Detailed view for PVX_080480

Basic information

TDR Targets ID: 266494
Plasmodium vivax, phosphatidylinositol 3-kinase, putative
Source Database / ID:  PlasmoDB 

pI: 9.6574 | Length (AA): 1779 | MW (Da): 200733 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00454   Phosphatidylinositol 3- and 4-kinase
PF00613   Phosphoinositide 3-kinase family, accessory domain (PIK domain)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016301   kinase activity  
GO:0005488   binding  
GO:0004428   inositol or phosphatidylinositol kinase activity  
GO:0048015   phosphoinositide-mediated signaling  
GO:0046854   phosphoinositide phosphorylation  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
861 1293 1e7u (A) 648 1087 24.00 0 1 0.63 -0.47
110 304 5cwn (A) 2 202 13.00 0.099 0.05 0.241812 -0.64
826 1779 5dfz (C) 157 874 33.00 0 1 -0.338744 2.74
1286 1469 4uos (A) 2 183 10.00 0.013 0.02 0.223629 -0.75
1525 1748 4bfr (B) 797 1031 39.00 0 1 0.571613 -0.36
1525 1756 4wwo (A) 831 1072 38.00 0 1 0.58711 -0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_128181)

Species Accession Gene Product
Arabidopsis thaliana AT1G60490   phosphatidylinositol 3-kinase VPS34
Babesia bovis BBOV_I002970   phosphatidylinositol 3- and 4-kinase domain containing protein
Brugia malayi Bm1_09860   Phosphatidylinositol 3- and 4-kinase family protein
Candida albicans CaO19.6243   phosphatidylinositol 3-kinase
Candida albicans CaO19.13621   phosphatidylinositol 3-kinase
Caenorhabditis elegans CELE_B0025.1   Protein VPS-34, isoform A
Cryptosporidium hominis Chro.60213   phosphatidylinositol 3-kinase, root isoform
Cryptosporidium parvum cgd6_1760   phosphatidylinositol 3-kinase; PI3ka plus PI3Kc domains
Dictyostelium discoideum DDB_G0289601   phosphatidylinositol 3-kinase
Drosophila melanogaster Dmel_CG5373   Phosphotidylinositol 3 kinase 59F
Echinococcus granulosus EgrG_000747800   phosphatidylinositol 3 kinase catalytic subunit
Entamoeba histolytica EHI_096560   phosphatidylinositol 3-kinase, putative
Echinococcus multilocularis EmuJ_000747800   Zinc finger, PHD finger
Homo sapiens 5289   phosphatidylinositol 3-kinase, catalytic subunit type 3
Leishmania braziliensis LbrM.24.2090   phosphatidylinositol 3-kinase, putative
Leishmania donovani LdBPK_242090.1   phosphatidylinositol 3-kinase, putative
Leishmania infantum LinJ.24.2090   phosphatidylinositol 3-kinase, putative
Leishmania major LmjF.24.2010   phosphatidylinositol 3-kinase, putative
Leishmania mexicana LmxM.24.2010   phosphatidylinositol 3-kinase, putative
Loa Loa (eye worm) LOAG_11596   phosphatidylinositol 3
Loa Loa (eye worm) LOAG_06080   phosphatidylinositol 3
Mus musculus ENSMUSG00000033628   phosphoinositide-3-kinase, class 3
Neospora caninum NCLIV_052580   phosphatidylinositol 3-kinase, putative
Oryza sativa 4337982   Os05g0180600
Oryza sativa 4345232   Os08g0307400
Plasmodium berghei PBANKA_1114900   phosphatidylinositol 3-kinase, putative
Plasmodium falciparum PF3D7_0515300   phosphatidylinositol 3-kinase
Plasmodium knowlesi PKNH_1017900   phosphatidylinositol 3-kinase, putative
Plasmodium vivax PVX_080480   phosphatidylinositol 3-kinase, putative
Plasmodium yoelii PY00334   phosphatidylinositol 3-kinase vps34-like
Saccharomyces cerevisiae YLR240W   phosphatidylinositol 3-kinase VPS34
Schistosoma japonicum Sjp_0097580   expressed protein
Schistosoma japonicum Sjp_0201680   ko:K00914 phosphatidylinositol 3-kinase [EC2.7.1.137], putative
Schistosoma japonicum Sjp_0311720   ko:K00914 phosphatidylinositol 3-kinase [EC2.7.1.137], putative
Schistosoma mansoni Smp_128130   phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K
Schmidtea mediterranea mk4.016041.01   Phosphatidylinositol 3-kinase catalytic subunit type 3
Schmidtea mediterranea mk4.012968.01  
Schmidtea mediterranea mk4.012968.00   Phosphatidylinositol 3-kinase catalytic subunit type 3
Trypanosoma brucei gambiense Tbg972.8.6270   phosphatidylinositol 3-kinase, putative,PI3-kinase, putative
Trypanosoma brucei Tb927.8.6210   phosphatidylinositol 3-kinase, putative
Trypanosoma congolense TcIL3000_8_6050   phosphatidylinositol 3-kinase, putative
Trypanosoma cruzi TcCLB.511067.4   phosphatidylinositol 3-kinase, putative
Trypanosoma cruzi TcCLB.511903.160   phosphatidylinositol 3-kinase vps34-like
Toxoplasma gondii TGME49_215700   phosphatidylinositol 3- and 4-kinase
Trichomonas vaginalis TVAG_045170   phosphatidylinositol 3-kinase class, putative
Trichomonas vaginalis TVAG_006610   phosphatidylinositol kinase, putative
Trichomonas vaginalis TVAG_247270   phosphatidylinositol 3-kinase class, putative
Trichomonas vaginalis TVAG_332500   phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative

Essentiality

PVX_080480 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.6210 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.6210 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.6210 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.6210 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_B0025.1 Caenorhabditis elegans larval arrest wormbase
CELE_B0025.1 Caenorhabditis elegans slow growth wormbase
YLR240W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1114900 Plasmodium berghei Essential plasmo
TGME49_215700 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphatidylinositol 3-kinase, catalytic subunit type 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0234 0.2696 0.5283
0.0199 0.2635 1
0.0041 0.2934 0
0.0158 0.3211 1
0.0041 0.2934 0
0.009 0.5055 0.5
0.0288 0.281 0.8128
0.0292 0.2702 0.7501
0.0297 0.2714 0.5344
0.0165 0.4277 1
0.0276 0.2771 0.9181
0.0467 0.2566 1
0.0297 0.2725 0.9376
0.0199 0.2635 1
0.013 0.2651 1
0.0272 0.2559 1
0.0615 0.2637 1
0.0299 0.271 0.9268
0.0259 0.2538 0.2336
0.0237 0.2756 0.3292
0.0615 0.2637 1
0.0284 0.278 0.9429
0.0615 0.2637 1
0.0287 0.2519 0.9522
0.0204 0.2521 1
0.029 0.2732 0.9467
0.0031 0.2646 0.5
0.0615 0.2637 1
0.0041 0.2934 0
0.0288 0.2626 0.7451
0.0283 0.2702 0.2912
0.0086 0.2646 0.5
0.0285 0.2771 0.722
0.0283 0.2783 0.9318
0.00473517 0.345018 1
0.0282 0.2701 0.8904
0.0041 0.2934 0
0.0292 0.2725 0.9356
0.0124 0.3064 0
0.0171 0.5405 1
0.0292 0.2783 0.9356
0.0041 0.2934 0
0.033 0.2741 0.1951
0.0055 0.4803 1
0.0086 0.2646 0.5
0.0293 0.2777 0.8215
0.0285 0.2776 0.9214
0.0171 0.5405 1
0.0285 0.2783 0.9074
0.0031 0.2646 0.5
0.0104 0.317 1
0.0085 0.3125 1
0.033 0.2741 0.1951
0.006 0.4276 0.5
0.0279 0.2707 0.5203
0.033 0.2741 0.1951
0.0285 0.2783 0.9074
0.006 0.3683 0.5
0.0171 0.5405 1
0.004 0.2934 0
0.006 0.2646 0.5
0.0156 0.4836 1
0.066 0.2535 1
0.029 0.2701 0.8125

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PVX_080480 (Plasmodium vivax), phosphatidylinositol 3-kinase, putative
Title for this comment
Comment