pI: 8.3927 |
Length (AA): 195 |
MW (Da): 22813 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 190 | 1ryp (K) | 0 | 190 | 33.00 | 0 | 1 | 1.53 | -1.72 |
1 | 188 | 1iru (K) | 1 | 188 | 43.00 | 0 | 1 | 1.62 | -1.5 |
2 | 195 | 1iru (M) | 10 | 210 | 21.00 | 0 | 1 | 1.35 | -1.34 |
1 | 189 | 4r3o (K) | 1 | 189 | 40.00 | 0 | 1 | 1.47673 | -0.56 |
3 | 192 | 1ryp (M) | 2 | 207 | 23.00 | 0.000042 | 1 | 1.16476 | -0.2 |
3 | 162 | 1ryp (L) | 2 | 159 | 23.00 | 0.042 | 0.99 | 1.08691 | 0.33 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_127700)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G22630 | 20S proteasome beta subunit D1 |
Arabidopsis thaliana | AT4G14800 | 20S proteasome beta subunit D2 |
Babesia bovis | BBOV_I004450 | proteasome beta 2 subunit, putative |
Brugia malayi | Bm1_29265 | proteasome subunit beta type 2 |
Candida albicans | CaO19.11508 | endopeptidase required for mitosis and sporulation |
Candida albicans | CaO19.4025 | endopeptidase required for mitosis and sporulation |
Caenorhabditis elegans | CELE_T20F5.2 | Protein PBS-4 |
Cryptosporidium hominis | Chro.10054 | 20S proteasome beta subunit D2 (PBD2) |
Cryptosporidium parvum | cgd1_420 | 20S proteasome beta subunit D2 (PBD2) , putative |
Dictyostelium discoideum | DDB_G0269472 | 20S proteasome subunit beta-2 |
Drosophila melanogaster | Dmel_CG17302 | Proteasome beta4 subunit-related 2 |
Drosophila melanogaster | Dmel_CG17331 | Proteasome beta4 subunit |
Echinococcus granulosus | EgrG_000481200 | proteasome prosome macropain subunit beta |
Entamoeba histolytica | EHI_078710 | probable proteasome subunit beta type 2, putative |
Echinococcus multilocularis | EmuJ_000481200 | proteasome (prosome, macropain) subunit, beta |
Giardia lamblia | GL50803_3209 | Proteasome subunit beta type 2 |
Homo sapiens | ENSG00000126067 | proteasome (prosome, macropain) subunit, beta type, 2 |
Leishmania braziliensis | LbrM.35.0400 | proteasome beta 2 subunit, putative |
Leishmania donovani | LdBPK_360340.1 | proteasome subunit beta type-2, putative |
Leishmania infantum | LinJ.36.0340 | proteasome beta 2 subunit, putative |
Leishmania major | LmjF.36.0320 | proteasome beta 2 subunit, putative |
Leishmania mexicana | LmxM.36.0320 | proteasome beta 2 subunit, putative |
Loa Loa (eye worm) | LOAG_05258 | proteasome subunit beta type 2 |
Mus musculus | ENSMUSG00000028837 | proteasome (prosome, macropain) subunit, beta type 2 |
Neospora caninum | NCLIV_009170 | Proteasome (Prosome, macropain) subunit, beta type, 1, related |
Oryza sativa | 4333803 | Os03g0695600 |
Plasmodium berghei | PBANKA_1334100 | proteasome subunit beta type-2, putative |
Plasmodium falciparum | PF3D7_1470900 | proteasome subunit beta type-2, putative |
Plasmodium knowlesi | PKNH_1210100 | proteasome subunit beta type-2, putative |
Plasmodium vivax | PVX_116925 | proteasome subunit beta type-2, putative |
Plasmodium yoelii | PY06665 | proteasome subunit beta type 2 |
Saccharomyces cerevisiae | YER012W | proteasome core particle subunit beta 4 |
Schistosoma japonicum | Sjp_0075650 | ko:K02734 20S proteasome subunit beta 4, putative |
Schistosoma mansoni | Smp_074500.1 | proteasome subunit beta 2 (T01 family) |
Schistosoma mansoni | Smp_074500.2 | proteasome subunit beta 2 (T01 family) |
Schmidtea mediterranea | mk4.000953.08 | Proteasome subunit beta type-2 |
Schmidtea mediterranea | mk4.000953.07 | Proteasome subunit beta type-2 |
Trypanosoma brucei gambiense | Tbg972.10.5730 | proteasome beta 2 subunit, putative,20S proteasome subunit |
Trypanosoma brucei | Tb927.10.4710 | proteasome subunit beta type-2, putative |
Trypanosoma congolense | TcIL3000_10_3920 | proteasome subunit beta type-2, putative |
Trypanosoma cruzi | TcCLB.503891.100 | proteasome subunit beta type-2, putative |
Trypanosoma cruzi | TcCLB.510287.30 | 20S proteasome subunit |
Toxoplasma gondii | TGME49_254900 | proteasome subunit beta type 2, putative |
Theileria parva | TP01_0187 | proteasome subunit beta type 2, putative |
Trichomonas vaginalis | TVAG_408570 | Family T1, proteasome beta subunit, threonine peptidase |
Trichomonas vaginalis | TVAG_403280 | Family T1, proteasome beta subunit, threonine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.4710 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.4710 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.4710 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.4710 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T20F5.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T20F5.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T20F5.2 | Caenorhabditis elegans | sterile | wormbase |
YER012W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1334100 | Plasmodium berghei | Essential | plasmo |
TGME49_254900 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.2
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 2 | Compounds | References |