pI: 10.984 |
Length (AA): 127 |
MW (Da): 14254 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
30 | 78 | 4pjo (K) | 9 | 59 | 37.00 | 0.83 | 0.15 | 0.440627 | 2.42 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | ME49 merozoite. | Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | VEG Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | ME49 Tachyzoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Fritz HM Sibley/Greg |
Gregory | ToxoDB |
Sibley/Greg | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Ortholog group members (OG5_129752)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G05090 | protein lateral root stimulator 1 |
Brugia malayi | Bm1_41555 | Hypothetical WD-repeat protein F35G12.4 in chromosome III |
Candida albicans | CaO19.12379 | six potential WD domain G-beta repeats |
Candida albicans | CaO19.4913 | six potential WD domain G-beta repeats |
Caenorhabditis elegans | CELE_F35G12.4 | Protein F35G12.4, isoform C |
Dictyostelium discoideum | DDB_G0277533 | WD40 repeat-containing protein |
Drosophila melanogaster | Dmel_CG9062 | CG9062 gene product from transcript CG9062-RC |
Echinococcus granulosus | EgrG_000043100 | WD repeat containing protein 48 |
Echinococcus multilocularis | EmuJ_000043100 | WD repeat containing protein 48 |
Homo sapiens | ENSG00000114742 | WD repeat domain 48 |
Loa Loa (eye worm) | LOAG_11473 | hypothetical protein |
Mus musculus | ENSMUSG00000032512 | WD repeat domain 48 |
Oryza sativa | 4351590 | Os12g0165000 |
Schistosoma japonicum | Sjp_0078920 | WD repeat-containing protein 48, putative |
Schistosoma mansoni | Smp_194110 | hypothetical protein |
Schmidtea mediterranea | mk4.007216.00 | |
Schmidtea mediterranea | mk4.007216.01 | |
Toxoplasma gondii | TGME49_253180 | hypothetical protein |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | WD repeat domain 48 | Compounds | References |