Detailed view for ML0521

Basic information

TDR Targets ID: 256456
Mycobacterium leprae, Probable cytoplasmic peptidase PepQ
Source Database / ID:  Leproma 

pI: 4.9306 | Length (AA): 376 | MW (Da): 39558 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00557   Metallopeptidase family M24
PF01321   Creatinase/Prolidase N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  
GO:0008235   metalloexopeptidase activity  
GO:0004177   aminopeptidase activity  
GO:0009987   cellular process  
GO:0006508   proteolysis  

Metabolic Pathways

Lysine degradation (KEGG)
Biotin metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 376 4s2r (P) 178 569 28.00 0 1 1.1544 0.76
4 133 5e2c (A) 4 133 78.00 0 1 1.40294 -1.97
5 376 3q6d (A) 2 353 41.00 0 1 1.45376 -0.34

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126673)

Species Accession Gene Product
Arabidopsis thaliana AT4G29490   metallopeptidase M24 family protein
Arabidopsis thaliana AT1G09300   Metallopeptidase M24 family protein
Brugia malayi Bm1_08285   Aminopeptidase P, N-terminal domain containing protein
Brugia malayi Bm1_41780   metallopeptidase family M24 containing protein
Candida albicans CaO19.7987   aminopeptidase
Candida albicans CaO19.354   aminopeptidase
Candida albicans CaO19.7263   potential metallopeptidase, similar to S. cerevisiae YFR006W
Caenorhabditis elegans CELE_R119.4   Protein PQN-59
Caenorhabditis elegans CELE_K12C11.1   Protein K12C11.1
Caenorhabditis elegans CELE_R119.2   Protein R119.2
Chlamydia trachomatis CT_574   aminopeptidase P
Dictyostelium discoideum DDB_G0282075   Xaa-Pro aminopeptidase 3
Dictyostelium discoideum DDB_G0269382   peptidase D
Drosophila melanogaster Dmel_CG9581   CG9581 gene product from transcript CG9581-RA
Drosophila melanogaster Dmel_CG5663   Dipeptidase C
Escherichia coli b2908   proline aminopeptidase P II
Escherichia coli b2385   Xaa-Pro aminopeptidase
Echinococcus granulosus EgrG_000621300   xaa Pro dipeptidase
Echinococcus granulosus EgrG_000921400   xaa Pro dipeptidase
Echinococcus granulosus EgrG_001034400   Xaa Pro aminopeptidase 3
Entamoeba histolytica EHI_010070   Xaa-Pro dipeptidase, putative
Entamoeba histolytica EHI_140630   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000921400   xaa Pro dipeptidase
Echinococcus multilocularis EmuJ_000621300   xaa Pro dipeptidase
Echinococcus multilocularis EmuJ_001034400   Xaa Pro aminopeptidase 3
Giardia lamblia GL50803_17327   Xaa-Pro dipeptidase
Homo sapiens ENSG00000196236   X-prolyl aminopeptidase (aminopeptidase P) 3, putative
Homo sapiens ENSG00000124299   peptidase D
Leishmania braziliensis LbrM.34.2300   aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24
Leishmania donovani LdBPK_352400.1   aminopeptidase P, putative
Leishmania infantum LinJ.35.2400   aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24
Leishmania major LmjF.35.2350   aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24
Leishmania mexicana LmxM.34.2350   aminopeptidase P, putative
Loa Loa (eye worm) LOAG_02414   hypothetical protein
Loa Loa (eye worm) LOAG_10174   hypothetical protein
Mycobacterium leprae ML0521   Probable cytoplasmic peptidase PepQ
Mus musculus ENSMUSG00000022401   X-prolyl aminopeptidase (aminopeptidase P) 3, putative
Mus musculus ENSMUSG00000063931   peptidase D
Mycobacterium tuberculosis Rv2535c   Probable cytoplasmic peptidase PepQ
Mycobacterium tuberculosis Rv2089c   Dipeptidase PepE
Mycobacterium ulcerans MUL_0331   dipeptidase
Mycobacterium ulcerans MUL_0330   aminopeptidase
Mycobacterium ulcerans MUL_2321   dipeptidase PepE
Mycobacterium ulcerans MUL_1764   cytoplasmic peptidase PepQ
Neospora caninum NCLIV_033100   prolidase, putative
Oryza sativa 4328771   Os02g0224400
Oryza sativa 4352534   Os12g0563500
Onchocerca volvulus OVOC9023   Dipeptidase C homolog
Saccharomyces cerevisiae YER078C   Icp55p
Saccharomyces cerevisiae YFR006W   putative Xaa-Pro dipeptidase
Schistosoma japonicum Sjp_0027920   ko:K01271 X-Pro dipeptidase [EC3.4.13.9], putative
Schistosoma mansoni Smp_090800   Xaa-Pro dipeptidase (M24 family)
Schmidtea mediterranea mk4.035850.00   Aminopeptidase P homologue
Schmidtea mediterranea mk4.019619.00   Dipeptidase C
Schmidtea mediterranea mk4.003379.02   Xaa-Pro dipeptidase
Trypanosoma brucei gambiense Tbg972.9.8450   aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24
Trypanosoma brucei Tb927.9.13490   metallo-peptidase, Clan MG, Family M24
Trypanosoma congolense TcIL3000_9_5720   metallo-peptidase, Clan MG, Family M24
Trypanosoma cruzi TcCLB.510749.99   aminopeptidase P, putative
Trypanosoma cruzi TcCLB.510751.4   aminopeptidase P, putative
Trypanosoma cruzi TcCLB.510655.120   metallo-peptidase, Clan MG, Family M24, putative
Toxoplasma gondii TGME49_233310   peptidase D, putative
Trichomonas vaginalis TVAG_255940   Clan MG, familly M24, aminopeptidase P-like metallopeptidase
Trichomonas vaginalis TVAG_013490   Clan MG, familly M24, aminopeptidase P-like metallopeptidase
Trichomonas vaginalis TVAG_040850   Clan MG, familly M24, aminopeptidase P-like metallopeptidase
Trichomonas vaginalis TVAG_321430   Clan MG, familly M24, aminopeptidase P-like metallopeptidase
Trichomonas vaginalis TVAG_403460   Clan MG, familly M24, aminopeptidase P-like metallopeptidase
Trichomonas vaginalis TVAG_386080   Clan MG, familly M24, aminopeptidase P-like metallopeptidase
Trichomonas vaginalis TVAG_227590   Clan MG, familly M24, aminopeptidase P-like metallopeptidase
Trichomonas vaginalis TVAG_437930   Clan MG, familly M24, aminopeptidase P-like metallopeptidase

Essentiality

ML0521 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2122 Mycobacterium tuberculosis non-essential nmpdr
Tb09.211.4330 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.4330 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.4330 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.4330 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b2385 Escherichia coli non-essential goodall
b2908 Escherichia coli non-essential goodall
CELE_R119.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_R119.4 Caenorhabditis elegans larval arrest wormbase
CELE_R119.4 Caenorhabditis elegans larval lethal wormbase
CELE_K12C11.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_K12C11.1 Caenorhabditis elegans larval arrest wormbase
TGME49_233310 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens peptidase D Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0113 0.258 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier ML0521 (Mycobacterium leprae), Probable cytoplasmic peptidase PepQ
Title for this comment
Comment