TcCLB.509337.19   Mitochondrial pyruvate carrier 1
Trypanosoma cruzi TcCLB.511577.144   Mitochondrial pyruvate carrier 1
Toxoplasma gondii TGME49_235880   brain protein 44 family protein
Theileria parva TP02_0542   hypothetical protein, conserved

Essentiality

LmjF.01.0335 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.2380 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.2380 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.160.2380 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.160.2380 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_235880 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.01.0335 (Leishmania major), hypothetical protein, conserved
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