pI: 6.8698 |
Length (AA): 3247 |
MW (Da): 344856 |
Paralog Number:
5
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
857 | 1353 | 1fmk () | 82 | 528 | 16.00 | 0 | 1 | 0.33 | 0.77 |
1244 | 1344 | 1t46 (A) | 834 | 926 | 23.00 | 0.000015 | 0.6 | 0.32 | -0.89 |
16 | 89 | 2maj (A) | 314 | 386 | 18.00 | 0 | 0.01 | 0.20099 | -1.43 |
2769 | 3236 | 2fo0 (A) | 110 | 513 | 22.00 | 0 | 1 | 0.171133 | 0.94 |
2955 | 3191 | 2f2u (A) | 97 | 308 | 28.00 | 0.0049 | 0.95 | 0.16609 | 0.66 |
2956 | 3241 | 1b6c (B) | 211 | 498 | 23.00 | 0 | 1 | 0.235081 | -0.26 |
2962 | 3166 | 4d1z (A) | 16 | 197 | 41.00 | 0.000000067 | 1 | -0.0057648 | 0.93 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intraerythrocytic - 30 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_129463)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G62110 | DNA-binding domain-containing protein |
Babesia bovis | BBOV_II006750 | hypothetical protein |
Babesia bovis | BBOV_IV007830 | serine/threonine protein kinase, putative |
Babesia bovis | BBOV_II003440 | MIF4G domain containing protein |
Brugia malayi | Bm1_29405 | hypothetical protein |
Cryptosporidium hominis | Chro.20247 | hypothetical protein |
Cryptosporidium hominis | Chro.60196 | MIF4G domain protein |
Cryptosporidium parvum | cgd2_2310 | Ser/Thr protein kinase |
Cryptosporidium parvum | cgd6_1590 | eukaryotic translation initiation factor 4 gamma; Nic domain containing protein |
Loa Loa (eye worm) | LOAG_08886 | hypothetical protein |
Neospora caninum | NCLIV_031430 | protein kinase, putative |
Oryza sativa | 9270578 | Os01g0919300 |
Plasmodium berghei | PBANKA_0902300 | conserved Plasmodium protein, unknown function |
Plasmodium berghei | PBANKA_0110100 | conserved Plasmodium protein, unknown function |
Plasmodium berghei | PBANKA_0939600 | polyadenylate-binding protein-interacting protein 1, putative |
Plasmodium berghei | PBANKA_1415700 | AP2 domain transcription factor, putative |
Plasmodium berghei | PBANKA_0826900 | protein kinase, putative |
Plasmodium berghei | PBANKA_1437500 | AP2 domain transcription factor AP2-G |
Plasmodium berghei | PBANKA_0912600 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_1107300 | polyadenylate-binding protein-interacting protein 1, putative |
Plasmodium falciparum | PF3D7_1317200 | AP2 domain transcription factor, putative |
Plasmodium falciparum | PF3D7_1136000 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_0926100 | protein kinase, putative |
Plasmodium falciparum | PF3D7_0105700 | asparagine-rich antigen Pfa35-2 |
Plasmodium falciparum | PF3D7_0611800 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_1337500 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_1222400 | AP2 domain transcription factor |
Plasmodium falciparum | PF3D7_1222600 | AP2 domain transcription factor AP2-G |
Plasmodium falciparum | PF3D7_1146800 | conserved Plasmodium protein, unknown function |
Plasmodium knowlesi | PKNH_0904900 | polyadenylate-binding protein-interacting protein 1, putative |
Plasmodium knowlesi | PKNH_0944600 | conserved Plasmodium protein, unknown function |
Plasmodium knowlesi | PKNH_0934200 | conserved Plasmodium protein, unknown function |
Plasmodium knowlesi | PKNH_1417900 | AP2 domain transcription factor, putative |
Plasmodium knowlesi | PKNH_0724000 | protein kinase, putative |
Plasmodium knowlesi | PKNH_1441700 | AP2 domain transcription factor AP2-G, putative |
Plasmodium vivax | PVX_091040 | polyadenylate-binding protein-interacting protein 1, putative |
Plasmodium vivax | PVX_099725 | protein kinase, putative |
Plasmodium vivax | PVX_092415 | hypothetical protein, conserved |
Plasmodium vivax | PVX_122680 | transcription factor with AP2 domain(s), putative |
Plasmodium vivax | PVX_092935 | hypothetical protein, conserved |
Plasmodium vivax | PVX_123760 | transcription factor with AP2 domain(s), putative |
Plasmodium yoelii | PY01225 | hypothetical protein |
Plasmodium yoelii | PY07205 | hypothetical protein |
Plasmodium yoelii | PY03447 | hypothetical protein |
Plasmodium yoelii | PY03626 | ERYTHROCYTE MEMBRANE PROTEIN PFEMP3 |
Plasmodium yoelii | PY00194 | hypothetical protein |
Plasmodium yoelii | PY03053 | hypothetical protein |
Plasmodium yoelii | PY07003 | hypothetical protein |
Plasmodium yoelii | PY04926 | hypothetical protein |
Plasmodium yoelii | PY00761 | Protein kinase domain, putative |
Plasmodium yoelii | PY02775 | hypothetical protein |
Toxoplasma gondii | TGME49_231070 | protein kinase |
Theileria parva | TP04_0241 | hypothetical protein |
Theileria parva | TP03_0296 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_0110100 | Plasmodium berghei | Slow | plasmo |
PBANKA_0826900 | Plasmodium berghei | Essential | plasmo |
PBANKA_0902300 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_0912600 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_0939600 | Plasmodium berghei | Essential | plasmo |
PBANKA_1437500 | Plasmodium berghei | Fast | plasmo |
TGME49_231070 | Toxoplasma gondii | Probably non-essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 28.2% | 245 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 27.4% | 179 aa | Compounds | References |