Detailed view for TGME49_243710

Basic information

TDR Targets ID: 259021
Toxoplasma gondii, t-complex protein beta subunit
Source Database / ID:  ToxoDB 

pI: 5.7242 | Length (AA): 568 | MW (Da): 61473 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00118   TCP-1/cpn60 chaperonin family

Gene Ontology

Mouse over links to read term descriptions.
GO:0051082   unfolded protein binding  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0044267   cellular protein metabolic process  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 561 4b2t (B) 10 524 57.00 0 1 1.45169 0.31
219 369 1e0r (B) 215 365 26.00 0 1 0.661045 -0.79

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Bradyzoite. Gregory Hehl AB Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile ME49 Oocyst. Fritz HM
Show/Hide expression data references
  • Gregory ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Sibley/Greg ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.

Orthologs

Ortholog group members (OG5_127730)

Species Accession Gene Product
Arabidopsis thaliana AT5G20890   TCP-1/cpn60 chaperonin family protein
Babesia bovis BBOV_III000880   T-complex protein beta subunit, putative
Brugia malayi Bm1_10270   T-complex protein 1, beta subunit
Brugia malayi Bm1_28565   T-complex protein 1, beta subunit
Candida albicans CaO19.1402   similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol
Candida albicans CaO19.8980   similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol
Caenorhabditis elegans CELE_T21B10.7   Protein CCT-2
Cryptosporidium hominis Chro.60586   TCP-1/cpn60 chaperonin-related protein
Cryptosporidium parvum cgd6_5080   GroEL-like chaperone (ATpase); T-complex protein 1
Dictyostelium discoideum DDB_G0291358   chaperonin containing TCP1 beta subunit
Drosophila melanogaster Dmel_CG7033   CG7033 gene product from transcript CG7033-RA
Echinococcus granulosus EgrG_000702700   chaperonin containing TCP1 subunit 2 beta
Entamoeba histolytica EHI_103270   T-complex protein 1 beta subunit, putative
Echinococcus multilocularis EmuJ_000702700   chaperonin containing TCP1, subunit 2 (beta)
Giardia lamblia GL50803_11397   TCP-1 chaperonin subunit beta
Homo sapiens ENSG00000166226   chaperonin containing TCP1, subunit 2 (beta)
Leishmania braziliensis LbrM.27.1370   T-complex protein 1, beta subunit, putative
Leishmania donovani LdBPK_271150.1   T-complex protein 1, beta subunit, putative
Leishmania infantum LinJ.27.1150   T-complex protein 1, beta subunit, putative
Leishmania major LmjF.27.1260   T-complex protein 1, beta subunit, putative
Leishmania mexicana LmxM.27.1260   T-complex protein 1, beta subunit, putative
Loa Loa (eye worm) LOAG_01393   T-complex protein 1
Mus musculus ENSMUSG00000034024   chaperonin containing Tcp1, subunit 2 (beta)
Neospora caninum NCLIV_018400   TCP-1/cpn60 family chaperonin, putative
Oryza sativa 4339570   Os05g0556700
Oryza sativa 4333462   Os03g0619400
Plasmodium berghei PBANKA_0405200   T-complex protein 1 subunit beta, putative
Plasmodium falciparum PF3D7_0306800   T-complex protein 1 subunit beta
Plasmodium knowlesi PKNH_0835900   T-complex protein 1 subunit beta, putative
Plasmodium vivax PVX_119465   T-complex protein 1 subunit beta, putative
Plasmodium yoelii PY06837   putative T-complex protein beta subunit
Saccharomyces cerevisiae YIL142W   Cct2p
Schistosoma japonicum Sjp_0301360   ko:K09494 T-complex protein 1 subunit beta, putative
Schistosoma mansoni Smp_054340.3   chaperonin containing t-complex protein 1 beta subunit tcpb
Schistosoma mansoni Smp_054340.2   chaperonin containing t-complex protein 1 beta subunit tcpb
Schistosoma mansoni Smp_054340.1   chaperonin containing t-complex protein 1 beta subunit tcpb
Schmidtea mediterranea mk4.001712.05   T-complex protein 1 subunit beta
Trypanosoma brucei gambiense Tbg972.11.2030   T-complex protein 1, beta subunit, putative
Trypanosoma brucei Tb927.11.1900   T-complex protein 1, beta subunit, putative
Trypanosoma cruzi TcCLB.508357.90   T-complex protein 1, beta subunit, putative
Toxoplasma gondii TGME49_243710   t-complex protein beta subunit
Theileria parva TP03_0723   T-complex protein 1, beta subunit, putative
Trichomonas vaginalis TVAG_177930   chaperonin-60kD, ch60, putative
Trichomonas vaginalis TVAG_178890   chaperonin, putative

Essentiality

TGME49_243710 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
CELE_T21B10.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_T21B10.7 Caenorhabditis elegans larval arrest wormbase
CELE_T21B10.7 Caenorhabditis elegans slow growth wormbase
CELE_T21B10.7 Caenorhabditis elegans sterile wormbase
YIL142W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0405200 Plasmodium berghei Essential plasmo
TGME49_243710 this record Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Macaaca fascicularis T-complex protein 1 subunit beta Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0029 0.3959 0.4364
0.0029 0.8089 1
0.0024 0.7795 0
0.0029 1 0.5
0.0029 0.5081 0.5
0.0029 0.8021 0.5
0.0025 0.5081 0.5
0.0025 0.4859 1
0.0026 1 1
0.0025 0.5081 0.5
0.0024 0.7795 0
0.0029 0.8089 1
0.0024 0.8021 0
0.0024 0.5081 0.5
0.0029 0.5081 0.5
0.0024 0.2863 0.5
0.0028 0.5425 1
0.0029 0.5081 0.5
0.0028 0.5081 0.5
0.0029 0.3537 0
0.0029 0.5 0.5
0.0024 1 1
0.0029 0.5081 0.5
0.0026 0.382 0.4274
0.0029 1 1
0.0029 1 0.5
0.0028 0.4849 1
0.0029 1 0.5
0.0025 1 1
0.0027 0.5 0.5
0.0029 0.4583 1
0.0029 0.3636 0.3636
0.0029 0.8881 0
0.0024 0.5701 0.5
0.0029 0.6524 0.4364
0.0029 0.8021 0.5
0.0025 0.3824 0.5913
0.0029 0.2586 0
0.0024 1 1
0.0029 0.5 0.5
0.0029 0.467 0.5
0.0025 1 1
0.0029 1 1
0.0025 1 1
0.0024 0.4057 1
0.0024 0.5081 0.5
0.0023 0.515 0
0.0029 0.4866 1
0.0025 0.5 0.5
0.0024 0.3409 0.3409
0.0024 0.3015 0
0.0029 0.5081 0.5
0.0024 0.8021 0
0.0028 0.3636 0.3636
0.0025 0.2819 0
0.0028 0.5081 0.5
0.0025 0.9251 0
0.0029 0.5 0.5
0.0029 0.6065 0.5
0.0028 0.5081 0.5
0.0026 0.5 0.5
0.0025 0.3146 1
0.0029 1 0.5
0.0029 0.5081 0.5
0.0029 0.3548 0.5
0.0029 1 0.5
0.0029 0.8881 0
0.0024 0.8881 0
0.0029 0.8881 0
0.0029 0.5081 0.5
0.0029 0.4866 1
0.0027 0.2808 1
0.0029 0.8021 0.5
0.0028 1 0.5
0.0024 1 1
0.0029 1 1
0.0029 0.2824 1
0.0026 1 1
0.0029 0.2972 0.2415
0.0029 0.8881 0
0.0029 0.7331 0.7135
0.0029 0.3518 0.5
0.0023 0.3284 0
0.0025 0.2611 0
0.0029 0.8881 0
0.0028 0.8089 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TGME49_243710 (Toxoplasma gondii), t-complex protein beta subunit
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