Detailed view for PVX_098690

Basic information

TDR Targets ID: 270513
Plasmodium vivax, copper-transporting ATPase, putative
Source Database / ID:  PlasmoDB 

pI: 6.6818 | Length (AA): 2073 | MW (Da): 231269 | Paralog Number: 0

Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 6

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00122   E1-E2 ATPase
PF00702   haloacid dehalogenase-like hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0016021   integral to membrane  
GO:0005524   ATP binding  
GO:0003824   catalytic activity  
GO:0000166   nucleotide binding  
GO:0046872   metal ion binding  
GO:0008152   metabolic process  
GO:0006754   ATP biosynthetic process  
GO:0030001   metal ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
342 511 2ew9 (A) 4 149 20.00 0 0.94 0.23 -0.26
441 511 1aw0 () 2 72 11.00 0 0.27 0.43 -2.64
1712 2005 2b8e (A) 423 663 25.00 0 1 0.1 0.44
1815 2005 1l7m (A) 3 211 18.00 0 0.51 0.25 -0.41
32 66 2emw (A) 1 35 14.00 0.044 0.02 0.0489837 0.53
247 315 1q8l (A) 16 84 7.00 0.00085 0 0.197685 -1.1
1223 1286 2hc8 (A) 239 301 38.00 0.00016 0.36 0.377973 0.51
1224 1308 2kij (A) 34 117 29.00 0.0018 0.69 0.374103 0.08
1855 2067 4bbj (A) 522 732 31.00 0 0.96 0.35985 1.31
1862 2005 2yj3 (A) 493 633 38.00 0.000000047 1 0.321565 1
1863 2010 3skx (A) 490 633 34.00 0 1 0.459494 0.24
1879 2008 3ar4 (A) 594 751 29.00 0.0053 1 0.184811 0.3
1915 2026 4hqj (A) 666 777 28.00 0.056 0.49 0.270128 0.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_168155)

Species Accession Gene Product
Plasmodium vivax PVX_098690   copper-transporting ATPase, putative
Plasmodium yoelii PY00066   putative copper efflux ATPase
Toxoplasma gondii TGME49_226100   haloacid dehalogenase family hydrolase domain-containing protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PVX_098690 (Plasmodium vivax), copper-transporting ATPase, putative
Title for this comment
Comment