Detailed view for LmjF.16.0340

Basic information

TDR Targets ID: 25487
Leishmania major, 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.4524 | Length (AA): 169 | MW (Da): 19307 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05241   Emopamil binding protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005783   endoplasmic reticulum  
GO:0047750   cholestenol delta-isomerase activity  
GO:0016125   sterol metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_155655)

Species Accession Gene Product
Leishmania donovani LdBPK_160350.1   3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative
Leishmania infantum LinJ.16.0350   3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative;with=GeneDB:LmjF16.0340
Leishmania major LmjF.16.0340   3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative
Leishmania mexicana LmxM.16.0340   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506743.200   3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative
Trypanosoma cruzi TcCLB.509253.30   3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0269 0.3409 0.315
0.0421 0.2739 0.2739
0.056 0.2888 0.2885
0.0296 0.3606 0.3562
0.0134 0.2927 0.3474
0.0271 0.5126 1
0.0433 0.2735 0.2732
0.0417 0.2767 0.2751
0.0313 0.364 0.359
0.0152 0.3578 0.3422
0.0138 1 1
0.0283 0.2949 0.3605
0.0936 0.2777 0.2735
0.0267 0.3285 0.3613
0.0443 0.5184 1
0.1416 0.3294 0.4072
0.0135 1 1
0.028 0.2954 0.3605
0.029 0.3673 0.3628
0.0287 0.2969 0.3605
0.0286 0.3665 0.356
0.0146 0.5689 1
0.028 0.2928 0.3605
0.0146 1 1
0.0278 0.3304 0.5905
0.027 0.3147 0
0.0149 0.3481 0.347
0.0287 0.3568 0.3568
0.0406 0.2742 0.2742
0.029 0.3501 0.3394
0.0147 0.6003 1
0.0406 0.2742 0.2742
0.0406 0.2742 0.2742
0.0406 0.2742 0.2742
0.0267 0.2906 0.3598
0.0158 0.3381 0.3249
0.0424 0.2763 0.2763
0.0166 0.3347 0.3347
0.0276 0.2871 0.3605
0.1168 0.3273 0.3261
0.0133 0.3338 1
0.0136 1 0.5
0.0422 0.3689 0.3684
0.0406 0.2742 0.2742
0.0406 0.2742 0.2742
0.0267 0.2954 0.3626
0.0428 0.4985 1
0.1416 0.3294 0.4072
0.014 0.3213 0
0.0542 0.3649 0.3734
0.0285 0.3092 0.7829
0.0166 0.3398 0.3378
0.0849 1 0.5
0.0447 1 1
0.0157 0.2965 0.2367
0.0147 0.3152 0.3313
0.0308 0.3614 0.3586
0.0429 0.278 0.2763
0.0416 0.2554 0.2686
0.0166 0.6449 0.82
0.0414 0.2786 0.3692
0.0415 0.3601 0.3601
0.0303 0.2876 0
0.0406 0.2742 0.2742
0.0536 0.3683 0.3674
0.028 0.3423 0
0.0406 0.2742 0.2742
0.0429 0.278 0.2763
0.0278 0.3463 0
0.0135 0.2903 0.3386
0.0166 0.6449 0.82
0.0164 0.3476 0.3433
0.0133 0.3338 1
0.0136 0.3038 0
0.1416 0.3294 0.4072
0.0267 0.2928 0.3605
0.0283 0.2949 0.3605
0.0166 0.3334 0.3275
0.0136 0.2991 1
0.0276 0.2934 0.3605
0.0273 0.2941 0.3605
0.0278 0.3304 0.5905
0.016 1 0.5
0.0708 0.2965 0.2953
0.0283 0.2523 0.2523
0.0976 0.2603 0.2603
0.0445 0.363 0.3571
0.0277 0.3269 0.3591
0.0149 0.3481 0.347
0.0302 0.6055 0.8163
0.0418 0.2725 0.2714
0.0138 0.6883 1
0.0406 0.2742 0.2742
0.0302 0.6055 0.8163
0.0422 0.2656 0.2656
0.0412 0.2723 0.2723
0.0406 0.2742 0.2742
0.0406 0.2742 0.2742
0.0135 0.3231 0.3466
0.0284 0.36 0
0.0272 0.2977 0
0.0406 0.2742 0.2742
0.0273 0.2949 0.3605
0.0285 0.3376 0.3376
0.0138 0.4173 1
0.0292 0.33 0.33
0.0426 0.3668 0.3634
0.028 0.3423 0
0.0133 0.2967 0.3442
0.0143 0.2938 0
0.0283 0.2951 0.3605
0.0429 0.278 0.2763
0.0291 0.3387 0
0.0314 0.3232 0
0.0276 0.2958 0.3642
0.0411 0.2755 0.2739
0.0267 0.3591 0.359
0.0274 0.3071 0.2715
0.0276 0.2934 0.3605
0.0156 0.5289 1
0.0166 0.2687 0.329
0.0133 0.3458 0.3458
0.0406 0.2755 0.2739
0.0135 0.3462 0.3399
0.0266 0.6263 0.7337
0.0166 0.3398 0.3378
0.0277 0.3269 0.3591
0.0278 0.3018 0
0.0406 0.2742 0.2742
0.0451 0.3582 0
0.0406 0.2742 0.2742
0.0136 0.6075 1
0.042 0.5262 1
0.0144 0.3068 0
0.028 0.2928 0.3605
0.0406 0.2742 0.2742
0.0296 0.3423 0.3423
0.045 0.3594 0.355
0.015 0.2965 0.2367
0.0704 0.2911 0
0.0411 0.2696 0.2694
0.0272 0.3027 0
0.0267 0.2906 0.3598
0.0273 0.3977 1
0.0141 0.3118 1
0.0406 0.2742 0.2742
0.0276 0.2928 0.3605
0.0281 0.2848 0.3568
0.0138 0.2958 1
0.0149 0.5698 1
0.0273 0.2702 0.3584
0.0426 0.3668 0.3634
0.0276 0.2934 0.3605
0.0444 1 1
0.0156 0.307 1
0.0166 1 0.5
0.0276 0.2934 0.3605
0.0424 0.2763 0.2763
0.0266 0.2646 0.3328
0.0307 0.3492 0
0.0291 0.3476 0
0.0166 0.6449 0.82
0.0149 0.31 0.3505
0.0424 0.2765 0.2763
0.0443 0.2756 0.2742
0.0137 0.2745 0.3558
0.0276 0.2871 0.3605
0.0402 0.3456 0.3209
0.0149 0.2761 0
0.0137 0.3878 0.7382
0.0138 0.3388 0.3376
0.0273 0.2951 0.3605
0.0136 0.3254 0.3254
0.0273 0.2949 0.3605
0.027 0.3095 0
0.028 0.258 0
0.0406 0.2742 0.2742
0.0424 0.2696 0.2584
0.0297 0.3565 0.3474
0.015 0.2947 0.2367
0.0565 0.3693 0.3692
0.0284 0.2838 0.366
0.1019 0.3143 0.3113
0.0133 0.3442 0.344
0.0149 0.3481 0.347
0.0452 0.3674 0.3671
0.0166 0.3347 0.3347
0.0267 0.3273 0.3605
0.0266 0.2928 0.3605
0.0144 0.253 1
0.0742 0.2704 0.269
0.0166 0.3632 0.3357
0.0152 0.7055 1
0.0146 0.3891 1
0.0435 0.2786 0.2763
0.0277 0.3269 0.3591
0.0157 0.309 1
0.1453 0.2919 0.2918
0.028 0.258 0
0.0138 0.2961 1
0.0402 0.3456 0.3209
0.0152 0.7055 1
0.0166 0.3334 0.3275
0.0284 0.2838 0.366
0.0135 0.3563 0.3563
0.0277 0.2949 0.3605
0.027 0.3589 0.3533
0.0686 0.4293 1
0.0704 0.2572 0.2498
0.0278 0.3613 0.3547
0.0437 0.2742 0.2742
0.0266 0.2646 0.3328
0.0137 0.3878 0.7382
0.0302 0.6055 0.8163
0.0285 0.3477 0
0.029 0.7936 0.7936
0.027 0.2951 0.3605
0.1416 0.3294 0.4072
0.0283 0.2932 0.3605
0.0138 0.3388 0.3376
0.0279 0.3393 0
0.0276 0.2934 0.3605
0.0166 0.3347 0.3347
0.0167 0.3703 0.3689
0.0273 0.2623 0.3579
0.028 0.258 0
0.0406 0.2742 0.2742
0.0276 0.2934 0.3605
0.028 0.2949 0.3605
0.0276 0.2949 0.3605
0.0142 0.5638 1
0.0165 0.4153 1
0.0142 0.3222 1
0.0424 0.2778 0.2763
0.0284 0.3299 0
0.0284 0.2838 0.366
0.0147 0.3305 0
0.028 0.258 0
0.0269 0.2679 0.7341
0.0269 0.3409 0.315
0.0138 0.3468 0.3209
0.0135 0.5927 1
0.0399 0.2664 0.272
0.0149 0.2955 0.1874
0.0266 0.6106 0.706
0.0416 0.2755 0.2739
0.0273 0.2951 0.3605

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LmjF.16.0340 (Leishmania major), 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative
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