Detailed view for PVX_097935
Basic information
Plasmodium vivax, subtilisin-like protease 1
Source Database / ID: PlasmoDB
pI: 6.3313 |
Length (AA): 619 |
MW (Da): 68479 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0006508 proteolysis
Metabolic Pathways
Structural information
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 281 | 589 | 1ic6 (A) | 1 | 279 | 23.00 | 0 | 1 | 0.58 | -0.39 |
| 283 | 583 | 1dbi (A) | 8 | 280 | 31.00 | 0 | 1 | 0.85 | -1.25 |
| 38 | 600 | 4tr2 (A) | 38 | 611 | 98.00 | 0 | 1 | 1.77713 | -0.37 |
| 122 | 202 | 4lvn (P) | 137 | 217 | 73.00 | 0.0000002 | 1 | 1.10226 | -1.56 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
- 4TR2:
-
Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 80-100% percentile | intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 60-80% percentile | intraerythrocytic - 30 hs. | Zhu L |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Mid 40-60% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs. | Zhu L |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Lower 20-40% percentile | intraerythrocytic - 24 hs. | Zhu L |
-
Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.
Orthologs
Ortholog group members (OG5_138369)
| Species | Accession | Gene Product |
|---|---|---|
| Babesia bovis | BBOV_II006080 | subtilisin-like protein, putative |
| Cryptosporidium hominis | Chro.60558 | subtilisin-like serine protease |
| Neospora caninum | NCLIV_021050 | hypothetical protein |
| Plasmodium berghei | PBANKA_1107100 | subtilisin-like protease 1 |
| Plasmodium falciparum | PF3D7_0507500 | subtilisin-like protease 1 |
| Plasmodium knowlesi | PKNH_1026100 | subtilisin-like protease 1, putative |
| Plasmodium vivax | PVX_097935 | subtilisin-like protease 1 |
| Plasmodium yoelii | PY04329 | PfSUB-1 |
| Toxoplasma gondii | TGME49_204050 | subtilisin SUB1 |
Essentiality
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| PBANKA_1107100 | Plasmodium berghei | Essential | plasmo |
| TGME49_204050 | Toxoplasma gondii | Probably non-essential | sidik |
-
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Plasmodium falciparum | Subtilisin-like serine protease | Compounds | References |
By sequence similarity to non orthologous druggable targets
| Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
|---|---|---|---|---|---|---|
| Bacillus lentus | Subtilisin | 269 aa | 29.3% | 280 aa | Compounds | References |
Obtained from network model
Ranking Plot
Putative Drugs List
Assayability
Assay information
Reagent availability
Bibliographic References