pI: 9.9856 |
Length (AA): 2131 |
MW (Da): 243189 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1483 | 1605 | 1ziv (A) | 215 | 334 | 33.00 | 0.00000016 | 1 | 0.25 | -0.27 |
1522 | 1605 | 2g8j (A) | 268 | 351 | 37.00 | 0.0000012 | 0.46 | 0.35 | -0.29 |
1959 | 2038 | 1zmz (A) | 19 | 98 | 8.00 | 0.00000000099 | 0 | 0.16 | -0.8 |
294 | 517 | 5cwp (A) | 2 | 227 | 12.00 | 0.28 | 0.08 | 0.336315 | -1.51 |
1020 | 1200 | 1ziv (A) | 42 | 211 | 24.00 | 0 | 1 | 0.298837 | -0.14 |
1483 | 1605 | 2p0r (A) | 215 | 334 | 33.00 | 0.00000049 | 1 | 0.253119 | -0.25 |
1483 | 1605 | 2nqa (A) | 223 | 341 | 34.00 | 0.0000026 | 0.69 | 0.320119 | -0.03 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_128932)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_III007670 | calpain family cysteine protease domain containing protein |
Brugia malayi | Bm1_14050 | calpain 7 |
Candida albicans | CaO19.3995 | similar to Aspergillus calpain-like protease PalBory involved in sporulation |
Candida albicans | CaO19.11478 | similar to Aspergillus calpain-like protease PalBory involved in sporulation |
Caenorhabditis elegans | CELE_T04A8.16 | Protein CLP-2 |
Cryptosporidium hominis | Chro.80156 | hypothetical protein |
Cryptosporidium parvum | cgd8_1320 | calpain like thiol protease |
Echinococcus granulosus | EgrG_001000650 | calpain 7 C02 family |
Echinococcus multilocularis | EmuJ_001000650 | calpain 7 (C02 family) |
Homo sapiens | ENSG00000131375 | calpain 7 |
Leishmania braziliensis | LbrM.33.2290 | calpain protease-like protein |
Leishmania donovani | LdBPK_332130.1 | calpain protease-like protein |
Leishmania infantum | LinJ.33.2130 | calpain protease-like protein |
Leishmania major | LmjF.33.2010 | calpain protease-like protein |
Leishmania mexicana | LmxM.32.2010 | calpain protease-like protein |
Loa Loa (eye worm) | LOAG_11530 | calpain |
Mus musculus | ENSMUSG00000021893 | calpain 7 |
Neospora caninum | NCLIV_000790 | hypothetical protein |
Plasmodium berghei | PBANKA_1138400 | calpain, putative |
Plasmodium falciparum | PF3D7_1362400 | calpain |
Plasmodium knowlesi | PKNH_1108900 | calpain, putative |
Plasmodium vivax | PVX_115075 | calpain, putative |
Plasmodium yoelii | PY00976 | Capn7-related |
Saccharomyces cerevisiae | YMR154C | Rim13p |
Schistosoma japonicum | Sjp_0206230 | Probable ubiquitin carboxyl-terminal hydrolase R10E11.3, putative |
Schistosoma japonicum | Sjp_0035290 | ko:K08576 calpain-7, putative |
Schistosoma mansoni | Smp_083530.1 | calpain-7 (C02 family) |
Schistosoma mansoni | Smp_083530.2 | calpain-7 (C02 family) |
Schmidtea mediterranea | mk4.007205.03 | |
Schmidtea mediterranea | mk4.015113.02 | |
Schmidtea mediterranea | mk4.008769.01 | Calpain-7 |
Schmidtea mediterranea | mk4.015113.00 | Calpain-7 |
Trypanosoma brucei gambiense | Tbg972.11.5280 | calpain-like protein, putative |
Trypanosoma brucei | Tb927.11.4640 | calpain-like protein, putative |
Trypanosoma brucei | Tb427tmp.02.2240 | calpain-like protein, putative |
Trypanosoma congolense | TcIL3000.11.4720 | calpain-like protein, putative |
Trypanosoma cruzi | TcCLB.511847.10 | calpain-like cysteine peptidase, putative |
Trypanosoma cruzi | TcCLB.506227.130 | calpain-like cysteine peptidase, putative |
Toxoplasma gondii | TGME49_293820 | calpain family cysteine protease domain-containing protein |
Theileria parva | TP04_0664 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.2240 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.2240 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.2240 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.2240 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1138400 | Plasmodium berghei | Essential | plasmo |
TGME49_293820 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.1
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | calpain protease-like protein | Compounds | References |