Detailed view for PVX_092830

Basic information

TDR Targets ID: 270432
Plasmodium vivax, ubiquitin activating enzyme, putative
Source Database / ID:  PlasmoDB 

pI: 5.3418 | Length (AA): 359 | MW (Da): 40875 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00899   ThiF family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0008641   small protein activating enzyme activity  
GO:0008152   metabolic process  

Metabolic Pathways

Ubiquitin mediated proteolysis (KEGG)

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 359 1ngv (A) 6 533 21.00 0 1 0.39 0.22
8 352 1y8q (A) 14 337 25.00 0 1 0.97 -0.36
1 359 1y8q (A) 11 344 23.00 0 1 0.8925 0.17
4 172 1jw9 (B) 3 175 18.00 0.00000000018 0.96 0.738052 -0.31
6 351 1y8q (A) 12 336 25.00 0 1 1.12409 0.1
29 212 4kbb (A) 956 1120 32.00 0.91 0.04 0.409135 2.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_128859)

Species Accession Gene Product
Arabidopsis thaliana AT5G50580   SUMO-activating enzyme subunit 1B
Arabidopsis thaliana AT5G50680   SUMO-activating enzyme subunit 1B
Arabidopsis thaliana AT4G24940   SUMO-activating enzyme subunit 1A
Babesia bovis BBOV_I000150   conserved hypothetical protein
Brugia malayi Bm1_25525   ThiF family protein
Candida albicans CaO19.10353   similar to S. cerevisiae AOS1 (YPR180W) which mediates conjugation of ubiquitin-like Smt3p (sumoylation) to target proteins
Candida albicans CaO19.2835   similar to S. cerevisiae AOS1 (YPR180W) which mediates conjugation of ubiquitin-like Smt3p (sumoylation) to target proteins
Caenorhabditis elegans CELE_C08B6.9   Protein AOS-1
Dictyostelium discoideum DDB_G0279641   sumo-activating enzyme subunit 1
Drosophila melanogaster Dmel_CG12276   CG12276 gene product from transcript CG12276-RA
Echinococcus granulosus EgrG_000844900   SUMO activating enzyme subunit 1
Echinococcus multilocularis EmuJ_000844900   SUMO activating enzyme subunit 1
Homo sapiens ENSG00000142230   SUMO1 activating enzyme subunit 1
Loa Loa (eye worm) LOAG_02750   hypothetical protein
Mus musculus ENSMUSG00000052833   SUMO1 activating enzyme subunit 1
Neospora caninum NCLIV_011590   hypothetical protein
Oryza sativa 4350554   Os11g0497000
Plasmodium berghei PBANKA_0904500   SUMO-activating enzyme subunit 1, putative
Plasmodium falciparum PF3D7_1144500   SUMO-activating enzyme subunit 1
Plasmodium knowlesi PKNH_0942400   SUMO-activating enzyme subunit 1, putative
Plasmodium vivax PVX_092830   ubiquitin activating enzyme, putative
Plasmodium yoelii PY00295   SUMO-1 activating enzyme subunit 1
Saccharomyces cerevisiae YPR180W   E1 ubiquitin-activating protein AOS1
Schistosoma japonicum Sjp_0208640   ko:K10684 ubiquitin-like 1-activating enzyme E1 A, putative
Schistosoma mansoni Smp_048760.2   sumo-1-activating enzyme E1a
Schistosoma mansoni Smp_048760.1   sumo-1-activating enzyme E1a
Schmidtea mediterranea mk4.001193.04   SUMO-activating enzyme subunit aos-1
Toxoplasma gondii TGME49_211390   hypothetical protein
Theileria parva TP03_0841   hypothetical protein
Theileria parva TP03_0840   hypothetical protein

Essentiality

PVX_092830 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C08B6.9 Caenorhabditis elegans embryonic lethal wormbase
CELE_C08B6.9 Caenorhabditis elegans larval arrest wormbase
CELE_C08B6.9 Caenorhabditis elegans sterile wormbase
YPR180W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0904500 Plasmodium berghei Essential plasmo
TGME49_211390 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens SUMO1 activating enzyme subunit 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0058 0.2625 1
0.0058 0.7978 1
0.005 0.2639 0.6018
0.0048 0.319 1
0.0048 0.2555 1
0.0058 0.2575 0.5148
0.0058 0.3355 1
0.0058 0.3355 1
0.0058 1 1
0.0054 0.6043 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PVX_092830 (Plasmodium vivax), ubiquitin activating enzyme, putative
Title for this comment
Comment