Detailed view for PVX_089195

Basic information

TDR Targets ID: 266554
Plasmodium vivax, alpha/beta hydrolase, putative
Source Database / ID:  PlasmoDB 

pI: 7.5894 | Length (AA): 512 | MW (Da): 59198 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 278 1l7a (A) 27 318 13.00 0.0000000000094 0.91 1 -1.15
4 282 1lzl (A) 26 318 11.00 0 1 0.8 -0.76
49 280 1tqh (A) 8 246 15.00 0 1 0.87 -1.23
34 277 3ia2 (A) 2 270 14.00 0.0000000016 1 0.494063 0.08
41 163 2o2g (A) 21 150 14.00 0.11 0.1 0.248734 0.27
47 276 3e0x (A) 3 242 12.00 0.15 1 0.610719 -0.36
90 264 3pfb (A) 60 231 28.00 0.028 0.76 0.452497 0.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 24 hs, intraerythrocytic - 30 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_130566)

Species Accession Gene Product
Arabidopsis thaliana AT4G14290   alpha/beta-hydrolase family protein
Arabidopsis thaliana AT4G17150   alpha/beta-Hydrolases superfamily protein
Arabidopsis thaliana AT3G23540   alpha/beta-Hydrolases superfamily protein
Cryptosporidium hominis Chro.70050   random slug cDNA-11 (Fragment)
Cryptosporidium parvum cgd7_370   protein with a conserved N-terminal region
Dictyostelium discoideum DDB_G0272791   alpha/beta hydrolase fold-1 domain-containing protein
Dictyostelium discoideum DDB_G0295699   alpha/beta hydrolase fold-1 domain-containing protein
Leishmania braziliensis LbrM.30.0470   hypothetical protein, conserved
Leishmania donovani LdBPK_300400.1   Alpha/beta hydrolase family, putative
Leishmania infantum LinJ.30.0400   hypothetical protein, conserved
Leishmania major LmjF.30.0400   hypothetical protein, conserved
Leishmania mexicana LmxM.29.0400   hypothetical protein, conserved
Neospora caninum NCLIV_035460   Alpha/beta hydrolase, related
Oryza sativa 9266683   Os02g0197900
Oryza sativa 4341501   Os06g0609700
Plasmodium berghei PBANKA_0707200   alpha/beta hydrolase, putative
Plasmodium falciparum PF3D7_0823400   alpha/beta hydrolase, putative
Plasmodium knowlesi PKNH_1317400   alpha/beta hydrolase, putative
Plasmodium vivax PVX_089195   alpha/beta hydrolase, putative
Plasmodium yoelii PY02678   hypothetical protein
Trypanosoma brucei gambiense Tbg972.6.1510   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.1810   Alpha/beta hydrolase family, putative
Trypanosoma congolense TcIL3000_6_1400   Alpha/beta hydrolase family, putative
Trypanosoma cruzi TcCLB.511491.120   Alpha/beta hydrolase family, putative
Toxoplasma gondii TGME49_271460   protein c14orf29, putative
Trichomonas vaginalis TVAG_292600   conserved hypothetical protein
Trichomonas vaginalis TVAG_316560   Clan SC, family S9, unassigned serine peptidase
Trichomonas vaginalis TVAG_479170   Clan SC, family S9, unassigned serine peptidase
Trichomonas vaginalis TVAG_329180   conserved hypothetical protein
Trichomonas vaginalis TVAG_112980   conserved hypothetical protein
Trichomonas vaginalis TVAG_043720   Clan SC, family S9, unassigned serine peptidase
Trichomonas vaginalis TVAG_233340   conserved hypothetical protein
Trichomonas vaginalis TVAG_112930   conserved hypothetical protein
Trichomonas vaginalis TVAG_011790   Clan SC, family S9, unassigned serine peptidase
Trichomonas vaginalis TVAG_460750   conserved hypothetical protein
Trichomonas vaginalis TVAG_173950   conserved hypothetical protein
Trichomonas vaginalis TVAG_374960   Clan SC, family S33, methylesterase-like serine peptidase
Trichomonas vaginalis TVAG_262420   Clan SC, family S9, unassigned serine peptidase
Trichomonas vaginalis TVAG_369930   conserved hypothetical protein

Essentiality

PVX_089195 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.1810 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.1810 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.1810 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.1810 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_271460 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PVX_089195 (Plasmodium vivax), alpha/beta hydrolase, putative
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