Detailed view for LmjF.33.1980

Basic information

TDR Targets ID: 27637
Leishmania major, serine/threonine-protein kinase a, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.0127 | Length (AA): 448 | MW (Da): 50591 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00169   PH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 444 1omw (A) 137 650 17.00 0 1 0.94 0.24
13 444 1omw (A) 168 650 20.00 0 1 1.12 -0.05
35 284 1rdq (E) 42 280 27.00 0 1 0.97 -1.05
13 444 3pvu (A) 168 650 21.00 0 1 1.04939 0.84
145 250 4m66 (A) 125 249 41.00 0.00022 0.6 0.406707 1.02
350 446 4a6f (A) 467 581 18.00 0 0.66 0.498818 -1.2
354 445 5efx (A) 475 570 21.00 0 0.92 0.544657 -1.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_184040)

Species Accession Gene Product
Leishmania braziliensis LbrM.33.2260   serine/threonine-protein kinase a, putative
Leishmania donovani LdBPK_332100.1   serine/threonine-protein kinase a, putative
Leishmania infantum LinJ.33.2100   serine/threonine-protein kinase a, putative
Leishmania major LmjF.33.1980   serine/threonine-protein kinase a, putative
Leishmania mexicana LmxM.32.1980   serine/threonine-protein kinase a, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 26.8% 287 aa Compounds References
Patiria pectinifera Cdc2 300 aa 26.3% 289 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 25.4% 283 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0004 0.5 0.5
0.0003 0.5 0.5
0.0036 0.5 0.5
0.0059 1 1
0.0007 0.5 0.5
0.0039 0.9485 0.5
0.0032 0.5 0.5
0.0033 1 1
0.0062 0.6935 0
0.0061 0.6883 0.5304
0.0032 0.5 0.5
0.0042 0.5 0.5
0.0064 0.3377 0
0.0011 1 0.5
0.0008 0.5 0.5
0.0066 0.3101 0
0.0033 0.5 0.5
0.0063 1 1
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0007 0.5 0.5
0.0063 0.7244 0.2543
0.0039 0.5 0.5
0.0092 1 0.5
0.0069 0.3067 1
0.0098 0.3242 0.2614
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0029 0.5 0.5
0.0039 0.5 0.5
0.0037 1 0.5
0.0056 1 0.5
0.0026 0.5 0.5
0.0018 0.5 0.5
0.0059 1 1
0.0081 1 0.5
0.0022 0.5 0.5
0.0012 0.5 0.5
0.0093 0.8828 0
0.0081 0.5 0.5
0.0016 0.5 0.5
0.0027 1 0.5
0.0059 1 1
0.0012 0.5 0.5
0.0067 0.5 0.5
0.0091 1 0.5
0.0088 0.4477 1

Assayability

Assay information

  • Assay for Protein Kinase C (2.7.1.37 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

141 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.33.1980 (Leishmania major), serine/threonine-protein kinase a, putative
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