pI: 7.138 |
Length (AA): 2017 |
MW (Da): 223400 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
11 | 171 | 5cwf (A) | 15 | 175 | 14.00 | 0 | 0.03 | 0.298822 | -0.95 |
439 | 1775 | 5exr (C) | 343 | 1408 | 41.00 | 0 | 1 | 0.629166 | 1.22 |
1096 | 1415 | 1d5a (A) | 373 | 654 | 34.00 | 0 | 1 | 0.356951 | 0.7 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Hehl AB Fritz HM Sibley/Greg |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Ortholog group members (OG5_128177)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G67100 | DNA polymerase alpha catalytic subunit |
Babesia bovis | BBOV_IV007060 | DNA polymerase alpha subunit, putative |
Brugia malayi | Bm1_48460 | DNA polymerase alpha catalytic subunit |
Candida albicans | CaO19.5873 | likely DNA polymerase I alpha subunit p180 |
Candida albicans | CaO19.13294 | likely DNA polymerase I alpha subunit p180 |
Caenorhabditis elegans | CELE_Y47D3A.29 | Protein Y47D3A.29, isoform B |
Cryptosporidium hominis | Chro.30484 | DNA polymerase alpha, DNAPol alpha |
Cryptosporidium parvum | cgd3_4290 | DNA polymerase alpha catalytic subunit |
Dictyostelium discoideum | DDB_G0282191 | DNA polymerase alpha catalytic subunit |
Drosophila melanogaster | Dmel_CG6349 | DNA polymerase alpha 180kD |
Echinococcus granulosus | EgrG_000475300 | DNA polymerase alpha catalytic subunit |
Entamoeba histolytica | EHI_151520 | DNA polymerase alpha catalytic subunit, putative |
Echinococcus multilocularis | EmuJ_000475300 | DNA polymerase alpha catalytic subunit |
Giardia lamblia | GL50803_27326 | DNA polymerase alpha subunit A |
Homo sapiens | ENSG00000101868 | polymerase (DNA directed), alpha 1, catalytic subunit |
Leishmania braziliensis | LbrM.16.1600 | DNA polymerase I alpha catalytic subunit, putative |
Leishmania donovani | LdBPK_161640.1 | DNA polymerase I alpha catalytic subunit, putative |
Leishmania infantum | LinJ.16.1640 | DNA polymerase I alpha catalytic subunit, putative |
Leishmania major | LmjF.16.1540 | DNA polymerase I alpha catalytic subunit, putative |
Leishmania mexicana | LmxM.16.1540 | DNA polymerase I alpha catalytic subunit, putative |
Loa Loa (eye worm) | LOAG_01730 | hypothetical protein |
Mus musculus | ENSMUSG00000006678 | polymerase (DNA directed), alpha 1 |
Neospora caninum | NCLIV_062650 | DNA polymerase alpha catalytic subunit, putative |
Oryza sativa | 4325052 | Os01g0868300 |
Onchocerca volvulus | OVOC1050 | DNA polymerase alpha catalytic subunit homolog |
Plasmodium berghei | PBANKA_0613200 | DNA polymerase alpha catalytic subunit A, putative |
Plasmodium falciparum | PF3D7_0411900 | DNA polymerase alpha catalytic subunit A |
Plasmodium knowlesi | PKNH_0310100 | DNA polymerase alpha catalytic subunit A, putative |
Plasmodium vivax | PVX_000650 | DNA polymerase alpha, putative |
Plasmodium yoelii | PY06115 | DNA polymerase alpha-related |
Saccharomyces cerevisiae | YNL102W | DNA-directed DNA polymerase alpha catalytic subunit POL1 |
Schistosoma japonicum | Sjp_0041180 | ko:K02320 DNA polymerase alpha subunit A, putative |
Schistosoma mansoni | Smp_178260 | DNA polymerase alpha catalytic subunit |
Schmidtea mediterranea | mk4.003330.10 | DNA polymerase alpha catalytic subunit |
Schmidtea mediterranea | mk4.006149.00 | |
Schmidtea mediterranea | mk4.000561.18 | |
Schmidtea mediterranea | mk4.002208.05 | DNA polymerase alpha catalytic subunit |
Schmidtea mediterranea | mk4.003330.09 | DNA polymerase alpha catalytic subunit |
Schmidtea mediterranea | mk4.002208.06 | DNA polymerase alpha catalytic subunit |
Schmidtea mediterranea | mk4.035062.00 | DNA polymerase alpha catalytic subunit |
Trypanosoma brucei gambiense | Tbg972.8.4690 | DNA polymerase alpha catalytic subunit,DNA polymerase I, putative |
Trypanosoma brucei | Tb927.8.4880 | DNA polymerase alpha catalytic subunit |
Trypanosoma congolense | TcIL3000_0_02350 | DNA polymerase alpha catalytic subunit |
Trypanosoma cruzi | TcCLB.508837.180 | DNA polymerase I alpha catalytic subunit, putative |
Toxoplasma gondii | TGME49_217910 | DNA polymerase (pol2) superfamily protein |
Theileria parva | TP03_0202 | DNA polymerase alpha, putative |
Trichomonas vaginalis | TVAG_342390 | DNA polymerase alpha catalytic subunit, putative |
Trichomonas vaginalis | TVAG_198840 | DNA polymerase II, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.4880 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.4880 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.4880 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.4880 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y47D3A.29 | Caenorhabditis elegans | embryonic lethal | wormbase |
YNL102W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_217910 this record | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), alpha 1, catalytic subunit | Compounds | References |