pI: 5.9083 |
Length (AA): 266 |
MW (Da): 30266 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
12 | 262 | 4r17 (D) | 1 | 241 | 16.00 | 0.000000018 | 1 | 1.08091 | 0.22 |
28 | 253 | 5le5 (M) | 1 | 215 | 39.00 | 0 | 1 | 1.29182 | -0.32 |
36 | 240 | 1yar (H) | 1 | 188 | 19.00 | 0.016 | 1 | 1.01888 | -0.58 |
36 | 244 | 1ryp (L) | 1 | 194 | 21.00 | 0 | 1 | 1.05061 | -0.57 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_127562)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G56450 | 20S proteasome beta subunit G1 |
Babesia bovis | BBOV_IV002060 | proteasome subunit beta type 4 |
Brugia malayi | Bm1_48355 | Proteasome A-type and B-type family protein |
Candida albicans | CaO19.4230 | endopeptidase subunit of proteasome |
Candida albicans | CaO19.11705 | endopeptidase subunit of proteasome |
Caenorhabditis elegans | CELE_F39H11.5 | Protein PBS-7 |
Cryptosporidium hominis | Chro.50050 | beta tubulin |
Cryptosporidium parvum | cgd5_3220 | proteasome subunit beta7; NTN hydrolase fold |
Dictyostelium discoideum | DDB_G0273163 | 20S proteasome subunit beta-4 |
Dictyostelium discoideum | DDB_G0273909 | 20S proteasome subunit alpha-4 |
Drosophila melanogaster | Dmel_CG12000 | Proteasome beta7 subunit |
Echinococcus granulosus | EgrG_001150600 | proteasome prosome macropain subunit beta type |
Entamoeba histolytica | EHI_137970 | proteasome subunit beta Type 4 precursor, putative |
Echinococcus multilocularis | EmuJ_001150600 | proteasome (prosome macropain) subunit beta type |
Giardia lamblia | GL50803_1995 | Proteasome subunit beta type 4 precursor |
Homo sapiens | ENSG00000159377 | proteasome (prosome, macropain) subunit, beta type, 4 |
Leishmania braziliensis | LbrM.20.3950 | 20s proteasome beta 7 subunit, (putative) |
Leishmania braziliensis | LbrM.20.3980 | 20s proteasome beta 7 subunit, (putative) |
Leishmania infantum | LinJ.34.4280 | hypothetical protein, conserved |
Leishmania infantum | LinJ.34.4390 | 20s proteasome beta 7 subunit, (putative) |
Leishmania major | LmjF.34.4400 | 20s proteasome beta 7 subunit, (putative) |
Leishmania major | LmjF.34.4430 | 20s proteasome beta 7 subunit, (putative) |
Leishmania major | LmjF.34.4460 | 20s proteasome beta 7 subunit, (putative) |
Leishmania major | LmjF.34.4520 | proteasome beta 7 subunit, putative |
Leishmania major | LmjF.34.4370 | 20s proteasome beta 7 subunit, (putative) |
Leishmania major | LmjF.34.4340 | 20s proteasome beta 7 subunit, (putative) |
Leishmania major | LmjF.34.4490 | 20s proteasome beta 7 subunit, (putative) |
Leishmania mexicana | LmxM.33.4340 | 20s proteasome beta 7 subunit, (putative) |
Loa Loa (eye worm) | LOAG_09447 | proteasome A-type and B-type family protein |
Mus musculus | ENSMUSG00000005779 | proteasome (prosome, macropain) subunit, beta type 4 |
Neospora caninum | NCLIV_019480 | proteasome A-type and B-type domain-containing protein, putative |
Oryza sativa | 4347573 | Os09g0515200 |
Plasmodium berghei | PBANKA_1226500 | proteasome subunit beta type-4, putative |
Plasmodium falciparum | PF3D7_0803800 | proteasome subunit beta type-4 |
Plasmodium knowlesi | PKNH_0115100 | proteasome subunit beta type-4, putative |
Plasmodium vivax | PVX_093555 | proteasome subunit beta type-4, putative |
Plasmodium yoelii | PY00806 | proteasome beta-subunit |
Saccharomyces cerevisiae | YFR050C | proteasome core particle subunit beta 7 |
Schistosoma japonicum | Sjp_0068310 | ko:K02736 20S proteasome subunit beta 7, putative |
Schistosoma mansoni | Smp_056500 | proteasome subunit beta 4 (T01 family) |
Schmidtea mediterranea | mk4.000293.03 | Proteasome subunit beta type-4 |
Trypanosoma brucei gambiense | Tbg972.4.170 | proteasome beta 7 subunit, putative |
Trypanosoma brucei | Tb927.4.430 | proteasome beta 7 subunit |
Trypanosoma congolense | TcIL3000_4_120 | proteasome beta 7 subunit |
Trypanosoma cruzi | TcCLB.510689.30 | proteasome beta 7 subunit, putative |
Toxoplasma gondii | TGME49_280710 | 20S proteasome subunit beta 7, putative |
Theileria parva | TP03_0446 | 20S proteasome beta 7 subunit, putative |
Trichomonas vaginalis | TVAG_290960 | Family T1, proteasome beta subunit, threonine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.430 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.430 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.430 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.4.430 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F39H11.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F39H11.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F39H11.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F39H11.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F39H11.5 | Caenorhabditis elegans | sterile | wormbase |
YFR050C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1226500 | Plasmodium berghei | Slow | plasmo |
TGME49_280710 this record | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 4 | Compounds | References |