pI: 7.6202 |
Length (AA): 595 |
MW (Da): 68492 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 595 | 1iat (A) | 2 | 550 | 39.00 | 0 | 1 | 1.32 | -0.66 |
3 | 593 | 1t10 (A) | 50 | 599 | 39.00 | 0 | 1 | 1.41 | -0.69 |
1 | 595 | 3qki (A) | 3 | 578 | 81.00 | 0 | 1 | 1.9873 | -1.13 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_126980)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G24620 | phosphoglucose isomerase 1 |
Arabidopsis thaliana | AT5G42740 | glucose-6-phosphate isomerase |
Babesia bovis | BBOV_II000240 | glucose-6-phosphate isomerase protein |
Brugia malayi | Bm1_47625 | glucose phosphate isomerase a |
Candida albicans | CaO19.11369 | phosphoglucose isomerase |
Candida albicans | CaO19.3888 | phosphoglucose isomerase |
Caenorhabditis elegans | CELE_Y87G2A.8 | Protein GPI-1, isoform A |
Cryptosporidium hominis | Chro.20336 | glucose-6-phosphate isomerase |
Cryptosporidium parvum | cgd2_3200 | glucose-6-phosphate isomerase, cytosolic (GPI) (phosphoglucose isomerase) (PGI) (phosphohexose isomerase) (PHI) |
Chlamydia trachomatis | CT_378 | glucose-6-phosphate isomerase |
Dictyostelium discoideum | DDB_G0283673 | glucose-6-phosphate isomerase |
Drosophila melanogaster | Dmel_CG8251 | Phosphoglucose isomerase |
Escherichia coli | b4025 | glucosephosphate isomerase |
Echinococcus granulosus | EgrG_000626300 | glucose 6 phosphate isomerase |
Entamoeba histolytica | EHI_047730 | glucose-6-phosphate isomerase, putative |
Echinococcus multilocularis | EmuJ_000626300 | glucose 6 phosphate isomerase |
Giardia lamblia | GL50803_9115 | Glucose-6-phosphate isomerase |
Homo sapiens | ENSG00000105220 | glucose-6-phosphate isomerase |
Leishmania braziliensis | LbrM.12.0490 | glucose-6-phosphate isomerase |
Leishmania donovani | LdBPK_120490.1 | glucose-6-phosphate isomerase |
Leishmania infantum | LinJ.12.0490 | glucose-6-phosphate isomerase |
Leishmania major | LmjF.12.0530 | glucose-6-phosphate isomerase |
Leishmania mexicana | LmxM.12.0530 | glucose-6-phosphate isomerase |
Loa Loa (eye worm) | LOAG_05350 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01688 | phosphoglucose isomerase |
Loa Loa (eye worm) | LOAG_01687 | hypothetical protein |
Mycobacterium leprae | ML0150c | Probable glucose-6-phosphate isomerase Pgi (phosphoglucose isomerase) (phosphohexose isomerase) (PHI) |
Mus musculus | 14751 | glucose phosphate isomerase 1 |
Mycobacterium tuberculosis | Rv0946c | Probable glucose-6-phosphate isomerase Pgi (GPI) (phosphoglucose isomerase) (phosphohexose isomerase) (phi) |
Mycobacterium ulcerans | MUL_4416 | glucose-6-phosphate isomerase |
Neospora caninum | NCLIV_028830 | Glucose-6-phosphate isomerase (EC 5.3.1.9), related |
Oryza sativa | 4347311 | Os09g0465600 |
Oryza sativa | 4345842 | Os08g0478800 |
Oryza sativa | 4334290 | Os03g0776000 |
Oryza sativa | 4340677 | Os06g0256500 |
Plasmodium berghei | PBANKA_1008800 | glucose-6-phosphate isomerase, putative |
Plasmodium falciparum | PF3D7_1436000 | glucose-6-phosphate isomerase |
Plasmodium knowlesi | PKNH_0422600 | glucose-6-phosphate isomerase |
Plasmodium vivax | PVX_084735 | glucose-6-phosphate isomerase, putative |
Plasmodium yoelii | PY00618 | Phosphoglucose isomerase |
Saccharomyces cerevisiae | YBR196C | glucose-6-phosphate isomerase |
Schistosoma japonicum | Sjp_0301250 | ko:K01810 glucose-6-phosphate isomerase [EC5.3.1.9], putative |
Schistosoma mansoni | Smp_022400 | glucose-6-phosphate isomerase |
Schmidtea mediterranea | mk4.003023.02 | Glucose-6-phosphate isomerase |
Schmidtea mediterranea | mk4.012801.01 | |
Schmidtea mediterranea | mk4.012801.00 | Glucose-6-phosphate isomerase |
Schmidtea mediterranea | mk4.021570.00 | Glucose-6-phosphate isomerase |
Schmidtea mediterranea | mk4.021501.00 | Glucose-6-phosphate isomerase |
Schmidtea mediterranea | mk4.015732.00 | Glucose-6-phosphate isomerase |
Schmidtea mediterranea | mk4.004297.00 | Glucose-6-phosphate isomerase |
Schmidtea mediterranea | mk4.059617.00 | Glucose-6-phosphate isomerase |
Schmidtea mediterranea | mk4.001664.04 | Glucose-6-phosphate isomerase |
Schmidtea mediterranea | mk4.021570.01 | |
Schmidtea mediterranea | mk4.035731.02 | Glucose-6-phosphate isomerase |
Trypanosoma brucei gambiense | Tbg972.1.2390 | glucose-6-phosphate isomerase, glycosomal |
Trypanosoma brucei | Tb927.1.3830 | glucose-6-phosphate isomerase, glycosomal |
Trypanosoma congolense | TcIL3000_0_29570 | glucose-6-phosphate isomerase, glycosomal |
Trypanosoma cruzi | TcCLB.510889.221 | glucose-6-phosphate isomerase, glycosomal, putative |
Trypanosoma cruzi | TcCLB.506529.508 | glucose-6-phosphate isomerase, glycosomal, putative |
Toxoplasma gondii | TGME49_283780 | glucose-6-phosphate isomerase GPI |
Treponema pallidum | TP0475 | glucose-6-phosphate isomerase |
Theileria parva | TP03_0346 | glucose-6-phosphate isomerase, putative |
Trichomonas vaginalis | TVAG_061930 | glucose-6-phosphate isomerase, putative |
Trichomonas vaginalis | TVAG_389760 | glucose-6-phosphate isomerase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu962 | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.1.3830 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.3830 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.3830 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.1.3830 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b4025 | Escherichia coli | non-essential | goodall |
CELE_Y87G2A.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
YBR196C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1008800 | Plasmodium berghei | Essential | plasmo |
TGME49_283780 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Oryctolagus cuniculus | Glucose-6-phosphate isomerase | Compounds | References |
Leishmania major | glucose-6-phosphate isomerase | Compounds | References |
5 literature references were collected for this gene.