pI: 6.9881 |
Length (AA): 3215 |
MW (Da): 349119 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 24 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
236 | 500 | 1o2d (A) | 4 | 288 | 13.00 | 0 | 0.33 | 0.07 | -0.41 |
325 | 698 | 1sg6 (A) | 102 | 392 | 39.00 | 0 | 1 | 0.2 | -0.06 |
723 | 1198 | 1rf6 (A) | 5 | 424 | 14.00 | 0 | 1 | 0.18 | 0.62 |
1220 | 1665 | 2aa9 (A) | 2 | 425 | 13.00 | 0 | 0.96 | 0 | 0.47 |
2932 | 3256 | 1npy (A) | 1 | 269 | 25.00 | 0 | 1 | -0.02 | 0.07 |
2937 | 3323 | 1gpj (A) | 46 | 374 | 15.00 | 0 | 0.95 | -0.26 | 0.67 |
2945 | 3249 | 1vi2 (A) | 10 | 282 | 21.00 | 0 | 1 | 0.27 | -0.23 |
227 | 698 | 3okf (A) | 5 | 361 | 27.00 | 0 | 1 | 0.0974118 | 0.85 |
321 | 697 | 3okf (A) | 92 | 360 | 37.00 | 0 | 1 | 0.0895628 | 0.6 |
327 | 663 | 5eks (A) | 93 | 322 | 44.00 | 0 | 1 | 0.0374212 | 1.2 |
526 | 697 | 4p53 (A) | 220 | 391 | 24.00 | 0 | 1 | 0.361799 | -0.32 |
718 | 1279 | 3nvs (A) | 2 | 423 | 21.00 | 0 | 1 | 0.0124056 | 1.18 |
727 | 1033 | 2aa9 (A) | 11 | 199 | 42.00 | 0.00000038 | 1 | -0.10091 | 0.89 |
733 | 1033 | 3ti2 (A) | 17 | 200 | 39.00 | 0.0093 | 1 | -0.125776 | 0.72 |
1233 | 1284 | 3nvs (A) | 237 | 288 | 44.00 | 0.00011 | 0.5 | 0.397774 | 1.01 |
1468 | 1668 | 3sg1 (A) | 233 | 414 | 13.00 | 0 | 0.57 | 0.117819 | -0.16 |
1486 | 1668 | 3slh (A) | 298 | 429 | 33.00 | 0 | 0.99 | -0.00877932 | 0.47 |
1530 | 1668 | 5buf (A) | 594 | 752 | 31.00 | 0.29 | 0.72 | 0.232835 | -0.05 |
1996 | 2118 | 1kag (A) | 26 | 162 | 20.00 | 0 | 0.66 | 0.227558 | -0.26 |
2383 | 2450 | 2ocz (A) | 20 | 87 | 32.00 | 0 | 0.46 | 0.474451 | -1.15 |
2389 | 2452 | 2egz (A) | 24 | 88 | 30.00 | 0 | 0.61 | 0.427207 | -1.22 |
2984 | 3135 | 1npy (A) | 47 | 265 | 32.00 | 0 | 0.92 | -0.0654216 | 0.27 |
2984 | 3128 | 3phh (A) | 48 | 253 | 30.00 | 0 | 1 | -0.0725989 | 0.4 |
2991 | 3050 | 3u62 (A) | 50 | 102 | 40.00 | 0.52 | 0.82 | 0.285263 | 0.78 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Fritz HM Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 merozoite. | Hehl AB |
Sibley/Greg | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Ortholog group members (OG5_127183)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G45300 | 3-phosphoshikimate 1-carboxyvinyltransferase / 5-enolpyruvylshikimate-3-phosphate / EPSP synthase |
Arabidopsis thaliana | AT1G48860 | putative 5-enolpyruvylshikimate-3-phosphate synthase |
Arabidopsis thaliana | AT5G66120 | putative 3-dehydroquinate synthase |
Candida albicans | CaO19.12175 | similar to S. cerevisiae ARO1 pentafunctional aromatic amino acid family biosynthesis protein |
Candida albicans | CaO19.4704 | similar to S. cerevisiae ARO1 pentafunctional aromatic amino acid family biosynthesis protein |
Chlamydia trachomatis | CT_366 | phosphoshikimate 1-carboxyl vinyltransferase |
Chlamydia trachomatis | CT_369 | dehyroquinate synthase |
Escherichia coli | b3389 | 3-dehydroquinate synthase |
Escherichia coli | b0908 | 5-enolpyruvylshikimate-3-phosphate synthetase |
Mycobacterium leprae | ML0792c | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS |
Mycobacterium leprae | ML0518 | 3-dehydroquinate synthase AroB |
Mycobacterium tuberculosis | Rv3227 | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) |
Mycobacterium tuberculosis | Rv2538c | 3-dehydroquinate synthase AroB |
Mycobacterium ulcerans | MUL_2560 | 3-phosphoshikimate 1-carboxyvinyltransferase |
Mycobacterium ulcerans | MUL_1761 | 3-dehydroquinate synthase |
Neospora caninum | NCLIV_053120 | 3-dehydroquinate synthase (EC 4.2.3.4), related |
Oryza sativa | 4347717 | Os09g0539100 |
Oryza sativa | 4340026 | Os06g0133900 |
Saccharomyces cerevisiae | YDR127W | pentafunctional protein ARO1p |
Schistosoma mansoni | Smp_109520 | 3-dehydroquinate synthase |
Schmidtea mediterranea | mk4.065648.00 | |
Toxoplasma gondii | TGME49_307040 | shikimate dehydrogenase substrate binding domain-containing protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2582 | Mycobacterium tuberculosis | essential | nmpdr |
b0908 | Escherichia coli | non-essential | goodall |
b3389 | Escherichia coli | non-essential | goodall |
TGME49_307040 this record | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Escherichia coli | 3-dehydroquinate synthase | Compounds | References |
Escherichia coli | 5-enolpyruvylshikimate-3-phosphate synthetase | Compounds | References |