Detailed view for PVX_094935

Basic information

TDR Targets ID: 268420
Plasmodium vivax, cyclin dependent kinase 7 (cdk7), putative
Source Database / ID:  PlasmoDB 

pI: 7.6463 | Length (AA): 325 | MW (Da): 37904 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF12330   Haspin like kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0070985   GO:TFIIK complex  

GO:0008353   RNA polymerase subunit kinase activity  
GO:0005675   holo TFIIH complex  
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 325 1ukh (A) 13 349 29.00 0 1 1.16 -0.47
11 324 1ua2 (A) 13 311 44.00 0 1 1.48 -0.97
24 310 1cm8 (A) 41 313 34.00 0 1 1.3 -1.25
1 325 2rku (A) 45 319 28.00 0 1 1.0971 0.82
5 308 4y72 (A) 0 287 40.00 0 1 1.35848 -0.24
12 321 1ua2 (A) 14 308 45.00 0 1 1.38055 0.08
12 304 2a19 (B) 269 534 28.00 0 0.9 0.811638 1.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 24 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 30 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_141009)

Species Accession Gene Product
Babesia bovis BBOV_IV010230   cyclin-dependent kinase-related kinase, putative
Cryptosporidium hominis Chro.70056   cyclin-dependent kinase-related kinase
Cryptosporidium parvum cgd7_430   cyclin-dependent kinase-related kinase, putative
Neospora caninum NCLIV_036330   CAM kinase, CDPK family, putative
Plasmodium berghei PBANKA_1212800   MO15-related protein kinase
Plasmodium falciparum PF3D7_1014400   MO15-related protein kinase
Plasmodium knowlesi PKNH_0814500   MO15-related protein kinase
Plasmodium vivax PVX_094935   cyclin dependent kinase 7 (cdk7), putative
Plasmodium yoelii PY05139   MO15-related protein kinase Pfmrk
Toxoplasma gondii TGME49_270330   cell-cycle-associated protein kinase, putative
Theileria parva TP01_0781   cyclin-dependent kinase, putative

Essentiality

PVX_094935 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1212800 Plasmodium berghei Essential plasmo
TGME49_270330 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.9

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum MO15-related protein kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 37.7% 297 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 43.7% 295 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 39.7% 297 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 34.1% 205 aa Compounds References
Patiria pectinifera Cdc2 300 aa 36.7% 300 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0121 0.4503 1
0.0116 0.265 0.6671
0.0238 1 0.5
0.0246 1 0.5
0.0007 0.5 0.5
0.0144 0.5643 1
0.0191631 0.292708 1
0.0132 0.2889 0.7334
0.0645 1 1
0.014 0.3351 1
0.0144 0.3136 1
0.0037 1 0.5
0.0123 0.2886 0.7326
0.0119 0.6592 0.5
0.0121 0.3956 0.5
0.0119 0.3337 1
0.0125 0.7758 1
0.0124 0.7152 1
0.0271 0.7225 1
0.0158095 1 1
0.0255 1 1
0.0126 0.3287 0.528
0.049 0.4618 0.9251
0.0012 0.5 0.5
0.0123 1 1
0.024 0.5704 1
0.0246 0.304 1
0.0116 0.3323 1
0.0126 0.3337 0.6025
0.0122 0.3385 1
0.0145 0.3507 0.6235
0.0123 0.9818 1
0.0132 0.3678 1
0.013 0.803 1
0.0124 0.3345 1
0.012 0.372 1
0.0144 0.502 1
0.0258 1 1
0.0493 0.2665 0.438
0.0124 1 1
0.0063 1 1
0.0064 0.3377 0.5
0.0135 0.7914 0.5
0.0126 1 1
0.0646 0.7466 1
0.0098 0.3242 0.2614
0.0062 0.6935 0.5
0.0144 0.4039 0.4039
0.0008 0.5 0.5
0.0118 0.4192 1
0.0144 0.8166 1
0.0257 0.602 1
0.0119 1 1
0.0118 0.3565 1
0.0066 0.3101 0.5
0.0119 0.3232 1
0.0012 0.5 0.5
0.0174281 1 1
0.0118 0.3351 1
0.0123 0.7758 1
0.0118 0.3061 1
0.0144 0.7787 0.9195
0.0123 0.3337 1
0.0092 1 0.5
0.0121 0.7758 1
0.0144 1 1
0.0118 0.7552 1
0.0144 0.2785 1
0.0122 0.5946 1
0.0158095 1 1
0.0126 0.4143 1
0.0029 0.5 0.5
0.0119 0.4045 1
0.012 0.7203 1
0.0125 0.2995 1
0.0362 0.4517 1
0.0121 0.5732 1
0.0641 1 1
0.0131 0.4694 1
0.0137 0.3333 1
0.0003 0.5 0.5
0.0246 0.304 1
0.0778 0.9261 1
0.0145 0.3351 1
0.0358 0.6963 1
0.0091 1 0.5
0.0233 0.2783 1
0.0118 0.2885 0.7321
0.0247 0.5837 1
0.0135 0.3337 1
0.0248 0.2881 1
0.0039 0.5 0.5
0.0121 0.3562 1
0.0766 0.9192 1
0.0119 0.2834 1
0.0123 0.6156 1
0.066227 1 1
0.0643 0.7484 1
0.0117 0.6982 1
0.0059 1 1
0.0144 0.2991 0.7851
0.0018 0.5 0.5
0.01566 0.425028 1
0.0117 0.3115 1
0.012 0.4994 0.4994
0.0116 0.6793 0.5
0.0124 1 1
0.0129 0.4982 1
0.0012 0.5 0.5
0.0115 0.3323 1
0.0116 0.5605 0.5961
0.0341621 0.369837 0.799525
0.0119 1 1
0.0145 0.3353 1
0.0244 1 1
0.0126 1 1
0.0011 1 0.5
0.012 0.7758 1
0.013 0.7346 0.5
0.0756 0.937 1
0.0023 0.5 0.5
0.0123 0.8118 1
0.0125 0.3337 1
0.0169674 1 1
0.0026 0.5 0.5
0.0007 0.5 0.5
0.0069 0.3067 1
0.0247 1 1
0.0118 0.7758 1
0.0117 0.6956 0.5
0.0242 1 1
0.0022 0.3528 1
0.049 0.4618 0.9251
0.0061 0.6883 1
0.0246 0.304 1
0.0119 0.3769 1
0.0033 1 1
0.0118 0.7048 1
0.036 1 1
0.0016 0.5 0.5
0.0119 0.6645 1
0.0144 1 1
0.0116 0.3323 1
0.0131 1 1
0.0039 0.5 0.5
0.0033 0.5 0.5
0.0137 0.3333 1
0.0127 0.6956 0.5
0.0145 0.3507 0.6235
0.0042 0.5 0.5
0.0144 1 1
0.0127 0.2563 1
0.0118 0.3654 1
0.0127 1 1
0.0004 0.5 0.5
0.0121 0.3337 1
0.0081 1 0.5
0.0499 0.4691 0.9507
0.0124 0.7152 1
0.0384 0.3797 1
0.0117 0.3337 1
0.0007 0.5 0.5
0.0036 0.5 0.5
0.0233 0.2783 1
0.014 0.4391 1
0.0259 1 0.5
0.0119 0.3337 1
0.0125 0.2645 1
0.0255 1 1
0.0088 0.4477 0.5
0.0124 0.3337 1
0.0258 0.7934 1
0.0118 0.3337 1
0.0063 0.7244 0.7244
0.0119 0.3337 1
0.0256 0.6923 1
0.0116 0.4566 1
0.0122 0.7054 0.7048
0.0122 0.6599 1
0.0032 0.5 0.5
0.0119 0.3337 1
0.0146 0.3778 1
0.0160435 0.527388 0.782038
0.0118 0.7021 1
0.0132 0.3249 1
0.0144 0.2819 0.5
0.0126 0.3071 1
0.0129 0.8394 1
0.0127 0.7115 0.5
0.0144 0.3136 1
0.0371 0.3281 1
0.0093 0.8828 0
0.0022 0.5 0.5
0.0369 0.445 1
0.0163685 1 1
0.0032 0.5 0.5
0.0245 1 1
0.0364 0.2922 1
0.0039 0.9485 0.5
0.0264 0.2702 0.4026
0.0261 0.2785 0.6129
0.0059 1 1
0.024 1 1
0.0059 1 1
0.0124 0.7048 1
0.0118 0.6956 0.5
0.0067 0.5 0.5
0.0056 1 0.5
0.036 1 1
0.025 1 1
0.0251 1 1
0.0115 0.4002 0.5
0.0116 1 1
0.0117 0.3337 1
0.0027 1 0.5
0.0129 0.2825 1
0.0118 0.3337 1
0.0371 1 1
0.0081 0.5 0.5
0.0137 0.3333 1
0.0126 0.3337 1
0.0118 0.6664 1
0.0379 0.9672 1
0.0144 0.2819 0.5
0.036 0.3189 0.9324
0.0116 0.3124 1
0.0247 1 1
0.0247 0.6497 1
0.0121 0.3337 1
0.049 0.2803 0.6988
0.0129 0.3337 1
0.0022 0.2739 1
0.0016 0.5 0.5
0.024 1 1
0.0257 0.638 1
0.0118 0.43 1
0.0267 0.5837 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PVX_094935 (Plasmodium vivax), cyclin dependent kinase 7 (cdk7), putative
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