Detailed view for ML1514c

Basic information

TDR Targets ID: 256752
Mycobacterium leprae, PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase)
Source Database / ID:  Leproma 

pI: 6.9679 | Length (AA): 254 | MW (Da): 27935 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02511   Thymidylate synthase complementing protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0050797   thymidylate synthase (FAD) activity  
GO:0050660   FAD binding  
GO:0006231   dTMP biosynthetic process  

Metabolic Pathways

Pyrimidine metabolism (KEGG)
One carbon pool by folate (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 251 3gwc (A) 2 247 83.00 0 1 1.95115 -0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 2AF6:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2GQ2:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3GWC:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3HZG:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136913)

Species Accession Gene Product
Mycobacterium leprae ML1514c   PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase)
Mycobacterium tuberculosis Rv2754c   Probable thymidylate synthase ThyX (ts) (TSase)
Mycobacterium ulcerans MUL_2183   FAD-dependent thymidylate synthase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium tuberculosis Probable thymidylate synthase ThyX (ts) (TSase) Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Paramecium bursaria Chlorella virus 1 Probable thymidylate synthase 216 aa 27.1% 188 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1643 0.337 0.3568
0.2896 0.4165 1
0.1144 0.3181 0.6848
0.1177 0.669 0.9531
0.1151 0.4157 0
0.631 0.842 0.8703
0.4473 0.6845 1
0.7099 0.8659 1
0.1569 0.6097 0.6093
0.1129 0.3158 1
0.1577 0.4611 0.4611
0.0756 0.314 0.5
0.2896 0.4165 1
0.2309 0.7533 1
0.4622 0.8075 0.8418
0.189 0.7263 0.7263
0.3455 0.2762 0.9825
0.1877 0.6086 0.6056
0.1218 0.6 0.7418
0.2896 0.4165 1
0.3189 0.5088 0.4947
0.1598 0.4624 0.4604
0.1755 0.3017 0
0.0598 0.311 0.9067
0.1144 0.639 0.6354
0.1814 0.6542 0
0.0604 0.2642 0.5411
0.631 0.842 0.8703
0.1592 0.509 0.5064
0.179 0.5144 0.8822
0.4474 0.449 1
0.1569 0.6097 0.6093
0.0829 0.2971 0.5
0.4108 0.8012 0.8418
0.1946 0.9108 1
0.1717 0.4259 0
0.2532 0.2652 0.3367
0.1283 0.4146 0.4104
0.1569 0.6097 0.6093
0.3455 0.2763 0.9825
0.179 0.3197 0.3286
0.1133 0.6875 0.6853
0.3594 0.5657 0.8243
0.1303 0.9524 0.9504
0.4763 0.5904 0.6091
0.1283 0.4146 0.4104
0.215872 1 1
0.4846 0.5363 0.5519
0.3455 0.2762 0.9825
0.1877 0.6086 0.6056
0.107 0.6384 0.6354
0.2896 0.4165 1
0.7099 0.8659 1
0.0279 0.3129 0.5
0.3634 0.337 0.337
0.0598 0.311 0.9067
0.1577 0.3699 0.3594
1.0715 0.9793 1
0.976 0.9793 1
0.1755 0.3017 0
0.1336 0.4096 0
0.3177 0.4025 0.4082
0.1758 0.4105 0.4105
0.352 0.5873 1
0.5019 0.5254 0.5469
0.1632 0.3953 0.4084
0.1877 0.6086 0.6056
0.352 0.5873 1
0.2309 0.7533 1
0.1802 0.777 0
0.1235 0.669 0.9531
0.1626 0.2973 1
0.4398 0.3335 1
0.1587 0.3549 0.3743
0.5137 0.8076 0.8419
0.1303 0.8406 0.8379
0.4036 0.3063 0.8005
0.4036 0.3063 0.8005
0.1787 0.9088 1
0.1303 0.7457 0.7418
0.3634 0.337 0.337
0.4398 0.3335 1
0.1235 0.669 0.9531
0.1717 0.4261 0.4258
0.4917 0.5171 0.5372
0.1626 0.2973 1
0.2896 0.4165 1
0.1801 0.3133 0.2902
0.1686 0.2939 0.2995
0.1598 0.4624 0.4604
0.1698 0.4102 0.4023
0.108 0.6412 0.6409
0.7099 0.8659 1
0.1643 0.337 0.3568
0.1303 0.9524 0.9504
0.5019 0.5254 0.5469
0.2896 0.4165 1
1.1302 0.9793 1
0.1958 0.2519 1
0.1598 0.4624 0.4604
0.1136 0.3084 0.5
0.4824 0.5243 0.5388
0.179 0.5144 0.8822
0.631 0.842 0.8703
0.1877 0.6086 0.6056
0.1181 0.2877 0.5
0.5723 0.6707 0.8703
0.1946 0.9108 1
0.1065 0.4311 1
0.1218 0.6863 0.683
0.1686 0.286 0.291
0.3177 0.4025 0.4082
0.1569 0.2502 0.2583
0.961127 1 1
0.1239 0.7457 0.7418
0.4822 0.5901 0.6059
0.5723 0.6707 0.8703
0.7099 0.8659 1
0.5209 0.8076 0.8419
0.1643 0.337 0.3568
0.1755 0.3017 0
0.1679 0.5908 0.588
0.1835 0.3186 0.3324
0.5209 0.8076 0.8419
0.7664 0.97 1
0.5283 0.8075 0.8417
0.0533 0.306 1
0.0802 0.3007 0.5
0.1336 0.4096 0
0.6659 0.5915 1
0.1065 0.4311 1
0.3634 0.337 0.337
0.1598 0.4624 0.4604
0.3557 0.719 1
0.1717 0.4261 0.4258
0.1303 0.9524 0.9504
0.1144 0.3181 0.6848
0.6282 0.5299 1
0.5019 0.5254 0.5469
0.1766 0.9569 0.9569
0.1031 0.5119 0.9531
0.7099 0.5915 1
0.1181 0.3145 0.5
0.1946 0.4385 0.4385
0.1877 0.6038 0.6038
0.1717 0.4261 0.4258
0.4474 0.449 1
0.1667 0.3641 0.3814
0.1577 0.4611 0.4611
0.4036 0.3063 0.8005
0.1577 0.3699 0.3594
0.1755 0.3017 0
0.1851 0.7648 0.7648

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier ML1514c (Mycobacterium leprae), PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase)
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