Detailed view for PVX_117180
Basic information
Plasmodium vivax, aspartyl proteinase, putative
Source Database / ID: PlasmoDB
pI: 9.9047 |
Length (AA): 373 |
MW (Da): 42458 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0006508 proteolysis
Metabolic Pathways
Structural information
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 9 | 372 | 1miq (A) | 95 | 325 | 25.00 | 0 | 1 | 1.26 | -0.37 |
| 35 | 373 | 3cms () | 0 | 326 | 29.00 | 0 | 1 | 1.27 | -1.19 |
| 45 | 373 | 1tzs (A) | 20 | 342 | 31.00 | 0 | 1 | 1.29 | -1.16 |
| 15 | 371 | 3psg (A) | 22 | 324 | 21.00 | 0.0000000036 | 1 | 1.1423 | 0.23 |
| 21 | 370 | 4amt (A) | 18 | 380 | 34.00 | 0 | 1 | 1.29074 | -0.32 |
| 40 | 126 | 4od9 (A) | 6 | 90 | 45.00 | 0.0000000000055 | 0.81 | 0.625644 | 0.59 |
| 45 | 373 | 1tzs (A) | 20 | 342 | 31.00 | 0 | 1 | 1.25744 | -0.75 |
| 50 | 267 | 1b5f (A) | 14 | 224 | 35.00 | 0 | 1 | 0.96285 | 0.02 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 80-100% percentile | intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 60-80% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 36 hs. | Zhu L |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Mid 40-60% percentile | intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs. | Zhu L |
-
Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.
Orthologs
Ortholog group members (OG5_150586)
| Species | Accession | Gene Product |
|---|---|---|
| Drosophila melanogaster | Dmel_CG10104 | CG10104 gene product from transcript CG10104-RA |
| Neospora caninum | NCLIV_003910 | Cathepsin D enzyme (EC 3.4.23.5), related |
| Plasmodium berghei | PBANKA_1329100 | plasmepsin VIII |
| Plasmodium falciparum | PF3D7_1465700 | plasmepsin VIII, putative |
| Plasmodium knowlesi | PKNH_1215800 | plasmepsin VIII, putative |
| Plasmodium vivax | PVX_117180 | aspartyl proteinase, putative |
| Plasmodium yoelii | PY02004 | Eukaryotic aspartyl protease |
| Toxoplasma gondii | TGME49_209620 | eukaryotic aspartyl protease superfamily protein |
Essentiality
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| PBANKA_1329100 | Plasmodium berghei | Dispensable | plasmo |
| TGME49_209620 | Toxoplasma gondii | Essentiality uncertain | sidik |
-
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Druggability index (range: 0 to 1): 0.6
Known modulators for this target
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
| Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
|---|---|---|---|---|---|---|
| Oryctolagus cuniculus | Renin | 280 aa | 30.5% | 298 aa | Compounds | References |
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References