Detailed view for PVX_110910

Basic information

TDR Targets ID: 269645
Plasmodium vivax, DNA polymerase zeta catalytic subunit, putative
Source Database / ID:  PlasmoDB 

pI: 8.7263 | Length (AA): 1880 | MW (Da): 216018 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00136   DNA polymerase family B
PF03104   DNA polymerase family B, exonuclease domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0019985   bypass DNA synthesis  
GO:0016035   zeta DNA polymerase complex  
GO:0003677   DNA binding  
GO:0003676   nucleic acid binding  
GO:0000166   nucleotide binding  
GO:0003887   DNA-directed DNA polymerase activity  
GO:0006281   DNA repair  
GO:0006260   DNA replication  

Metabolic Pathways

Global map (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
452 1370 1s5j (A) 43 860 16.00 0 0.99 0.07 1.33
493 1465 1d5a (A) 4 756 15.00 0 1 0.16 0.89
199 412 4tql (A) 9 213 15.00 0.089 0.37 0.26003 -0.46
422 1447 3iay (A) 95 974 18.00 0 1 0.462945 1.26
1145 1328 4ahc (B) 448 632 26.00 0.00015 1 0.351672 0.59

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 18 hs, intraerythrocytic - 24 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_205138)

Species Accession Gene Product
Plasmodium falciparum PF3D7_1037000   DNA polymerase zeta catalytic subunit, putative
Plasmodium knowlesi PKNH_0621500   DNA polymerase zeta catalytic subunit, putative
Plasmodium vivax PVX_110910   DNA polymerase zeta catalytic subunit, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0051 0.2561 0
0.0662 0.254 0
0.0202 0.2808 0
0.0818 0.3027 0
0.0148 0.335 0.2999
0.0129 0.2965 0.3403
0.0856 0.3223 0.3219
0.0023 1 0.5
0.0129 0.2522 0
0.0334 0.266 0
0.08 0.2545 0
0.0856 0.3223 0.3219
0.057 0.2753 0.3328
0.021 0.3148 0.3072
0.0147 0.2972 0.2972
0.0473 0.2924 0.2924
0.0818 0.3027 0
0.0147 0.2972 0.2972
0.0334 0.266 0
0.0473 0.2924 0.2924
0.0856 0.3223 0.3219
0.0521 0.296 0.296
0.0294 0.3069 0
0.0341 0.2867 0.2867
0.0473 0.2924 0.2924
0.0856 0.3223 0.3219

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_110910 (Plasmodium vivax), DNA polymerase zeta catalytic subunit, putative
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