Detailed view for ML0190c

Basic information

TDR Targets ID: 257123
Mycobacterium leprae, Conserved hypothetical protein
Source Database / ID:  Leproma 

pI: 7.4163 | Length (AA): 205 | MW (Da): 22988 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13532   2OG-Fe(II) oxygenase superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0035552   GO:oxidative single-stranded DNA demethylation  

GO:0016706   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors  
GO:0006307   DNA dealkylation  
GO:0051213   dioxygenase activity  
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  
GO:0006281   DNA repair  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 200 2iuw (A) 70 275 30.00 0 1 1.25842 -0.48
43 200 3s57 (A) 80 254 38.00 0 1 1.10683 -0.37
44 200 2iuw (A) 105 275 38.00 0 1 1.12895 -0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134523)

Species Accession Gene Product
Arabidopsis thaliana AT2G22260   DNA repair protein ALKBH2
Homo sapiens ENSG00000166199   alkB, alkylation repair homolog 3 (E. coli)
Mycobacterium leprae ML0190c   Conserved hypothetical protein
Mus musculus ENSMUSG00000040174   alkB, alkylation repair homolog 3 (E. coli)
Mycobacterium tuberculosis Rv1000c   Conserved hypothetical protein
Mycobacterium ulcerans MUL_4665   hypothetical protein
Schmidtea mediterranea mk4.002216.04   Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Schmidtea mediterranea mk4.002240.00   Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Schmidtea mediterranea mk4.003125.06   Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Schmidtea mediterranea mk4.004714.01   Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens alkB, alkylation repair homolog 3 (E. coli) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0404 0.4318 1
0.0592 0.6478 1
0.0579 0.3847 1
0.0945 0.3861 0.5
0.019 0.545 0.5
0.0945 0.3861 0.5
0.0207 0.4117 1
0.074362 0.416335 1
0.0807 0.471 1
0.0945 0.3861 0.5
0.0411 0.3273 0.5
0.0796 0.4859 1
0.0411 0.3273 0.5
0.0188 0.2724 0
0.0195 0.5585 0.5
0.0194 0.3033 1
0.0431 0.3169 0.316
0.023 0.804 0.5
0.023 0.5679 1
0.0579 0.3847 1
0.0207 0.4117 1
0.0185 0.6037 0.5
0.0579 0.3847 1
0.0579 0.3847 1
0.0431 0.3169 0.316
0.0579 0.3847 1
0.023 0.732 0.5
0.0579 0.3847 1
0.0431 0.3169 0.316
0.023 0.3291 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier ML0190c (Mycobacterium leprae), Conserved hypothetical protein
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