pI: 7.0239 |
Length (AA): 303 |
MW (Da): 33735 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
25 | 296 | 3d3w (A) | 1 | 237 | 19.00 | 0 | 1 | 0.99259 | 0.06 |
29 | 298 | 4xwy (A) | 2 | 257 | 28.00 | 0 | 1 | 1.16099 | -0.09 |
30 | 291 | 1zem (A) | 6 | 254 | 18.00 | 0 | 0.98 | 0.967586 | -0.34 |
33 | 250 | 1ja9 (A) | 31 | 218 | 31.00 | 0.15 | 0.92 | 0.874072 | 0.4 |
34 | 222 | 2a4k (A) | 9 | 167 | 35.00 | 0.13 | 0.87 | 0.748362 | 0.75 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | ME49 Bradyzoite. | Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 Oocyst. | Gregory Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 merozoite. | Hehl AB |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_131569)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_29970 | oxidoreductase, short chain dehydrogenase/reductase family protein |
Dictyostelium discoideum | DDB_G0290009 | sepiapterin reductase |
Drosophila melanogaster | Dmel_CG12117 | Sepiapterin reductase |
Echinococcus granulosus | EgrG_001041150 | hypothetical protein |
Echinococcus multilocularis | EmuJ_001041150 | conserved hypothetical protein |
Homo sapiens | ENSG00000116096 | sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) |
Loa Loa (eye worm) | LOAG_07137 | oxidoreductase |
Mus musculus | ENSMUSG00000033735 | sepiapterin reductase |
Neospora caninum | NCLIV_031930 | sepiapterin reductase, putative |
Onchocerca volvulus | OVOC8233 | Sepiapterin reductase homolog |
Schmidtea mediterranea | mk4.000668.03 | Sepiapterin reductase |
Toxoplasma gondii | TGME49_231920 | oxidoreductase, short chain dehydrogenase/reductase family protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_231920 this record | Toxoplasma gondii | Probably non-essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Macaca mulatta | Hydroxysteroid 11-beta dehydrogenase 1 | 140 aa | 26.2% | 160 aa | Compounds | References |