Detailed view for LmjF.28.2780

Basic information

TDR Targets ID: 26808
Leishmania major, heat-shock protein hsp70, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.088 | Length (AA): 658 | MW (Da): 71653 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00012   Hsp70 protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  

Metabolic Pathways

Spliceosome (KEGG)
Endocytosis (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 557 1yuw (A) 1 554 76.00 0 1 1.78 -1.05
6 385 1s3x (A) 6 382 79.00 0 1 1.66 -1.97
397 552 1u00 (A) 389 543 42.00 0 1 0.83 -0.86
398 635 1u00 (A) 390 615 32.00 0 1 0.72 -0.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_126588)

Species Accession Gene Product
Arabidopsis thaliana AT5G02500   heat shock cognate protein 70-1
Arabidopsis thaliana AT3G12580   heat shock protein 70-4
Arabidopsis thaliana AT5G42020   Luminal-binding protein 2
Arabidopsis thaliana AT1G09080   protein BIP3
Arabidopsis thaliana AT3G09440   heat shock protein 70-3
Arabidopsis thaliana AT5G02490   heat shock protein 70
Arabidopsis thaliana AT1G16030   heat shock protein 70B
Arabidopsis thaliana AT5G28540   Luminal-binding protein 1
Arabidopsis thaliana AT1G56410   heat shock protein ERD2
Babesia bovis BBOV_III007800   heat shock protein 70 precursor, putative
Babesia bovis BBOV_III010010   dnaK protein
Brugia malayi Bm1_43675   heat shock 70 kDa protein
Brugia malayi Bm1_07645   heat shock 70 kDa protein C precursor
Candida albicans CaO19.1065   Cytoplasmic chaperone
Candida albicans CaO19.4980   heat shock protein 70
Candida albicans CaO19.13724   HSP70
Candida albicans CaO19.6367   HSP70
Candida albicans CaO19.9564   heat shock protein
Candida albicans CaO19.2013   similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides
Candida albicans CaO19.8667   Cytoplasmic chaperone
Candida albicans CaO19.12447   heat shock protein 70
Caenorhabditis elegans CELE_F26D10.3   Protein HSP-1
Caenorhabditis elegans CELE_F44E5.4   Protein F44E5.4
Caenorhabditis elegans CELE_F44E5.5   Protein F44E5.5
Caenorhabditis elegans CELE_C15H9.6   Protein HSP-3
Caenorhabditis elegans CELE_F43E2.8   Protein HSP-4
Caenorhabditis elegans CELE_C12C8.1   Protein HSP-70
Cryptosporidium hominis Chro.70049   heat shock protein 70 precursor
Cryptosporidium hominis Chro.20010   heat shock protein
Cryptosporidium parvum cgd7_360   heat shock protein, Hsp70
Cryptosporidium parvum cgd2_20   heat shock 70 (HSP70) protein
Dictyostelium discoideum DDB_G0293674   hypothetical protein
Dictyostelium discoideum DDB_G0273249   heat shock cognate protein Hsc70-2
Dictyostelium discoideum DDB_G0293678   hypothetical protein
Dictyostelium discoideum DDB_G0273623   heat shock cognate protein Hsc70-2
Dictyostelium discoideum DDB_G0276445   heat shock protein Hsp70 family protein
Dictyostelium discoideum DDB_G0269144   heat shock cognate protein Hsc70-1
Drosophila melanogaster Dmel_CG31366   Heat-shock-protein-70Aa
Drosophila melanogaster Dmel_CG4147   Heat shock 70-kDa protein cognate 3
Drosophila melanogaster Dmel_CG5436   Heat shock protein 68
Drosophila melanogaster Dmel_CG8937   Heat shock protein cognate 1
Drosophila melanogaster Dmel_CG31449   Heat-shock-protein-70Ba
Drosophila melanogaster Dmel_CG18743   Heat-shock-protein-70Ab
Drosophila melanogaster Dmel_CG7756   Heat shock protein cognate 2
Drosophila melanogaster Dmel_CG4264   Heat shock protein cognate 4
Drosophila melanogaster Dmel_CG31359   Heat-shock-protein-70Bb
Drosophila melanogaster Dmel_CG6489   Heat-shock-protein-70Bc
Drosophila melanogaster Dmel_CG5834   CG5834 gene product from transcript CG5834-RA
Echinococcus granulosus EgrG_000918550   Heat shock 70 kDa protein 4
Echinococcus granulosus EgrG_000520950   heat shock protein 70
Echinococcus granulosus EgrG_000733200   heat shock protein 70b
Echinococcus granulosus EgrG_000366900   heat shock protein 70
Echinococcus granulosus EgrG_000020200   heat shock protein 70
Echinococcus granulosus EgrG_002064000   heat shock protein 70
Echinococcus granulosus EgrG_000726450   heat shock protein 70
Echinococcus granulosus EgrG_001085400   Heat shock 70 kDa protein 4
Echinococcus granulosus EgrG_001202400   Heat shock 70 kDa protein 4
Echinococcus granulosus EgrG_002052600   heat shock protein 70
Echinococcus granulosus EgrG_000020150   heat shock protein 70
Echinococcus granulosus EgrG_000736500   heat shock protein 70
Echinococcus granulosus EgrG_002039100   heat shock protein 70
Echinococcus granulosus EgrG_002100000   heat shock protein 71 kDa protein
Echinococcus granulosus EgrG_000249600   Heat Shock protein family member hsp 3
Echinococcus granulosus EgrG_000651400   heat shock kda protein
Echinococcus granulosus EgrG_000331700   heat shock protein 70
Echinococcus granulosus EgrG_000269650   3'partial|5'partial|heat shock protein 70
Echinococcus granulosus EgrG_002067000   heat shock protein 70
Echinococcus granulosus EgrG_002064200   heat shock protein 70
Echinococcus granulosus EgrG_000554100   heat shock protein 70
Echinococcus granulosus EgrG_000331600   heat shock protein kDa
Echinococcus granulosus EgrG_000161650   heat shock protein 70
Echinococcus granulosus EgrG_000351000   heat shock protein 70
Echinococcus granulosus EgrG_000521700   heat shock protein 70
Echinococcus granulosus EgrG_002064100   heat shock protein 70
Echinococcus granulosus EgrG_002032900   heat shock protein 70
Echinococcus granulosus EgrG_002050850   heat shock protein 70
Echinococcus granulosus EgrG_000521000   heat shock protein 70
Echinococcus granulosus EgrG_002028200   heat shock protein 70
Echinococcus granulosus EgrG_002054100   heat shock protein
Echinococcus granulosus EgrG_000730400   heat shock protein 70
Echinococcus granulosus EgrG_000733450   Heat shock 70 kDa protein
Echinococcus granulosus EgrG_001085050   Heat shock 70 kDa protein 4
Echinococcus granulosus EgrG_000082400   heat shock protein 70
Echinococcus granulosus EgrG_002011350   heat shock protein 70
Echinococcus granulosus EgrG_001085100   heat shock protein 71 kDa protein
Echinococcus granulosus EgrG_000052500   heat shock protein 70
Echinococcus granulosus EgrG_000314800   heat shock protein 70
Echinococcus granulosus EgrG_000723700   Heat shock 70 kDa protein
Echinococcus granulosus EgrG_000314700   heat shock protein 70
Entamoeba histolytica EHI_112590   heat shock protein 70 family
Entamoeba histolytica EHI_113410   heat shock protein 70, putative
Entamoeba histolytica EHI_061640   heat shock protein70, hsp70A2, putative
Entamoeba histolytica EHI_034960   heat shock protein70, hsp70A2, putative
Entamoeba histolytica EHI_188610   heat shock protein 70, putative
Entamoeba histolytica EHI_199590   70 kDa heat shock protein, putative
Entamoeba histolytica EHI_091570   heat shock protein 70, putative
Entamoeba histolytica EHI_192440   heat shock protein70, hsp70A2, putative
Entamoeba histolytica EHI_082800   hypothetical protein
Entamoeba histolytica EHI_052860   heat shock protein 70, putative
Entamoeba histolytica EHI_104330   heat shock protein70, hsp70A2, putative
Entamoeba histolytica EHI_001950   heat shock protein 70 family
Echinococcus multilocularis EmuJ_000730000   heat shock protein 70
Echinococcus multilocularis EmuJ_000366900   heat shock protein 70
Echinococcus multilocularis EmuJ_000291900   heat shock 70 kda protein 1a
Echinococcus multilocularis EmuJ_000003100   heat shock protein 70
Echinococcus multilocularis EmuJ_000298000  
Echinococcus multilocularis EmuJ_000292000   heat shock protein
Echinococcus multilocularis EmuJ_001153700   Heat shock 70 kDa protein
Echinococcus multilocularis EmuJ_000521000   heat shock protein 70
Echinococcus multilocularis EmuJ_000736500   heat shock protein 70
Echinococcus multilocularis EmuJ_000015200   Heat shock protein 70 (HSP70)
Echinococcus multilocularis EmuJ_000014900   heat shock protein 70 related
Echinococcus multilocularis EmuJ_001085400   Heat shock 70 kDa protein 4
Echinococcus multilocularis EmuJ_000297950  
Echinococcus multilocularis EmuJ_001153800   heat shock protein 70 related
Echinococcus multilocularis EmuJ_000351000   heat shock protein 70
Echinococcus multilocularis EmuJ_001085100   Heat shock 70 kDa protein 4
Echinococcus multilocularis EmuJ_001202400   Heat shock 70 kDa protein 4
Echinococcus multilocularis EmuJ_001154000   Heat shock 70 kDa protein
Echinococcus multilocularis EmuJ_000020200   heat shock protein 70
Echinococcus multilocularis EmuJ_000331700   heat shock protein 70
Echinococcus multilocularis EmuJ_000723700   Heat shock 70 kDa protein
Echinococcus multilocularis EmuJ_000710100   heat shock protein 71 kDa protein
Echinococcus multilocularis EmuJ_001154200   Heat shock 70 kDa protein
Echinococcus multilocularis EmuJ_000733500   heat shock protein 70
Echinococcus multilocularis EmuJ_000249600   Heat Shock protein family member (hsp 3)
Echinococcus multilocularis EmuJ_000019500   heat shock 70 kDa protein 1A:1B
Echinococcus multilocularis EmuJ_000314700   heat shock protein 70 related
Echinococcus multilocularis EmuJ_000292300   heat shock protein 70
Echinococcus multilocularis EmuJ_000651400   heat shock kda protein
Echinococcus multilocularis EmuJ_000291400   heat shock protein 70
Echinococcus multilocularis EmuJ_000291700   heat shock protein 70
Echinococcus multilocularis EmuJ_000733300   heat shock protein 70
Echinococcus multilocularis EmuJ_001153600   Heat shock 70 kDa protein
Echinococcus multilocularis EmuJ_000357500   heat shock protein 71 kDa protein
Echinococcus multilocularis EmuJ_000521700   heat shock protein 70
Echinococcus multilocularis EmuJ_000082400   heat shock protein 70 related
Echinococcus multilocularis EmuJ_000032900   heat shock 70 kDa protein 1
Echinococcus multilocularis EmuJ_001153900   heat shock protein kDa heat shock kDa protein
Echinococcus multilocularis EmuJ_000733200   heat shock protein 70b
Echinococcus multilocularis EmuJ_001154300   Heat shock 70 kDa protein
Echinococcus multilocularis EmuJ_000730400   heat shock protein 70
Echinococcus multilocularis EmuJ_000298400  
Echinococcus multilocularis EmuJ_000331600   heat shock protein kDa heat shock kDa protein
Echinococcus multilocularis EmuJ_000019600   heat shock protein 70
Giardia lamblia GL50803_88765   Cytosolic HSP70
Giardia lamblia GL50803_17121   Bip
Homo sapiens ENSG00000044574   heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Homo sapiens ENSG00000204390   heat shock 70kDa protein 1-like
Homo sapiens ENSG00000173110   heat shock 70kDa protein 6 (HSP70B')
Homo sapiens ENSG00000126803   heat shock 70kDa protein 2
Homo sapiens ENSG00000204389   heat shock 70kDa protein 1A
Homo sapiens ENSG00000109971   heat shock 70kDa protein 8
Homo sapiens ENSG00000204388   heat shock 70kDa protein 1B
Leishmania braziliensis LbrM.28.2990   heat-shock protein hsp70, putative
Leishmania braziliensis LbrM.28.1300   glucose-regulated protein 78, putative
Leishmania braziliensis LbrM.26.1260   heat shock protein 70-related protein
Leishmania donovani LdBPK_282960.1   heat-shock protein hsp70, putative
Leishmania donovani LdBPK_283000.1   heat-shock protein hsp70, putative
Leishmania donovani LdBPK_281310.1   luminal binding protein 1 (BiP), putative
Leishmania donovani LdBPK_261220.1   heat shock protein 70-related protein
Leishmania infantum LinJ.28.1310   glucose-regulated protein 78, putative
Leishmania infantum LinJ.28.2950   heat-shock protein hsp70, putative
Leishmania infantum LinJ.28.3060   heat-shock protein hsp70, putative
Leishmania infantum LinJ.26.1220   heat shock protein 70-related protein
Leishmania infantum LinJ.28.3000   heat-shock protein hsp70, putative
Leishmania infantum LinJ.28.2960   heat-shock protein hsp70, putative
Leishmania major LmjF.26.1240   heat shock protein 70-related protein
Leishmania major LmjF.28.2770   heat-shock protein hsp70, putative
Leishmania major LmjF.28.2780   heat-shock protein hsp70, putative
Leishmania major LmjF.28.1200   glucose-regulated protein 78, putative
Leishmania mexicana LmxM.28.2780   heat-shock protein hsp70, putative
Leishmania mexicana LmxM.28.1200   glucose-regulated protein 78, putative
Leishmania mexicana LmxM.28.2770   heat-shock protein hsp70, putative
Leishmania mexicana LmxM.26.1240   heat shock protein 70-related protein
Loa Loa (eye worm) LOAG_03166   hypothetical protein
Loa Loa (eye worm) LOAG_09360   heat shock 70kDa protein 5
Mus musculus ENSMUSG00000015656   heat shock protein 8
Mus musculus ENSMUSG00000090877   heat shock protein 1B
Mus musculus ENSMUSG00000026864   heat shock protein 5
Mus musculus ENSMUSG00000059970   heat shock protein 2
Mus musculus ENSMUSG00000091971   heat shock protein 1A
Mus musculus ENSMUSG00000007033   heat shock protein 1-like
Neospora caninum NCLIV_055490   Heat shock protein 70 (Precursor), related
Neospora caninum NCLIV_033950   Heat shock protein 70, related
Oryza sativa 9271426   Os11g0187800
Oryza sativa 4338568   Os05g0367800
Oryza sativa 4344882   Os08g0197700
Oryza sativa 4339012   Os05g0460000
Oryza sativa 4338866   Os05g0428600
Oryza sativa 4332413   Os03g0276500
Oryza sativa 4351208   Os11g0703900
Oryza sativa 4328075   Os02g0115900
Oryza sativa 4327388   Os01g0840100
Oryza sativa 4332420   Os03g0277300
Oryza sativa 4349971   Os11g0187500
Oryza sativa 4334598   Os03g0821100
Oryza sativa 4332416   Os03g0276800
Oryza sativa 4333877   Os03g0710500
Oryza sativa 9268687   Os12g0569700
Onchocerca volvulus OVOC13484  
Plasmodium berghei PBANKA_0711900   heat shock protein 70
Plasmodium berghei PBANKA_0818900   heat shock protein 70, putative
Plasmodium falciparum PF3D7_0818900   heat shock protein 70
Plasmodium falciparum PF3D7_0917900   heat shock protein 70
Plasmodium falciparum PF3D7_0831700   heat shock protein 70
Plasmodium knowlesi PKNH_1312700   heat shock protein 70, putative
Plasmodium knowlesi PKNH_0715900   heat shock protein, putative
Plasmodium vivax PVX_089425   heat shock 70 kDa protein, putative
Plasmodium vivax PVX_099315   heat shock protein 70, putative
Plasmodium yoelii PY05001   heat shock protein
Plasmodium yoelii PY06158   heat shock protein 70
Saccharomyces cerevisiae YBL075C   Hsp70 family ATPase SSA3
Saccharomyces cerevisiae YDL229W   Hsp70 family ATPase SSB1
Saccharomyces cerevisiae YLL024C   Hsp70 family chaperone SSA2
Saccharomyces cerevisiae YAL005C   Hsp70 family ATPase SSA1
Saccharomyces cerevisiae YJL034W   Hsp70 family ATPase KAR2
Saccharomyces cerevisiae YER103W   Hsp70 family chaperone SSA4
Saccharomyces cerevisiae YNL209W   Hsp70 family ATPase SSB2
Schistosoma japonicum Sjp_0201800   ko:K09490 heat shock 70kDa protein 5, putative
Schistosoma japonicum Sjp_0308630   similar to Heat shock 70 kDa protein cognate 4, putative
Schistosoma japonicum Sjp_0044680   similar to Heat shock 70 kDa protein homolog, putative
Schistosoma japonicum Sjp_0018050   hypothetical protein
Schistosoma mansoni Smp_049550   heat shock protein 70
Schistosoma mansoni Smp_106930.1   heat shock protein 70
Schistosoma mansoni Smp_106930.2   heat shock protein 70
Schmidtea mediterranea mk4.006459.00  
Schmidtea mediterranea mk4.000300.05   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.030972.00  
Schmidtea mediterranea mk4.001665.01  
Schmidtea mediterranea mk4.002168.00  
Schmidtea mediterranea mk4.006315.03  
Schmidtea mediterranea mk4.034193.00   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.002045.03  
Schmidtea mediterranea mk4.026945.01  
Schmidtea mediterranea mk4.018861.02  
Schmidtea mediterranea mk4.016141.00  
Schmidtea mediterranea mk4.019828.00  
Schmidtea mediterranea mk4.001063.11   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.003623.00  
Schmidtea mediterranea mk4.013554.00  
Schmidtea mediterranea mk4.002447.01   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.003261.00   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.013445.01  
Schmidtea mediterranea mk4.023148.00  
Schmidtea mediterranea mk4.005106.01  
Schmidtea mediterranea mk4.033591.01   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.001759.01   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.001195.07  
Schmidtea mediterranea mk4.013978.05   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.000454.11  
Schmidtea mediterranea mk4.021946.01  
Schmidtea mediterranea mk4.033204.00  
Schmidtea mediterranea mk4.010631.00  
Schmidtea mediterranea mk4.000191.21  
Schmidtea mediterranea mk4.000470.07   Heat shock 70 kDa protein cognate 1
Schmidtea mediterranea mk4.010643.04  
Schmidtea mediterranea mk4.000500.06  
Schmidtea mediterranea mk4.014263.00  
Schmidtea mediterranea mk4.042760.00   Heat shock 70 kDa protein cognate 1
Schmidtea mediterranea mk4.020195.01  
Schmidtea mediterranea mk4.001249.01  
Schmidtea mediterranea mk4.008786.00  
Schmidtea mediterranea mk4.031508.02   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.017897.01  
Schmidtea mediterranea mk4.018209.01  
Schmidtea mediterranea mk4.032943.00  
Schmidtea mediterranea mk4.000915.13   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.035858.02   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.022938.02  
Schmidtea mediterranea mk4.006781.00  
Schmidtea mediterranea mk4.005889.01  
Schmidtea mediterranea mk4.000033.21  
Schmidtea mediterranea mk4.011757.00  
Schmidtea mediterranea mk4.003450.01  
Schmidtea mediterranea mk4.026492.00  
Schmidtea mediterranea mk4.002536.01  
Schmidtea mediterranea mk4.005073.01  
Schmidtea mediterranea mk4.001137.12  
Schmidtea mediterranea mk4.018945.01  
Schmidtea mediterranea mk4.000128.05  
Schmidtea mediterranea mk4.003707.00   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.000055.05  
Schmidtea mediterranea mk4.003616.01   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.006708.00  
Schmidtea mediterranea mk4.000019.21  
Schmidtea mediterranea mk4.015685.03   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.012189.01  
Schmidtea mediterranea mk4.023814.00  
Schmidtea mediterranea mk4.025026.00  
Schmidtea mediterranea mk4.000742.02  
Schmidtea mediterranea mk4.004144.03  
Schmidtea mediterranea mk4.002391.01  
Schmidtea mediterranea mk4.020023.01  
Schmidtea mediterranea mk4.007123.03   Putative heat shock protein 70
Schmidtea mediterranea mk4.018113.00  
Schmidtea mediterranea mk4.015280.01  
Schmidtea mediterranea mk4.007204.02  
Schmidtea mediterranea mk4.000976.00   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.018532.02  
Schmidtea mediterranea mk4.004871.03   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.005589.07  
Schmidtea mediterranea mk4.000276.19   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.002751.02   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.007123.02  
Schmidtea mediterranea mk4.013629.00  
Schmidtea mediterranea mk4.017029.00  
Schmidtea mediterranea mk4.001271.03  
Schmidtea mediterranea mk4.025815.00  
Schmidtea mediterranea mk4.006484.02   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.001252.07   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.013998.00   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.021869.02  
Schmidtea mediterranea mk4.020954.01  
Schmidtea mediterranea mk4.004724.00   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.001285.05   Heat shock 70 kDa protein cognate 1
Schmidtea mediterranea mk4.019473.00  
Schmidtea mediterranea mk4.001874.05  
Schmidtea mediterranea mk4.008276.00  
Schmidtea mediterranea mk4.007408.00  
Schmidtea mediterranea mk4.044572.00  
Schmidtea mediterranea mk4.024973.00  
Schmidtea mediterranea mk4.006924.02  
Schmidtea mediterranea mk4.011925.00   Heat shock 70 kDa protein 6
Schmidtea mediterranea mk4.008228.02  
Schmidtea mediterranea mk4.001551.09  
Schmidtea mediterranea mk4.000843.04  
Schmidtea mediterranea mk4.000281.05  
Schmidtea mediterranea mk4.011093.00  
Schmidtea mediterranea mk4.003225.01   Heat shock 70 kDa protein 6
Schmidtea mediterranea mk4.003839.02  
Schmidtea mediterranea mk4.000164.21   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.004050.01  
Schmidtea mediterranea mk4.011066.00   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.025056.03  
Schmidtea mediterranea mk4.026219.00  
Schmidtea mediterranea mk4.011705.00   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.030257.00   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.017521.00  
Schmidtea mediterranea mk4.011463.00  
Schmidtea mediterranea mk4.001831.02  
Schmidtea mediterranea mk4.035257.00  
Schmidtea mediterranea mk4.020975.00  
Schmidtea mediterranea mk4.001033.07  
Schmidtea mediterranea mk4.030227.00  
Schmidtea mediterranea mk4.000133.09  
Schmidtea mediterranea mk4.006431.01  
Schmidtea mediterranea mk4.019923.00  
Schmidtea mediterranea mk4.016268.04   Heat shock 70 kDa protein 6
Schmidtea mediterranea mk4.000114.02  
Schmidtea mediterranea mk4.003472.00   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.003816.01  
Schmidtea mediterranea mk4.011352.03  
Schmidtea mediterranea mk4.010109.00  
Schmidtea mediterranea mk4.030563.00   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.002880.00  
Schmidtea mediterranea mk4.003732.01   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.000975.06  
Schmidtea mediterranea mk4.025532.00  
Schmidtea mediterranea mk4.018283.00  
Schmidtea mediterranea mk4.010109.01  
Schmidtea mediterranea mk4.004590.00  
Schmidtea mediterranea mk4.025203.00  
Schmidtea mediterranea mk4.002118.03  
Schmidtea mediterranea mk4.006763.00   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.017719.00   78 kDa glucose-regulated protein
Schmidtea mediterranea mk4.000226.03  
Schmidtea mediterranea mk4.046795.02   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.007585.01   Heat shock 70 kDa protein A
Schmidtea mediterranea mk4.027566.03  
Schmidtea mediterranea mk4.005619.03  
Schmidtea mediterranea mk4.008973.00   Heat shock 70 kDa protein cognate 1
Schmidtea mediterranea mk4.025223.02  
Schmidtea mediterranea mk4.007853.03  
Schmidtea mediterranea mk4.019343.00  
Trypanosoma brucei gambiense Tbg972.7.640   heat shock 70 kDa protein, putative
Trypanosoma brucei gambiense Tbg972.11.8650   glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative
Trypanosoma brucei gambiense Tbg972.11.8690   glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative
Trypanosoma brucei Tb11.v5.1034   heat shock protein 70 (hsp70), putative
Trypanosoma brucei Tb927.11.11330   heat shock protein 70
Trypanosoma brucei Tb927.11.7460   luminal binding protein 1 (BiP), putative
Trypanosoma brucei Tb927.11.7510   luminal binding protein 1 (BiP), putative
Trypanosoma brucei Tb927.7.710   heat shock 70 kDa protein, putative
Trypanosoma congolense TcIL3000.11.11980   luminal binding protein 1 (BiP), putative
Trypanosoma congolense TcIL3000_0_02950   heat shock 70 kDa protein, putative
Trypanosoma congolense TcIL3000_0_55930   heat shock 70 kDa protein, putative
Trypanosoma congolense TcIL3000.11.11990   luminal binding protein 1 (BiP), putative
Trypanosoma congolense TcIL3000_0_40200   heat shock 70 kDa protein, putative
Trypanosoma congolense TcIL3000_0_54460   heat shock 70 kDa protein, putative
Trypanosoma cruzi TcCLB.511211.170   heat shock protein 70 (hsp70), putative
Trypanosoma cruzi TcCLB.511211.160   heat shock protein 70 (hsp70), putative
Trypanosoma cruzi TcCLB.506585.40   glucose-regulated protein 78, putative
Toxoplasma gondii TGME49_273760   heat shock protein HSP70
Toxoplasma gondii TGME49_311720   chaperonin protein BiP
Theileria parva TP04_0683   heat shock protein 70, putative
Theileria parva TP02_0148   heat shock protein 70
Trichomonas vaginalis TVAG_161100   heat shock protein 70kD, putative
Trichomonas vaginalis TVAG_018930   heat shock protein, putative
Trichomonas vaginalis TVAG_424450   microsomal stress 70 protein ATPase core precursor, putative
Trichomonas vaginalis TVAG_163000   heat shock protein, putative
Trichomonas vaginalis TVAG_092490   heat shock protein 70kD, putative
Trichomonas vaginalis TVAG_151220   heat shock protein 70 (HSP70)-4, putative
Trichomonas vaginalis TVAG_253630   heat shock protein, putative
Trichomonas vaginalis TVAG_044510   heat shock protein 70 (HSP70)-4, putative
Trichomonas vaginalis TVAG_171670   heat shock protein, putative
Trichomonas vaginalis TVAG_206270   heat shock protein, putative
Trichomonas vaginalis TVAG_397610   heat shock protein, putative
Trichomonas vaginalis TVAG_184320   heat shock protein, putative
Trichomonas vaginalis TVAG_137250   heat shock protein 70 (HSP70)-4, putative
Trichomonas vaginalis TVAG_231350   heat shock protein, putative
Trichomonas vaginalis TVAG_300470   heat shock protein, putative

Essentiality

LmjF.28.2780 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.3110 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.3110 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.3110 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.3110 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.02.5450 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.5450 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.5450 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.5450 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.7.710 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.710 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.710 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.710 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F26D10.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_F26D10.3 Caenorhabditis elegans larval arrest wormbase
CELE_F26D10.3 Caenorhabditis elegans larval lethal wormbase
CELE_F26D10.3 Caenorhabditis elegans slow growth wormbase
CELE_F26D10.3 Caenorhabditis elegans sterile wormbase
CELE_C15H9.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_C15H9.6 Caenorhabditis elegans larval arrest wormbase
CELE_C15H9.6 Caenorhabditis elegans slow growth wormbase
CELE_C15H9.6 Caenorhabditis elegans sterile wormbase
CELE_F43E2.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_F43E2.8 Caenorhabditis elegans larval arrest wormbase
CELE_F43E2.8 Caenorhabditis elegans larval lethal wormbase
CELE_F43E2.8 Caenorhabditis elegans slow growth wormbase
CELE_F43E2.8 Caenorhabditis elegans sterile wormbase
CELE_C12C8.1 Caenorhabditis elegans slow growth wormbase
CELE_F44E5.4 Caenorhabditis elegans slow growth wormbase
CELE_F44E5.5 Caenorhabditis elegans slow growth wormbase
YJL034W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0711900 Plasmodium berghei Essential plasmo
TGME49_311720 Toxoplasma gondii Probably essential sidik
TGME49_273760 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens heat shock 70kDa protein 8 Compounds References
Bos taurus Heat shock cognate 71 kDa protein Compounds References
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Compounds References
Homo sapiens heat shock 70kDa protein 1B Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0002 0.5 0.5
0.0004 1 0.5
0.0002 1 0.5
0.0001 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.28.2780 (Leishmania major), heat-shock protein hsp70, putative
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