Detailed view for ML2507c

Basic information

TDR Targets ID: 255869
Mycobacterium leprae, PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE)
Source Database / ID:  Leproma 

pI: 5.2262 | Length (AA): 190 | MW (Da): 20789 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00692   dUTPase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008829   dCTP deaminase activity  
GO:0006229   dUTP biosynthetic process  

Metabolic Pathways

Pyrimidine metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 189 2qxx (A) 1 189 90.00 0 1 2.08054 -0.94

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 2QLP:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2QXX:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131757)

Species Accession Gene Product
Chlamydia trachomatis CT_039   deoxycytidine triphosphate deaminase
Dictyostelium discoideum DDB_G0268194   dCTP deaminase
Dictyostelium discoideum DDB_G0293580   dCTP deaminase
Escherichia coli b2065   2'-deoxycytidine 5'-triphosphate deaminase
Entamoeba histolytica EHI_140240   deoxycytidine triphosphate deaminase, putative
Mycobacterium leprae ML2507c   PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE)
Mycobacterium tuberculosis Rv0321   Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)
Mycobacterium ulcerans MUL_0560   deoxycytidine triphosphate deaminase
Wolbachia endosymbiont of Brugia malayi Wbm0292   deoxycytidine triphosphate deaminase

Essentiality

ML2507c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2065 Escherichia coli essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.042 0.345 0.5
0.0245 0.2896 1
0.048 0.3455 0.5
0.0412 0.3415 1
0.1316 0.3429 1
0.1145 0.3416 1
0.0191 0.3223 1
0.1213 0.3435 1
0.1389 0.3459 1
0.0269 0.3287 1
0.0115 0.3074 0.5
0.0424 0.2855 0.5
0.0348 0.3392 1
0.0115 0.3095 0.5
0.0142 0.2583 0.5
0.0078 0.3348 0.5
0.0283 0.331 0.5
0.0426 0.3441 1
0.0245 0.265 0.5
0.0313 0.2938 1
0.0356 0.2523 1
0.1262 0.3441 1
0.0115 0.3095 0.5
0.0329 0.3398 0.5
0.041 0.3223 1
0.0473 0.3298 0.5
0.048 0.3455 0.5
0.0392 0.338 0.5
0.0356 0.2516 1
0.0245 0.276 1
0.0335 0.3365 1
0.0272 0.2645 1
0.0499 0.3416 0.5
0.0175 0.3303 1
0.0271 0.3106 1
0.0359 0.3149 0.5
0.0253 0.2674 1
0.0149 0.3386 0.5
0.0245 0.2896 1
0.0113 0.3156 0.5
0.1311 0.3421 0.5
0.1233 0.34 0.5
0.1389 0.3459 1
0.0356 0.2521 1
0.0418 0.3414 0.5
0.0211 0.3378 1
0.1285 0.338 0.5
0.1267 0.3447 1
0.0273 0.343 0.5
0.1316 0.3429 1
0.0335 0.3365 1
0.1389 0.3459 1
0.0242 0.2879 0.5
0.0286 0.324 1
0.1233 0.3456 1
0.0382 0.3006 0.5
0.0279 0.3437 0.5
0.0418 0.3414 0.5
0.0467 0.3081 1
0.1186 0.3105 0.5
0.0424 0.2855 0.5
0.0467 0.3081 1
0.0374 0.3399 0.5
0.0287 0.3379 1
0.0409 0.3389 1
0.0623 0.3404 1
0.0308 0.3349 0.5
0.03 0.3388 1
0.1267 0.3447 1
0.0567 0.338 0.5
0.033 0.3069 0.5
0.0303 0.3434 1
0.0616 0.3451 1
0.129 0.3446 0.5
0.0333 0.3339 1
0.0644 0.3384 1
0.0111 0.2527 1
0.0299 0.3287 1
0.0107 0.282 1
0.0412 0.3415 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier ML2507c (Mycobacterium leprae), PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE)
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