pI: 4.9489 |
Length (AA): 303 |
MW (Da): 34629 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
53 | 303 | 1rz4 (A) | 9 | 214 | 16.00 | 0 | 0.8 | 0.73 | -0.58 |
27 | 274 | 4b0z (A) | 0 | 222 | 29.00 | 0 | 1 | 1.03568 | -0.19 |
35 | 302 | 3t5v (A) | 263 | 539 | 15.00 | 0 | 0.94 | 0.890688 | 0.26 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 40 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intraerythrocytic - 48 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_128073)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G42040 | 26S proteasome non-ATPase regulatory subunit RPN12B |
Arabidopsis thaliana | AT1G64520 | 26S proteasome non-ATPase regulatory subunit RPN12A |
Babesia bovis | BBOV_III003610 | 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein |
Brugia malayi | Bm1_45690 | 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein |
Brugia malayi | Bm1_44745 | 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein |
Candida albicans | CaO19.7845 | similar to S. cerevisiae RPN12 (YFR052W) subunit of the 19S regulatory particle of the 26S proteasome |
Candida albicans | CaO19.213 | similar to S. cerevisiae RPN12 (YFR052W) subunit of the 19S regulatory particle of the 26S proteasome |
Caenorhabditis elegans | CELE_ZK20.5 | Protein RPN-12 |
Cryptosporidium hominis | Chro.20354 | hypothetical protein |
Cryptosporidium parvum | cgd2_3370 | proteasome regulatory subunit Rpn12 family |
Dictyostelium discoideum | DDB_G0273979 | 26S proteasome non-ATPase regulatory subunit 8 |
Dictyostelium discoideum | DDB_G0272564 | 26S proteasome non-ATPase regulatory subunit 8 |
Drosophila melanogaster | Dmel_CG11552 | Regulatory particle non-ATPase 12-related |
Drosophila melanogaster | Dmel_CG4157 | Regulatory particle non-ATPase 12 |
Echinococcus granulosus | EgrG_000795500 | 26S proteasome non ATPase regulatory subunit 8 |
Entamoeba histolytica | EHI_200220 | proteasome regulatory subunit, putative |
Echinococcus multilocularis | EmuJ_000795500 | 26S proteasome non ATPase regulatory subunit 8 |
Homo sapiens | ENSG00000099341 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 |
Leishmania braziliensis | LbrM.32.1350 | proteasome regulatory non-ATP-ase subunit, putative |
Leishmania donovani | LdBPK_321260.1 | proteasome regulatory non-ATP-ase subunit, putative |
Leishmania infantum | LinJ.32.1260 | proteasome regulatory non-ATP-ase subunit, putative |
Leishmania major | LmjF.32.1200 | proteasome regulatory non-ATP-ase subunit, putative |
Leishmania mexicana | LmxM.31.1200 | proteasome regulatory non-ATP-ase subunit, putative |
Loa Loa (eye worm) | LOAG_02141 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08779 | hypothetical protein |
Mus musculus | ENSMUSG00000030591 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 |
Neospora caninum | NCLIV_066370 | hypothetical protein |
Oryza sativa | 4343069 | Os07g0435100 |
Plasmodium berghei | PBANKA_0410300 | 26S proteasome regulatory subunit RPN12, putative |
Plasmodium falciparum | PF3D7_0312300 | 26S proteasome regulatory subunit RPN12, putative |
Plasmodium knowlesi | PKNH_0830100 | 26S proteasome regulatory subunit RPN12, putative |
Plasmodium vivax | PVX_119720 | 26S proteasome regulatory subunit RPN12, putative |
Plasmodium yoelii | PY01718 | hypothetical protein |
Saccharomyces cerevisiae | YFR052W | proteasome regulatory particle lid subunit RPN12 |
Schistosoma japonicum | Sjp_0024600 | ko:K03031 26S proteasome regulatory subunit N12, putative |
Schistosoma mansoni | Smp_047740 | 26S proteasome non-ATPase regulatory subunit |
Schmidtea mediterranea | mk4.003873.04 | 26S proteasome non-ATPase regulatory subunit 8 |
Schmidtea mediterranea | mk4.001636.00 | 26S proteasome non-ATPase regulatory subunit 8 |
Schmidtea mediterranea | mk4.000673.02 | 26S proteasome non-ATPase regulatory subunit 8 |
Schmidtea mediterranea | mk4.012294.00 | 26S proteasome non-ATPase regulatory subunit 8 |
Schmidtea mediterranea | mk4.025000.00 | 26S proteasome non-ATPase regulatory subunit 8 |
Trypanosoma brucei gambiense | Tbg972.11.16170 | proteasome regulatory non-ATP-ase subunit, putative |
Trypanosoma brucei | Tb927.11.14430 | proteasome regulatory non-ATP-ase subunit |
Trypanosoma congolense | TcIL3000.11.14720 | proteasome regulatory non-ATP-ase subunit |
Trypanosoma cruzi | TcCLB.511725.10 | proteasome regulatory non-ATPase subunit, putative |
Toxoplasma gondii | TGME49_250830 | SAC3/GANP family protein |
Theileria parva | TP03_0046 | 26S proteasome regulatory subunit S14, putative |
Trichomonas vaginalis | TVAG_321570 | 26S proteasome non-ATPase regulatory subunit, putative |
Trichomonas vaginalis | TVAG_171960 | 26S proteasome non-ATPase regulatory subunit, putative |
Trichomonas vaginalis | TVAG_253730 | 26S proteasome non-ATPase regulatory subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.6030 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.6030 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.6030 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.6030 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
YFR052W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0410300 | Plasmodium berghei | Slow | plasmo |
TGME49_250830 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | Compounds | References |