Detailed view for PVX_118000

Basic information

TDR Targets ID: 269607
Plasmodium vivax, exosome complex exonuclease RRP6, putative
Source Database / ID:  PlasmoDB 

pI: 6.0657 | Length (AA): 1114 | MW (Da): 127512 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00570   HRDC domain
PF01612   3'-5' exonuclease

Gene Ontology

Mouse over links to read term descriptions.
GO:0006139   nucleobase, nucleoside, nucleotide and nucleic acid metabolic process  
GO:0005622   intracellular  
GO:0008408   3'-5' exonuclease activity  
GO:0003824   catalytic activity  
GO:0003676   nucleic acid binding  
GO:0000166   nucleotide binding  
GO:0044237   cellular metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
360 835 2hbj (A) 127 515 24.00 0 1 0.49 0.3
755 826 1wud (A) 530 601 15.00 0.0000000019 0.98 0.58 -2.8
1 106 1fxk (A) 7 111 13.00 0.94 0.03 0.267953 -0.89
59 273 2fkj (A) 40 244 28.00 0.19 0.04 0.180298 1.22
342 874 5c0w (K) 82 531 27.00 0 1 0.453756 0.9
420 629 3saf (A) 256 456 32.00 0 1 0.62481 -0.71
941 1113 4tql (A) 10 187 11.00 0.81 0.01 0.289396 -0.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_156271)

Species Accession Gene Product
Cryptosporidium parvum cgd5_100   RRPp/PMC2 like exosome 3-5 exoribonuclease subunit with an RNAseD domain and an HRDc domain
Plasmodium berghei PBANKA_1313400   exosome complex exonuclease RRP6, putative
Plasmodium falciparum PF3D7_1449700   exosome complex exonuclease RRP6
Plasmodium knowlesi PKNH_1232400   exosome complex exonuclease RRP6, putative
Plasmodium vivax PVX_118000   exosome complex exonuclease RRP6, putative
Theileria parva TP03_0385   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_118000 (Plasmodium vivax), exosome complex exonuclease RRP6, putative
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