pI: 4.6084 |
Length (AA): 330 |
MW (Da): 35335 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 330 | 3lmd (A) | 24 | 350 | 51.00 | 0 | 1 | 1.65264 | -1.37 |
254 | 329 | 5cwk (A) | 2 | 85 | 24.00 | 0.18 | 0.96 | 0.570703 | -1.43 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126937)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G17050 | solanesyl diphosphate synthase 2 |
Arabidopsis thaliana | AT1G78510 | solanesyl diphosphate synthase 1 |
Arabidopsis thaliana | AT2G34630 | geranyl diphosphate synthase 1 |
Babesia bovis | BBOV_IV007310 | polyprenyl synthetase superfamily protein |
Brugia malayi | Bm1_35720 | Polyprenyl synthetase family protein |
Candida albicans | CaO19.7478 | trans-hexaprenyltranstransferase |
Caenorhabditis elegans | CELE_C24A11.9 | Protein COQ-1 |
Cryptosporidium hominis | Chro.70416 | hypothetical protein |
Cryptosporidium parvum | cgd7_3730 | long chain fatty acyl diphosphate synthase |
Dictyostelium discoideum | DDB_G0280293 | hexaprenyl pyrophosphate synthetase |
Drosophila melanogaster | Dmel_CG31005 | CG31005 gene product from transcript CG31005-RA |
Escherichia coli | b3187 | octaprenyl diphosphate synthase |
Echinococcus granulosus | EgrG_000256100 | decaprenyl diphosphate synthase subunit 1 |
Entamoeba histolytica | EHI_028880 | geranylgeranyl pyrophosphate synthetase, putative |
Entamoeba histolytica | EHI_105060 | geranylgeranyl pyrophosphate synthase, putative |
Echinococcus multilocularis | EmuJ_000256100 | decaprenyl diphosphate synthase subunit 1 |
Homo sapiens | ENSG00000148459 | prenyl (decaprenyl) diphosphate synthase, subunit 1 |
Leishmania braziliensis | LbrM.15.1060 | solanesyl-diphosphate synthase, putative |
Leishmania donovani | LdBPK_151080.1 | solanesyl-diphosphate synthase, putative |
Leishmania infantum | LinJ.15.1080 | solanesyl-diphosphate synthase, putative |
Leishmania major | LmjF.15.1020 | solanesyl-diphosphate synthase, putative |
Leishmania mexicana | LmxM.15.1020 | farnesyl synthetase, putative |
Loa Loa (eye worm) | LOAG_00347 | polyprenyl synthetase |
Mycobacterium leprae | ML2277 | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) |
Mus musculus | ENSMUSG00000026784 | prenyl (solanesyl) diphosphate synthase, subunit 1 |
Mycobacterium tuberculosis | Rv0562 | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase) |
Mycobacterium ulcerans | MUL_0664 | polyprenyl diphosphate synthetase, GrcC1 |
Neospora caninum | NCLIV_036980 | hypothetical protein |
Oryza sativa | 9272514 | Os08g0193100 |
Oryza sativa | 4351957 | Os12g0271700 |
Oryza sativa | 4341844 | Os06g0678200 |
Plasmodium berghei | PBANKA_0300800 | octaprenyl pyrophosphate synthase, putative |
Plasmodium falciparum | PF3D7_0202700 | octaprenyl pyrophosphate synthase |
Plasmodium knowlesi | PKNH_0418400 | octaprenyl pyrophosphate synthase, putative |
Plasmodium vivax | PVX_003575 | octaprenyl pyrophosphate synthase, putative |
Plasmodium yoelii | PY00446 | Polyprenyl synthetase, putative |
Saccharomyces cerevisiae | YBR003W | trans-hexaprenyltranstransferase |
Schistosoma japonicum | Sjp_0306360 | Decaprenyl-diphosphate synthase subunit 1, putative |
Schistosoma japonicum | Sjp_0071520 | ko:K00810 similar to prenyl diphosphate synthase, subunit 1 [EC:2.5.1.-], putative |
Schistosoma mansoni | Smp_059800 | trans-prenyltransferase |
Schmidtea mediterranea | mk4.001177.03 | |
Schmidtea mediterranea | mk4.001177.02 | Prenyl transferase |
Trypanosoma brucei gambiense | Tbg972.9.3090 | farnesyl pyrophosphate synthetase, putative |
Trypanosoma brucei | Tb927.9.5890 | solanesyl-diphosphate synthase, putative |
Trypanosoma cruzi | TcCLB.509445.30 | solanesyl-diphosphate synthase |
Trypanosoma cruzi | TcCLB.427091.10 | solanesyl-diphosphate synthase, putative |
Trypanosoma cruzi | TcCLB.422031.10 | solanesyl-diphosphate synthase, putative |
Toxoplasma gondii | TGME49_269430 | polyprenyl synthetase superfamily protein |
Theileria parva | TP03_0238 | prenyl transferase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0532 | geranylgeranyl pyrophosphate synthase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.4300 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.4300 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.4300 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.4300 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3187 | Escherichia coli | essential | goodall |
CELE_C24A11.9 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_0300800 | Plasmodium berghei | Essential | plasmo |
TGME49_269430 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | Compounds | References |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | Compounds | References |
Trypanosoma cruzi | solanesyl-diphosphate synthase | Compounds | References |