pI: 6.4523 |
Length (AA): 772 |
MW (Da): 84037 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 11 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
89 | 557 | 1ots (A) | 37 | 445 | 24.00 | 0 | 1 | 0.85 | -1.37 |
570 | 729 | 2d4z (B) | 528 | 770 | 16.00 | 0 | 0.81 | 0.41 | -0.86 |
578 | 729 | 2d4z (B) | 536 | 770 | 14.00 | 0.00005 | 0.94 | 0.4 | -0.68 |
88 | 558 | 1kpl (A) | 36 | 446 | 24.00 | 0 | 1 | 0.703704 | 0.72 |
88 | 558 | 4ene (A) | 36 | 446 | 24.00 | 0 | 0.61 | 0.662704 | 0.74 |
154 | 557 | 4ene (A) | 70 | 445 | 26.00 | 0 | 1 | 0.678516 | 0.58 |
177 | 562 | 3nd0 (A) | 91 | 442 | 28.00 | 0 | 0.35 | 0.6052 | 0.83 |
591 | 742 | 2j9l (A) | 596 | 750 | 22.00 | 0 | 1 | 0.545491 | -0.6 |
678 | 755 | 2yvx (A) | 202 | 280 | 9.00 | 0.015 | 0.09 | 0.116836 | 0.52 |
683 | 727 | 1y5h (A) | 79 | 123 | 13.00 | 0.027 | 0.49 | 0.19709 | 0.19 |
684 | 771 | 3kh5 (A) | 160 | 263 | 17.00 | 0.0051 | 0.38 | 0.15079 | -0.3 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | metacyclic. | Fernandes MC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | amastigotes. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_126837)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G55620 | chloride channel protein CLC-f |
Arabidopsis thaliana | AT4G35440 | chloride channel protein CLC-e |
Brugia malayi | Bm1_19435 | CLC chloride channel protein |
Candida albicans | CaO19.3734 | one of three likely voltage-gated chloride channel genes |
Candida albicans | CaO19.11219 | one of three likely voltage-gated chloride channel genes |
Caenorhabditis elegans | CELE_C07H4.2 | Protein CLH-5 |
Drosophila melanogaster | Dmel_CG5284 | Chloride channel-c |
Escherichia coli | b1592 | H(+)/Cl(-) exchange transporter |
Escherichia coli | b0155 | H(+)/Cl(-) exchange transporter |
Echinococcus granulosus | EgrG_000209700 | H:Cl exchange transporter 4 |
Echinococcus granulosus | EgrG_000843900 | H:Cl exchange transporter 3 |
Echinococcus multilocularis | EmuJ_000843900 | H(+):Cl() exchange transporter 3 |
Echinococcus multilocularis | EmuJ_000209700 | H(+):Cl() exchange transporter 4 |
Homo sapiens | ENSG00000073464 | chloride channel, voltage-sensitive 4 |
Homo sapiens | ENSG00000109572 | chloride channel, voltage-sensitive 3 |
Homo sapiens | ENSG00000171365 | chloride channel, voltage-sensitive 5 |
Leishmania braziliensis | LbrM.01.0210 | CLC-type chloride channel, putative |
Leishmania donovani | LdBPK_010180.1 | CLC-type chloride channel, putative |
Leishmania infantum | LinJ.01.0180 | CLC-type chloride channel, putative |
Leishmania major | LmjF.01.0180 | CLC-type chloride channel, putative |
Leishmania mexicana | LmxM.01.0180 | CLC-type chloride channel, putative |
Loa Loa (eye worm) | LOAG_10527 | chloride channel 3 |
Loa Loa (eye worm) | LOAG_12515 | hypothetical protein |
Mus musculus | ENSMUSG00000000605 | chloride channel 4-2 |
Mus musculus | ENSMUSG00000004317 | chloride channel 5 |
Mus musculus | ENSMUSG00000004319 | chloride channel 3 |
Mycobacterium tuberculosis | Rv0143c | Probable conserved transmembrane protein |
Oryza sativa | 9267257 | Os01g0704700 |
Oryza sativa | 4330553 | Os02g0720700 |
Oryza sativa | 4345939 | Os08g0499200 |
Saccharomyces cerevisiae | YJR040W | Gef1p |
Schistosoma japonicum | Sjp_0019790 | Chloride channel protein 4, putative |
Schistosoma japonicum | Sjp_0019760 | Chloride channel protein 4, putative |
Schistosoma japonicum | Sjp_0052730 | ko:K05012 chloride channel 3, putative |
Schistosoma mansoni | Smp_071970 | chloride channel protein |
Schmidtea mediterranea | mk4.001298.02 | Chloride channel protein,putative |
Schmidtea mediterranea | mk4.052451.01 | |
Schmidtea mediterranea | mk4.001298.03 | |
Trypanosoma cruzi | TcCLB.504797.140 | CLC-type chloride channel, putative |
Trichomonas vaginalis | TVAG_395090 | chloride channel protein 3, 4, putative |
Trichomonas vaginalis | TVAG_032700 | chloride channel, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu144 | Mycobacterium tuberculosis | non-essential | nmpdr |
b0155 | Escherichia coli | non-essential | goodall |
b1592 | Escherichia coli | non-essential | goodall |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.