Detailed view for TGME49_224110

Basic information

TDR Targets ID: 261428
Toxoplasma gondii, adhesion regulating molecule region protein, putative

Source Database / ID:  ToxoDB 

pI: 4.5368 | Length (AA): 396 | MW (Da): 43126 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04683   Proteasome complex subunit Rpn13 ubiquitin receptor
PF16550   UCH-binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0005634   nucleus  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
83 387 2kr0 (A) 15 407 28.00 0 1 0.692902 0.22
92 243 2kr0 (A) 24 166 42.00 0 1 0.840838 -0.18
249 370 2mkz (A) 16 137 20.00 0 0.97 0.599581 -0.78

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile ME49 merozoite. Hehl AB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 Oocyst, ME49 Bradyzoite. Gregory Fritz HM Sibley/Greg
Show/Hide expression data references
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Gregory ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Sibley/Greg ToxoDB

Orthologs

Ortholog group members (OG5_128928)

Species Accession Gene Product
Arabidopsis thaliana AT2G26590   regulatory particle non-ATPase 13
Babesia bovis BBOV_III006190   conserved hypothetical protein
Brugia malayi Bm1_46000   Adhesion regulating molecule conserved region family protein
Candida albicans CaO19.8660   similar to S. cerevisiae RPN13 (YLR421C) subunit of the 19S regulatory particle of the 26S proteasome
Candida albicans CaO19.1058   similar to S. cerevisiae RPN13 (YLR421C) subunit of the 19S regulatory particle of the 26S proteasome
Caenorhabditis elegans CELE_C56G2.7   Protein C56G2.7
Dictyostelium discoideum DDB_G0272624   adhesion regulating molecule family protein
Dictyostelium discoideum DDB_G0274093   adhesion regulating molecule family protein
Drosophila melanogaster Dmel_CG13349   Regulatory particle non-ATPase 13
Drosophila melanogaster Dmel_CG6789   Regulatory particle non-ATPase 13-related
Echinococcus granulosus EgrG_000592000   adhesion regulating molecule 1
Echinococcus multilocularis EmuJ_000592000   adhesion regulating molecule 1
Homo sapiens ENSG00000130706   adhesion regulating molecule 1
Loa Loa (eye worm) LOAG_04044   hypothetical protein
Mus musculus ENSMUSG00000039041   adhesion regulating molecule 1
Neospora caninum NCLIV_048420   hypothetical protein
Oryza sativa 4339809   Os05g0594800
Onchocerca volvulus OVOC8619   Proteasomal ubiquitin receptor ADRM1 homolog
Saccharomyces cerevisiae YLR421C   proteasome regulatory particle lid subunit RPN13
Schistosoma mansoni Smp_080040   adhesion regulating molecule 1 (110 kD cell membrane glycoprotein)
Schmidtea mediterranea mk4.008467.00  
Schmidtea mediterranea mk4.001589.00   Putative adhesion regulating molecule 1
Schmidtea mediterranea mk4.010357.00  
Toxoplasma gondii TGME49_224110   adhesion regulating molecule region protein, putative

Essentiality

TGME49_224110 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
CELE_C56G2.7 Caenorhabditis elegans larval arrest wormbase
TGME49_224110 this record Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens adhesion regulating molecule 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.01 1 0.5
0.0443 0.2737 0.3873
0.0509 1 0.5
0.01 1 0.5
0.026 0.5268 1
0.08 1 1
0.0413 0.3008 0.3002
0.0722354 1 0.5
0.0631 0.9198 1
0.0627 0.8941 1
0.0259 1 0.5
0.048 0.5745 1
0.0707 1 1
0.0599 1 0.5
0.01 1 0.5
0.0164 0.5071 0.7437
0.0612 1 1
0.0538 0.331 1
0.0813 1 1
0.0519 0.5762 1
0.01 1 0.5
0.0642 1 1
0.0519 0.5762 1
0.0723 1 1
0.0538 0.331 1
0.0626 0.9465 1
0.0538 0.331 1
0.01 1 0.5
0.0353 1 1
0.0723 1 1
0.0474 0.2844 0.4594
0.026 0.5268 1
0.0376 1 1
0.0722354 1 0.5
0.052 1 0.5
0.01 1 0.5
0.0533 0.8314 1
0.026 0.6826 1
0.0413 0.3008 0.3002

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TGME49_224110 (Toxoplasma gondii), adhesion regulating molecule region protein, putative
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