Detailed view for PVX_092230

Basic information

TDR Targets ID: 265745
Plasmodium vivax, hypothetical protein, conserved
Source Database / ID:  PlasmoDB 

pI: 8.7536 | Length (AA): 1392 | MW (Da): 157479 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 12

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00209   Sodium:neurotransmitter symporter family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0005887   integral to plasma membrane  
GO:0005328   neurotransmitter:sodium symporter activity  
GO:0006836   neurotransmitter transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
482 1047 2a65 (A) 5 465 15.00 0 0.47 0.43 -0.98
2 147 4ilo (A) 24 174 12.00 0.68 0 0.178485 -0.12
39 141 1vh6 (A) 20 116 30.00 0.098 0.28 0.208294 -0.03
480 1080 4xp4 (A) 25 589 27.00 0.000000000028 0.99 0.475053 0.59

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 48 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intraerythrocytic - 6 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_152961)

Species Accession Gene Product
Plasmodium berghei PBANKA_0915900   amino acid transporter, putative
Plasmodium falciparum PF3D7_1132500   amino acid transporter, putative
Plasmodium knowlesi PKNH_0930700   amino acid transporter, putative
Plasmodium vivax PVX_092230   hypothetical protein, conserved
Plasmodium yoelii PY05954   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Macaca fascicularis Dopamine transporter 620 aa 20.6% 671 aa Compounds References
Bos taurus Dopamine transporter 693 aa 20.3% 635 aa Compounds References
Rattus norvegicus Serotonin transporter 630 aa 21.2% 528 aa Compounds References
Macaca mulatta Transporter 620 aa 20.6% 671 aa Compounds References
Rattus norvegicus Dopamine transporter 619 aa 20.1% 657 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0345 0.2718 0.5
0.0345 0.2718 0.5
0.0304 0.2539 0.3918
0.0243 0.2558 1
0.0345 0.2718 0.5
0.0304 0.2539 0.3918
0.0304 0.2539 0.3918
0.0345 0.2718 0.5
0.0382 0.2719 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_092230 (Plasmodium vivax), hypothetical protein, conserved
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