Detailed view for LmjF.29.0370

Basic information

TDR Targets ID: 25849
Leishmania major, protein kinase-like protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.233 | Length (AA): 1388 | MW (Da): 147126 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
482 889 1o6l (A) 150 468 24.00 0 1 0.16 0.31
739 851 2bva (A) 472 575 32.00 0.000083 0.66 0.43 -0.75
297 336 3n9x (A) 22 61 48.00 0.73 0.48 0.485818 0.38
476 1014 3hx4 (A) 43 480 21.00 0 1 0.105629 1.33
515 627 1wak (A) 109 222 31.00 0.026 0.69 0.180412 1.07
743 848 5f9e (A) 541 635 41.00 0.000000066 0.23 0.180369 0.46
743 844 3be2 (A) 1048 1159 33.00 0.14 0.53 0.339487 -0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_183796)

Species Accession Gene Product
Leishmania braziliensis LbrM.29.0310   protein kinase-like protein
Leishmania donovani LdBPK_290380.1   protein kinase-like protein
Leishmania infantum LinJ.29.0380   protein kinase-like protein
Leishmania major LmjF.29.0370   protein kinase-like protein
Leishmania mexicana LmxM.08_29.0370   protein kinase-like protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.7

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 27.6% 152 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0063 1 1
0.0007 0.5 0.5
0.0063 0.7244 0.2543
0.0092 1 0.5
0.0039 0.5 0.5
0.0033 0.5 0.5
0.0008 0.5 0.5
0.0011 1 0.5
0.0066 0.3101 0
0.0042 0.5 0.5
0.0032 0.5 0.5
0.0061 0.6883 0.5304
0.0064 0.3377 0
0.0036 0.5 0.5
0.0003 0.5 0.5
0.0059 1 1
0.0004 0.5 0.5
0.0032 0.5 0.5
0.0033 1 1
0.0062 0.6935 0
0.0039 0.9485 0.5
0.0007 0.5 0.5
0.0059 1 1
0.0012 0.5 0.5
0.0091 1 0.5
0.0067 0.5 0.5
0.0081 0.5 0.5
0.0016 0.5 0.5
0.0027 1 0.5
0.0088 0.4477 1
0.0059 1 1
0.0081 1 0.5
0.0018 0.5 0.5
0.0012 0.5 0.5
0.0093 0.8828 0
0.0022 0.5 0.5
0.0037 1 0.5
0.0039 0.5 0.5
0.0029 0.5 0.5
0.0026 0.5 0.5
0.0056 1 0.5
0.0069 0.3067 1
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0098 0.3242 0.2614

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.29.0370 (Leishmania major), protein kinase-like protein
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