pI: 7.4639 |
Length (AA): 362 |
MW (Da): 38908 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
15 | 361 | 5h82 (A) | 6 | 366 | 38.00 | 0 | 1 | 1.41506 | -0.33 |
19 | 360 | 5vkt (A) | 9 | 353 | 45.00 | 0 | 1 | 1.55535 | -0.91 |
20 | 362 | 1uuf (A) | 3 | 347 | 51.00 | 0 | 1 | 1.59711 | -0.7 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126661)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G34230 | cinnamyl alcohol dehydrogenase 5 |
Arabidopsis thaliana | AT2G21730 | cinnamyl alcohol dehydrogenase 2 |
Arabidopsis thaliana | AT4G37980 | cinnamyl alcohol dehydrogenase 7 |
Arabidopsis thaliana | AT4G39330 | putative cinnamyl alcohol dehydrogenase 9 |
Arabidopsis thaliana | AT3G19450 | cinnamyl alcohol dehydrogenase 4 |
Arabidopsis thaliana | AT4G37970 | cinnamyl-alcohol dehydrogenase 6 |
Arabidopsis thaliana | AT2G21890 | cinnamyl alcohol dehydrogenase-like protein 3 |
Arabidopsis thaliana | AT4G37990 | cinnamyl alcohol dehydrogenase 8 |
Candida albicans | CaO19.11480 | immunogenic alcohol dehydrogenase |
Candida albicans | CaO19.5113 | alcohol dehydrogenase 2 |
Candida albicans | CaO19.12579 | alcohol dehydrogenase 2 |
Candida albicans | CaO19.3997 | immunogenic alcohol dehydrogenase |
Candida albicans | CaO19.12963 | similar to S. cerevisiae ADH7 (YCR105W) and ADH6 (YMR318C) medium chain alcohol dehydrogenases |
Candida albicans | CaO19.5517 | similar to S. cerevisiae ADH7 (YCR105W) and ADH6 (YMR318C) medium chain alcohol dehydrogenases |
Caenorhabditis elegans | CELE_K12G11.3 | Protein SODH-1 |
Caenorhabditis elegans | CELE_K12G11.4 | Protein SODH-2 |
Caenorhabditis elegans | CELE_D2063.1 | Protein D2063.1 |
Cryptosporidium hominis | Chro.50110 | ENSANGP00000000281 |
Cryptosporidium parvum | cgd5_2670 | predicted mannitol dehydrogenase; zinc dependent alcohol dehydrogenase like rossmann fold |
Dictyostelium discoideum | DDB_G0271680 | zinc-containing alcohol dehydrogenase |
Dictyostelium discoideum | DDB_G0272628 | zinc-containing alcohol dehydrogenase |
Dictyostelium discoideum | DDB_G0273155 | zinc-containing alcohol dehydrogenase |
Dictyostelium discoideum | DDB_G0273921 | zinc-containing alcohol dehydrogenase |
Dictyostelium discoideum | DDB_G0268322 | zinc-containing alcohol dehydrogenase |
Dictyostelium discoideum | DDB_G0274085 | zinc-containing alcohol dehydrogenase |
Dictyostelium discoideum | DDB_G0271740 | zinc-containing alcohol dehydrogenase |
Dictyostelium discoideum | DDB_G0271780 | zinc-containing alcohol dehydrogenase |
Escherichia coli | b0325 | aldehyde reductase, NADPH-dependent, Zn-containing, broad specificity |
Escherichia coli | b4269 | aldehyde reductase, NADPH-dependent, Zn-containing, broad specificity |
Escherichia coli | b1478 | ethanol-active dehydrogenase/acetaldehyde-active reductase |
Leishmania braziliensis | LbrM.23.0400 | NADP-dependent alcohol dehydrogenase, putative |
Leishmania donovani | LdBPK_230410.1 | NADP-dependent alcohol dehydrogenase, putative |
Leishmania infantum | LinJ.23.0410 | NADP-dependent alcohol dehydrogenase, putative |
Leishmania major | LmjF.23.0360 | NADP-dependent alcohol dehydrogenase, putative |
Leishmania mexicana | LmxM.23.0360 | NADP-dependent alcohol dehydrogenase, putative |
Mycobacterium leprae | ML2053c | Probable alcohol dehydrogenase AdhA |
Mycobacterium leprae | ML1730 | PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC |
Mycobacterium tuberculosis | Rv1862 | Probable alcohol dehydrogenase AdhA |
Mycobacterium tuberculosis | Rv3045 | Probable NADP-dependent alcohol dehydrogenase AdhC |
Mycobacterium ulcerans | MUL_2965 | NADP-dependent alcohol dehydrogenase AdhC |
Mycobacterium ulcerans | MUL_3015 | alcohol dehydrogenase AdhA |
Mycobacterium ulcerans | MUL_0495 | Zn-dependent alcohol dehydrogenase, AdhX |
Mycobacterium ulcerans | MUL_1885 | NADP-dependent alcohol dehydrogenase Adh |
Oryza sativa | 9271744 | Os08g0270433 |
Oryza sativa | 4328552 | Os02g0187800 |
Oryza sativa | 4348690 | Os10g0430200 |
Oryza sativa | 9269515 | Os09g0400300 |
Oryza sativa | 9267509 | Os08g0270466 |
Oryza sativa | 4335223 | Os04g0229100 |
Oryza sativa | 4346989 | Os09g0400000 |
Oryza sativa | 4336968 | Os04g0612700 |
Oryza sativa | 4346988 | Os09g0399800 |
Oryza sativa | 9266669 | Os03g0223200 |
Oryza sativa | 4346993 | Os09g0400400 |
Saccharomyces cerevisiae | YMR318C | Adh6p |
Saccharomyces cerevisiae | YMR083W | alcohol dehydrogenase ADH3 |
Saccharomyces cerevisiae | YMR303C | alcohol dehydrogenase ADH2 |
Saccharomyces cerevisiae | YOL086C | alcohol dehydrogenase ADH1 |
Saccharomyces cerevisiae | YBR145W | alcohol dehydrogenase ADH5 |
Saccharomyces cerevisiae | YCR105W | Adh7p |
Trypanosoma cruzi | TcCLB.504339.19 | NADP-dependent alcohol hydrogenase, putative |
Trypanosoma cruzi | TcCLB.508677.80 | NADP-dependent alcohol hydrogenase, putative |
Trypanosoma cruzi | TcCLB.504425.60 | NADP-dependent alcohol hydrogenase, putative |
Trypanosoma cruzi | TcCLB.509331.210 | NADP-dependent alcohol hydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1892 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu3098 | Mycobacterium tuberculosis | non-essential | nmpdr |
b0325 | Escherichia coli | non-essential | goodall |
b1478 | Escherichia coli | non-essential | goodall |
b4269 | Escherichia coli | non-essential | goodall |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Target | Type | Source | Notes |
---|---|---|---|
ML1730 | cloned gene | BRENDA | A gene with this EC number or name or sequence has been cloned from Mycobacterium bovis ( 1 ) |