pI: 6.494 |
Length (AA): 300 |
MW (Da): 33622 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 298 | 3cb2 (A) | 2 | 288 | 26.00 | 0 | 1 | 1.2142 | -0.05 |
2 | 233 | 1z5v (A) | 2 | 210 | 38.00 | 0 | 0.99 | 0.992033 | 0.19 |
3 | 299 | 5eyp (A) | 2 | 282 | 28.00 | 0 | 1 | 1.2302 | -0.31 |
3 | 296 | 4u3j (A) | 2 | 280 | 31.00 | 0 | 1 | 1.2832 | -0.24 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Oocyst, ME49 Bradyzoite. | Fritz HM Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Tachyzoite, ME49 merozoite. | Gregory Hehl AB |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Ortholog group members (OG5_130726)
Species | Accession | Gene Product |
---|---|---|
Echinococcus granulosus | EgrG_000603100 | tubulin epsilon chain |
Echinococcus multilocularis | EmuJ_000603100 | tubulin epsilon chain |
Giardia lamblia | GL50803_6336 | Epsilon tubulin |
Homo sapiens | ENSG00000074935 | tubulin, epsilon 1 |
Leishmania braziliensis | LbrM.21.1240 | epsilon tubulin, putative |
Leishmania donovani | LdBPK_211250.1 | epsilon tubulin, putative |
Leishmania infantum | LinJ.21.1250 | epsilon tubulin, putative |
Leishmania major | LmjF.21.1010 | epsilon tubulin, putative |
Leishmania mexicana | LmxM.21.1010 | epsilon tubulin, putative |
Mus musculus | ENSMUSG00000019845 | epsilon-tubulin 1 |
Neospora caninum | NCLIV_007070 | tubulin epsilon chain, putative |
Plasmodium berghei | PBANKA_1300500 | tubulin epsilon chain, putative |
Plasmodium falciparum | PF3D7_1475700 | tubulin epsilon chain, putative |
Plasmodium knowlesi | PKNH_1246000 | tubulin epsilon chain, putative |
Plasmodium vivax | PVX_118660 | tubulin epsilon chain, putative |
Plasmodium yoelii | PY05777 | tubulin beta chain |
Schistosoma japonicum | Sjp_0009290 | ko:K10391 tubulin epsilon, putative |
Schistosoma mansoni | Smp_028360 | tubulin subunit epsilon |
Schmidtea mediterranea | mk4.013167.01 | Tubulin epsilon chain |
Schmidtea mediterranea | mk4.013167.02 | Tubulin epsilon chain, putative |
Schmidtea mediterranea | mk4.016956.01 | Tubulin epsilon chain, putative |
Schmidtea mediterranea | mk4.023212.00 | Tubulin epsilon chain, putative |
Schmidtea mediterranea | mk4.016956.00 | |
Trypanosoma brucei gambiense | Tbg972.10.1240 | epsilon tubulin |
Trypanosoma brucei | Tb927.10.1140 | epsilon tubulin |
Trypanosoma brucei | Tb11.0530 | epsilon tubulin |
Trypanosoma congolense | TcIL3000_10_940 | epsilon tubulin |
Trypanosoma cruzi | TcCLB.509967.160 | epsilon tubulin, putative |
Trypanosoma cruzi | TcCLB.509695.120 | epsilon tubulin, putative |
Toxoplasma gondii | TGME49_275970 | tubulin, putative |
Toxoplasma gondii | TGME49_275870 | tubulin/FtsZ family, GTPase domain-containing protein |
Trichomonas vaginalis | TVAG_065740 | tubulin gamma chain, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.1140 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.1140 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.1140 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.1140 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1300500 | Plasmodium berghei | Dispensable | plasmo |
TGME49_275870 this record | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_275970 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | epsilon tubulin, putative | Compounds | References |