Detailed view for ML1044

Basic information

TDR Targets ID: 256418
Mycobacterium leprae, PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)
Source Database / ID:  Leproma 

pI: 4.7335 | Length (AA): 451 | MW (Da): 46580 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01593   Flavin containing amine oxidoreductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0009055   electron carrier activity  
GO:0004729   protoporphyrinogen oxidase activity  
GO:0055114   oxidation reduction  
GO:0006779   porphyrin biosynthetic process  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 448 3lov (A) 1 463 29.00 0 1 1.30645 0.21
2 41 4ylf (B) 139 175 30.00 0.5 0.43 0.333792 -0.2
2 451 2jae (A) 11 488 17.00 0 1 1.08788 0.72
5 44 2gmh (A) 37 79 30.00 0.85 0.09 0.232792 0.57
107 221 4xg0 (A) 258 371 42.00 0.7 0.94 0.533089 0.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129066)

Species Accession Gene Product
Arabidopsis thaliana AT5G14220   protoporphyrinogen oxidase-like protein
Arabidopsis thaliana AT4G01690   protoporphyrinogen oxidase
Candida albicans CaO19.4747   protoporphyrinogen oxidase
Candida albicans CaO19.12209   protoporphyrinogen oxidase, heme biosynthesis
Chlamydia trachomatis CT_745   protoporphyrinogen oxidase
Dictyostelium discoideum DDB_G0292040   protoporphyrinogen oxidase
Drosophila melanogaster Dmel_CG5796   Protoporphyrinogen oxidase
Echinococcus granulosus EgrG_000615800   protoporphyrinogen oxidase
Echinococcus multilocularis EmuJ_000615800   protoporphyrinogen oxidase
Homo sapiens ENSG00000143224   protoporphyrinogen oxidase
Mycobacterium leprae ML1044   PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)
Mus musculus ENSMUSG00000062729   protoporphyrinogen oxidase
Mycobacterium tuberculosis Rv2677c   Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO)
Mycobacterium ulcerans MUL_3311   protoporphyrinogen oxidase
Oryza sativa 4327918   Os01g0286600
Saccharomyces cerevisiae YER014W   oxygen-dependent protoporphyrinogen oxidase
Schistosoma japonicum Sjp_0048650   ko:K00231 protoporphyrinogen oxidase [EC1.3.3.4B], putative
Schistosoma mansoni Smp_068250   Protoporphyrinogen oxidase chloroplast/mitochondrial precursor
Schmidtea mediterranea mk4.008512.02   Putative protoporphyrinogen oxidase,chloroplast/mitochondrial
Schmidtea mediterranea mk4.002644.04   Putative protoporphyrinogen oxidase,chloroplast/mitochondrial

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Nicotiana tabacum Protoporphyrinogen oxidase, mitochondrial Compounds References
Zea mays Protoporphyrinogen IX oxidase Compounds References
Nicotiana tabacum Protoporphyrinogen oxidase, chloroplastic Compounds References
Homo sapiens protoporphyrinogen oxidase Compounds References
Arabidopsis thaliana protoporphyrinogen oxidase Compounds References
Zea mays Protoporphyrinogen IX oxidase Compounds References
Bacillus subtilis (strain 168) Protoporphyrinogen oxidase Compounds References
Oryza sativa Os01g0286600 Compounds References
Cichorium intybus Protoporphyrinogen IX oxidase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0162 0.5328 0.5
0.1017 1 0.5
0.2094 0.2529 1
0.0137 0.7284 0.5
0.1121 1 0.5
0.2138 1 0.5
0.2726 0.925 1
0.0156 1 0.5
0.3478 1 1
0.0835 1 0.5
0.2275 1 0.5
0.1356 0.9837 1
0.071 0.6134 1
0.0158 1 0.5
0.0306 0.3354 1
0.107 1 0.5
0.1453 1 1
0.0479 0.3911 1
0.014 0.9532 1
0.237 1 1
0.0177 0.4028 0.5
0.0487 1 0.5
0.1305 1 0.5
0.7353 0.7158 0.5
0.0481 1 1
0.0918 0.4305 1
0.2855 1 0.5
0.1588 1 0.5
0.1003 1 0.5
0.2066 1 0.5
0.1133 1 1
0.1355 0.2763 1
0.0331 1 0.5
0.0979 0.5721 0.5
0.0991 1 0.5
0.0409 0.2708 1
0.2006 1 0.5
0.2726 0.925 1
0.2214 1 0.5
0.1672 1 0.5
0.0747 1 0.5
0.1027 0.5406 0.5
0.0476 0.4737 0.5
0.118 1 0.5
0.182 1 0.5
0.0473 1 0.5
0.0657 0.2925 1
0.0326 1 1
0.1838 0.6416 1
0.2574 0.3318 1
0.3429 1 1
0.0192 0.7705 1
0.0192 1 0.5
0.0192 1 1
0.7316 0.974 1
0.2502 1 0.5
0.2018 1 0.5
0.0384 1 0.5
0.1838 0.6416 1
0.0627 1 1
0.0669 1 1
0.016 0.3934 1
0.2488 1 0.5
0.0302 0.8952 1
0.0348 0.3447 1
0.5146 1 0.5
0.0502 1 0.5
0.0384 1 0.5
0.0337 1 0.5
0.0366 1 0.5
0.0192 0.3176 0.5
0.0192 1 0.5
0.0644 1 0.5
0.0262 1 0.5
0.0315 1 0.5
0.0154 1 0.5
0.1838 0.6412 1
0.2021 0.2663 1
0.0162 1 1
0.0478 0.2943 0.5
0.0346 1 0.5
0.1783 1 0.5
0.0313 0.5641 1
0.0192 1 0.5
0.0063 1 0.5
0.2215 0.7183 1
0.0023 0.5 0.5
0.0365 0.2681 1
0.047 1 0.5
0.0342 1 0.5
0.0192 1 0.5
0.2255 1 0.5
0.1194 1 0.5
0.1682 0.2761 0.5
0.2094 0.2529 1
0.0108 1 0.5
0.0325 1 1
0.0634 1 0.5
0.0723 0.8709 0.5
0.0384 1 0.5
0.0192 0.4713 0.5
0.1356 0.9837 1
0.0384 0.3746 1
0.0192 0.3314 0.5
0.0325 1 0.5
0.0308 0.4964 1
0.0471 1 0.5
0.0192 0.4294 1
0.2215 0.7183 1
0.2277 1 0.5
0.0665 1 0.5
0.0534 1 0.5
0.0367 1 1
0.0154 0.5727 1
0.0518 0.6312 1
0.1356 0.9837 1
0.1545 1 0.5
0.0192 0.7178 1
0.0192 0.5066 0.5
0.2347 1 1
0.0786 1 0.5
0.2024 1 0.5
0.0979 0.5721 0.5
0.0172 0.2689 0.2537
0.0827 0.8786 1
0.0192 1 0.5
0.0192 0.8247 1
0.2087 1 1
0.2574 0.3318 1
0.0817 1 0.5
0.2248 1 1
0.1838 0.6416 1
0.1766 0.4771 1
0.0254 1 0.5
0.0337 1 0.5
0.0384 0.4627 1
0.0192 1 0.5
0.0528 1 0.5
0.0192 1 0.5
0.0131 0.5 0.5
0.1003 1 1
0.2094 0.2529 1
0.0563 1 0.5
0.067 0.637 1
0.0723 0.8709 0.5
0.1648 1 1
0.1193 1 0.5
0.0192 0.4021 0
0.0669 0.6772 0.5
0.1516 1 1
0.0157 1 0.5
0.3478 1 1
0.0352 1 0.5
0.2124 0.3109 0.9279
0.0192 0.4294 1
0.0516 1 0.5
0.0157 1 0.5
0.1838 0.6416 1
0.011 0.3084 0.5
0.0313 0.5641 1
0.0192 1 0.5
0.086 1 0.5
0.1156 1 0.5
0.0064 1 0.5
0.0384 1 0.5
0.2653 1 0.5
0.3943 0.9936 1
0.1218 0.4552 1
0.0168 0.3772 0.3772
0.0328 0.5942 1
0.0192 1 0.5
0.2094 0.2529 1
0.1555 0.8786 0.5
0.0314 0.8318 1
0.071 0.6134 1
0.5607 1 0.5
0.494 1 1
0.0192 1 0.5
0.0703 0.3161 1
0.2483 1 0.5
0.0327 0.3033 0.5
0.0109 1 0.5
0.2205 1 0.5
0.2041 1 0.5
0.1748 1 1
0.0632 0.3229 0.6955
0.1528 0.6216 1
0.2711 1 1
0.1516 1 0.5
0.0657 0.2925 1
0.2383 1 1
0.2172 1 0.5
0.1766 0.4771 1
0.0361 0.726 0.5
0.0842 1 0.5
0.0156 0.3173 0.5
0.1092 1 1
0.0048 0.6551 1
0.079 0.2834 1
0.1722 1 0.5
0.2186 1 1
0.0727 1 0.5
0.2316 0.264 1
0.1659 1 0.5
0.2909 1 0.5
0.1951 1 0.5
0.0192 0.2978 1
0.0502 0.2984 1
0.3054 0.3226 1
0.2504 1 1
0.0192 0.5683 0.5
0.0841 1 0.5
0.0857 1 0.5
0.0486 1 1
0.0192 0.4535 0.5
0.2305 1 0.5
0.1587 1 0.5
0.1422 1 0.5
0.0782 1 0.5
0.067 0.637 1
0.0887 0.3349 1
0.2094 0.2529 1
0.0732664 0.542611 0.5
0.0637 1 0.5
0.0161 0.376 0.376
0.048 1 0.5
0.1525 0.2634 1
0.0657 0.2925 1
0.0349 0.363 0.5
0.0662 0.6371 0.5
0.1355 0.2763 1
0.2971 1 1
0.685 1 0.5
0.0192 0.3291 0.5
0.2504 1 1
0.2798 1 0.5
0.0703 0.449 1
0.1838 0.6416 1
0.2036 1 0.5
0.0669 1 0.5
0.0363 0.5248 1
0.1838 0.6416 1
0.2087 1 1
0.0192 1 0.5
0.0782 1 0.5
0.1369 0.554 1
0.0821 1 0.5
0.0063 1 0.5
0.0186 1 0.5
0.0192 1 0.5
0.2254 1 0.5
0.067 0.637 1
0.237 1 1
0.2488 1 0.5
0.2383 1 1
0.1583 1 0.5
0.0384 0.3746 1
0.2574 0.3318 1
0.0826 0.4209 1
0.2821 1 0.5
0.1465 1 0.5
0.0384 1 0.5
0.0162 0.8915 1
0.0154 0.2666 0.5
0.0842 1 0.5
0.0217 1 1
0.1545 1 0.5
0.0501 0.75 1
0.0747 1 0.5
0.0159 1 0.5
0.0041 1 0.5
0.0272 1 0.5
0.0192 0.4974 0.5
0.0192 0.5287 1
0.2347 1 1
0.1766 0.4771 1
0.1073 1 0.5
0.1949 1 0.5
0.1766 0.4771 1
0.0178 1 0.5
0.0192 0.2869 0.5
0.0947 1 1
0.0179 0.2705 0.2705
0.0743 1 0.5
0.07 0.8525 0.5
0.1355 0.2763 1
0.0774 1 0.5
0.2031 1 0.5
0.013 1 0.5
0.0977 0.9974 0.5
0.0311 1 0.5
0.0534 1 0.5
0.0335 1 0.5
0.2316 0.264 1
0.0062 1 0.5
0.0667 1 0.5
0.0186 1 0.5
0.0023 0.5 0.5
0.5843 1 0.5
0.0439 0.3516 0.5
0.138 1 1
0.3905 1 1
0.1766 0.4771 1
0.0738 1 0.5
0.0188 0.4974 1
0.1399 0.8435 1
0.0349 0.363 0.5
0.1682 0.2761 0.5
0.0192 1 0.5
0.2094 0.2529 1
0.0702 0.8698 1
0.2726 0.925 1
0.0186 0.3419 0.9982
0.0192 0.8123 1
0.0828 1 0.5
0.2313 1 0.5
0.0834 1 0.5
0.1807 0.9659 1
0.0158 1 0.5
0.2094 0.2529 1
0.0792 1 0.5
0.1356 0.9837 1
0.1693 1 1
0.2373 1 0.5
0.0192 1 0.5
0.2449 1 0.5
0.2175 1 0.5
0.0086 0.5 0.5
0.3277 1 0.5
0.1754 1 1
0.0329 0.3293 0.5
0.2574 0.3318 1
0.0477 1 0.5
0.2307 1 0.5
0.0156 0.3173 0.5
0.6373 1 1
0.0313 1 0.5
0.0522 0.6549 0.5
0.0822 1 0.5
0.1807 0.9659 1
0.0192 0.628 1
0.1766 0.4771 1
0.1521 1 0.5
0.2094 0.2529 1
0.0576 1 0.5
0.2094 0.2529 1
0.049 1 0.5
0.2789 1 0.5
0.1961 1 0.5
0.2013 1 0.5
0.0186 0.3419 0.9982
0.1178 1 0.5
0.0738 1 0.5
0.1764 1 0.5
0.1931 1 1
0.0042 0.5 0.5
0.1636 1 0.5
0.1753 1 0.5
0.0065 1 0.5
0.1361 1 1
0.0192 1 0.5
0.0816 0.9785 1
0.1355 0.2763 1
0.0845 1 0.5
0.0192 1 0.5
0.3782 0.4109 1
0.0192 1 0.5
0.0165 0.3314 0.5
0.0342 1 0.5
0.0554 0.3286 1
0.0192 0.7629 0.5
0.1754 1 1
0.0178 1 0.5
0.1872 1 0.5
0.0051 1 0.5
0.0192 0.3444 1
0.3478 1 1
0.2205 1 0.5
0.0534 0.542 0.5
0.0791 1 0.5
0.0282 0.5 0.5
0.1583 1 0.5
0.0156 0.9674 1
0.0629 1 0.5
0.3478 1 1
0.1583 1 0.5
0.1087 1 1
0.138 1 1
0.0192 0.2755 0.5
0.0384 0.5551 1
0.0842 1 0.5
0.2284 1 0.5
0.0314 0.8318 1
0.2063 1 0.5
0.1073 1 0.5
0.0192 1 0.5
0.1931 1 1
0.0345 1 0.5
0.0192 1 0.5
0.0576 1 0.5
0.2464 0.9724 1
0.0192 0.5999 0.5
0.0421 1 0.5
0.1838 1 1
0.0192 0.4125 0.5
0.0629 0.7409 1
0.0384 1 0.5
0.0863 1 0.5
0.1971 1 1
0.0932 0.9513 1
0.1766 0.4771 1
0.0154 0.6806 0.5
0.0164 1 0.5
0.1501 1 0.5
0.2111 1 0.5
0.0654 1 0.5
0.1583 1 0.5
0.0345 0.2854 1
0.0808 1 0.5
0.0365 0.2681 1
0.0971 1 0.5
0.0169 0.8273 0.5
0.0192 1 0.5
0.2111 1 0.5
0.162 1 0.5
0.0333 1 0.5
0.1108 1 0.5
0.1899 1 0.5
0.0159 1 0.5
0.0702 0.8698 1
0.1583 1 0.5
0.0192 0.8105 0.5
0.0685 1 0.5
0.0782 1 0.5
0.0192 0.3601 0.5
0.2656 1 0.5
0.0842 1 0.5
0.091 1 1
0.0312 1 1
0.2486 1 0.5
0.0899 0.9163 1
0.0384 1 0.5
0.0629 0.2754 1
0.0854 1 0.5
0.138 1 1
0.0702 0.436 1
0.0165 0.3314 0.5
0.0025 0.4128 0.5
0.0359 1 0.5
0.0333 1 0.5
0.1182 1 0.5
0.0524 0.4919 1
0.2588 1 0.5
0.0662 0.6371 0.5
0.0392 0.3483 1
0.1872 1 0.5
0.0192 1 0.5
0.1139 1 0.5
0.0384 0.3746 1
0.1498 1 0.5
0.0192 0.5456 1
0.2031 0.2712 1
0.1356 0.9837 1
0.0192 0.5 0.5
0.1873 1 0.5
0.0392 0.3483 1
0.0847 1 0.5
0.0776 1 0.5
0.0192 0.5518 1
0.2588 1 0.5
0.1583 1 0.5
0.2225 1 0.5
0.082 1 0.5
0.0824 1 0.5
0.0663 1 0.5
0.0192 0.3491 1
0.0824 1 0.5
0.0823 1 0.5
0.0346 1 0.5
0.0345 1 0.5
0.0384 1 0.5
0.1874 1 0.5
0.0918 0.4305 1
0.0255 0.6236 0.5
0.0173 0.551 1
0.1228 1 0.5
0.0192 1 0.5
0.0905 1 0.5
0.2755 1 0.5
0.035 1 1
0.0384 1 0.5
0.1383 1 1
0.1754 1 1
0.0192 0.6714 0.5
0.0192 1 0.5
0.0865 1 0.5
0.0487 1 0.5
0.1487 1 0.5
0.0302 1 0.5
0.0165 0.3314 0.5
0.0654 1 0.5
0.0192 1 0.5
0.0322 1 0.5
0.0419 1 0.5
0.0192 1 0.5
0.0498 1 0.5
0.035 1 0.5
0.0365 0.2681 1
0.0904 0.3786 1
0.1138 1 0.5
0.1528 0.6216 1
0.0192 1 0.5
0.16 1 0.5
0.0169 0.3667 0.5
0.2094 0.2529 1
0.0192 0.3942 0.5
0.2086 1 0.5
0.0786 1 0.5
0.0192 0.4656 0.5
0.0479 1 1
0.0064 1 0.5
0.0355 1 0.5
0.0085 1 0.5
0.0481 1 0.5
0.0657 0.2925 1
0.1512 0.2586 1
0.0349 0.363 0.5
0.0657 0.2925 1
0.0905 1 0.5
0.0341 1 0.5
0.0727 1 0.5
0.1947 1 0.5
0.0173 0.551 1
0.1739 1 0.5
0.0816 1 1
0.1818 1 0.5
0.1645 1 0.5
0.2031 0.2712 1
0.0192 0.3942 0.5
0.0153 1 0.5
0.0509 1 0.5
0.1194 1 0.5
0.0239 0.2732 0.5
0.1516 1 1
0.1766 0.4771 1
0.0262 1 0.5
0.2111 1 0.5
0.0042 0.2805 0.5
0.0384 1 0.5
0.2726 0.925 1
0.047 1 0.5
0.0192 0.6054 1
0.0365 0.2681 1
0.0479 0.3911 1
0.1298 1 0.5
0.4626 1 1
0.2711 1 1
0.0842 1 0.5
0.3046 1 1
0.0707 0.2822 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier ML1044 (Mycobacterium leprae), PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)
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