Detailed view for PVX_092880

Basic information

TDR Targets ID: 269487
Plasmodium vivax, ABC transporter B family member 3, putative
Source Database / ID:  PlasmoDB 

pI: 10.223 | Length (AA): 783 | MW (Da): 89321 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00005   ABC transporter
PF00664   ABC transporter transmembrane region

Gene Ontology

Mouse over links to read term descriptions.
GO:0042626   ATPase activity, coupled to transmembrane movement of substances  
GO:0016021   integral to membrane  
GO:0017111   nucleoside-triphosphatase activity  
GO:0016887   ATPase activity  
GO:0005524   ATP binding  
GO:0000166   nucleotide binding  
GO:0055085   transmembrane transport  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
402 658 1xmi (B) 388 638 24.00 0 1 0.43 0.26
419 658 1z47 (A) 11 238 23.00 0 1 0.63 -1.13
140 782 4f4c (A) 9 635 18.00 0 1 0.685701 0.88
545 782 5eum (A) 335 566 30.00 0 1 0.724559 -0.69
555 782 2ixe (A) 478 702 30.00 0 1 0.749788 -0.87
557 781 2ff7 (A) 468 685 35.00 0 1 0.741956 -0.43

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 18 hs, intraerythrocytic - 24 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 30 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_152077)

Species Accession Gene Product
Plasmodium berghei PBANKA_0903500   ABC transporter B family member 3, putative
Plasmodium falciparum PF3D7_1145500   ABC transporter B family member 3, putative
Plasmodium knowlesi PKNH_0943400   ABC transporter B family member 3, putative
Plasmodium vivax PVX_092880   ABC transporter B family member 3, putative
Plasmodium yoelii PY06546   transport protein-related

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0226 0.2607 0.1574
0.0107 0.2982 0.2976
0.0096 0.2671 0
0.0054 0.2631 0
0.01 0.2539 0
0.0038 0.2684 0
0.0064 0.2602 0
0.0029 0.2983 0.3702
0.0053 0.2821 0
0.0107 0.2591 0
0.0038 0.2684 0
0.0086 0.2826 0
0.0101 0.3024 0
0.0212 0.2836 0.1869
0.0101 0.297 0.297
0.0103 0.2692 0
0.01 0.2525 0
0.011 0.2652 0.2652
0.0125 0.2942 0
0.0057 0.2538 0.2443
0.0097 0.2874 0
0.0178 0.289 0.5648
0.0117 0.2609 0
0.0102 0.2778 0.2725
0.0119 0.2763 0
0.0177 0.2919 0.4309
0.0074 0.2667 0.2495
0.0157 0.2814 0.5243
0.0064 0.2606 0.2232
0.0086 0.2819 0
0.0113 0.283 0
0.0053 0.2821 0
0.0105 0.2581 0.0014
0.0032 0.2584 0.2433
0.0074 0.2584 0
0.0055 0.2884 0.2884
0.0042 0.2624 0
0.0038 0.2692 0.4673
0.0206 0.2586 0.2206
0.0088 0.2555 0.2555
0.0206 0.2785 0.2732
0.0087 0.2825 0
0.0029 0.2983 0.3702
0.0074 0.2621 0.2491
0.0029 0.2983 0.3702
0.0199 0.2537 0.2994
0.0077 0.2708 0
0.0068 0.2634 0
0.0086 0.2639 0
0.0124 0.2765 0
0.0079 0.2588 0
0.0117 0.2589 0.2781
0.009 0.2658 0
0.003 0.2602 0.2457
0.013 0.28 0
0.0109 0.2892 0
0.0105 0.2629 0.2629
0.0029 0.2983 0.3702
0.0161 0.2787 0.2722
0.0117 0.2749 0
0.0065 0.2573 0
0.005 0.2958 0
0.0126 0.2956 0
0.0133 0.2951 0
0.0137 0.2918 0.2678
0.0082 0.2995 0.5092
0.0086 0.2635 0.2346
0.0129 0.2892 0.2712
0.0146 0.2695 0.2381
0.0113 0.2726 0.2677
0.0065 0.2748 0.269
0.0123 0.2787 0
0.0087 0.2619 0
0.0122 0.2698 0.2698
0.0199 0.2537 0.2994
0.0204 0.2853 0.3044
0.0091 0.286 0
0.0074 0.2596 0
0.0061 0.2824 0
0.0068 0.2504 0
0.0068 0.2634 0
0.0226 0.2574 0.1564
0.0101 0.297 0.297
0.0254 0.2524 0.2783
0.0063 0.3239 0.3239
0.0085 0.2691 0
0.0055 0.2531 0
0.0089 0.2637 0
0.0099 0.2891 0.278
0.0101 0.2856 0
0.0271 0.2507 0.2166
0.0088 0.2555 0.2555
0.0038 0.2692 0.4673
0.0133 0.2801 0
0.0177 0.2919 0.4309
0.0136 0.2913 0.2749
0.0126 0.3471 0.4107

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_092880 (Plasmodium vivax), ABC transporter B family member 3, putative
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