Detailed view for TGME49_289250

Basic information

TDR Targets ID: 262209
Toxoplasma gondii, cyclophilin, putative
Source Database / ID:  ToxoDB 

pI: 7.2637 | Length (AA): 165 | MW (Da): 18378 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00160   Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

Gene Ontology

Mouse over links to read term descriptions.
GO:0000413   protein peptidyl-prolyl isomerization  
GO:0003755   peptidyl-prolyl cis-trans isomerase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 160 2ok3 (A) 1 160 64.00 0 1 1.8353 -1.42
2 158 2poe (A) 18 177 65.00 0 1 1.83842 -1.65
3 163 1zkc (A) 282 442 51.00 0 1 1.69836 -1.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile ME49 Oocyst. Fritz HM
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Bradyzoite. Gregory Hehl AB Sibley/Greg
Show/Hide expression data references
  • Gregory ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Sibley/Greg ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.

Orthologs

Ortholog group members (OG5_129069)

Species Accession Gene Product
Arabidopsis thaliana AT1G01940   peptidyl-prolyl cis-trans isomerase-like 3
Babesia bovis BBOV_II000200   cyclophilin, putative
Brugia malayi Bm1_30750   peptidyl-prolyl cis-trans isomerase, cyclophilin-type family protein
Caenorhabditis elegans CELE_B0252.4   Protein CYN-10, isoform A
Cryptosporidium hominis Chro.20180   cyclophilin-like protein
Cryptosporidium parvum cgd2_1660   cyclophilin-like protein, putative
Dictyostelium discoideum DDB_G0291734   cyclophilin-type peptidylprolyl cis-trans isomerase
Drosophila melanogaster Dmel_CG11777   CG11777 gene product from transcript CG11777-RA
Echinococcus granulosus EgrG_000894600   peptidyl prolyl cis trans isomerase 3
Echinococcus multilocularis EmuJ_000894600   protein S isoprenylcysteine O methyltransferase
Homo sapiens ENSG00000240344   peptidylprolyl isomerase (cyclophilin)-like 3
Leishmania braziliensis LbrM.34.3570   cyclophilin 7, putative
Leishmania donovani LdBPK_353660.1   peptidyl-prolyl cis-trans isomerase (cyclophilin), putative
Leishmania infantum LinJ.35.3660   cyclophilin 7, putative
Leishmania major LmjF.35.3610   cyclophilin 7, putative
Leishmania mexicana LmxM.34.3610   peptidyl-prolyl cis-trans isomerase (cyclophilin), putative
Loa Loa (eye worm) LOAG_08446   hypothetical protein
Loa Loa (eye worm) LOAG_08445   hypothetical protein
Mus musculus ENSMUSG00000026035   peptidylprolyl isomerase (cyclophilin)-like 3
Neospora caninum NCLIV_041610   cyclophilin, putative
Oryza sativa 4340003   Os06g0130500
Plasmodium berghei PBANKA_0931700   peptidyl-prolyl cis-trans isomerase, putative
Plasmodium falciparum PF3D7_1116300   peptidyl-prolyl cis-trans isomerase
Plasmodium knowlesi PKNH_0914000   peptidyl-prolyl cis-trans isomerase, putative
Plasmodium vivax PVX_091445   cyclophilin, putative
Plasmodium yoelii PY02154   hypothetical protein
Schistosoma mansoni Smp_080150   peptidyl-prolyl cis-trans isomerase
Schmidtea mediterranea mk4.000181.05  
Schmidtea mediterranea mk4.000181.06   Peptidyl-prolyl cis-trans isomerase-like 3
Trypanosoma brucei gambiense Tbg972.9.6990   cyclophilin type peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma brucei Tb927.9.11740   cyclophilin type peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma congolense TcIL3000_9_4760   cyclophilin type peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma cruzi TcCLB.507009.100   cyclophilin, putative
Trypanosoma cruzi TcCLB.510667.60   rotamase, putative
Toxoplasma gondii TGME49_289250   cyclophilin, putative
Theileria parva TP03_0350   peptidyl-prolyl cis-trans isomerase, putative

Essentiality

TGME49_289250 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.2850 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.2850 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.2850 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.2850 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_289250 this record Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TGME49_289250 (Toxoplasma gondii), cyclophilin, putative
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