Detailed view for LmjF.07.0730

Basic information

TDR Targets ID: 27811
Leishmania major, malonyl-coa decarboxylase-like protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.478 | Length (AA): 793 | MW (Da): 85805 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05292   Malonyl-CoA decarboxylase C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0050080   malonyl-CoA decarboxylase activity  
GO:0006633   fatty acid biosynthetic process  

Metabolic Pathways

beta-Alanine metabolism (KEGG)
Propanoate metabolism (KEGG)
Global map (KEGG)
Peroxisome (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
193 355 5cwg (A) 7 173 15.00 0.31 0.33 0.417049 -0.79
216 790 4ksa (A) 10 450 29.00 0 1 0.584595 1.6
244 791 4ksf (A) 36 443 33.00 0 1 0.592547 1.28
456 554 5a2s (A) 929 1025 30.00 0.91 0.23 0.364842 0.55

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_131397)

Species Accession Gene Product
Arabidopsis thaliana AT4G04320   malonyl-CoA decarboxylase
Brugia malayi Bm1_53640   putative malonyl-CoA decarboxylase
Caenorhabditis elegans CELE_F35G12.1   Protein MLCD-1, isoform A
Dictyostelium discoideum DDB_G0290089   hypothetical protein
Homo sapiens 23417   malonyl-CoA decarboxylase
Leishmania braziliensis LbrM.07.0810   malonyl-coa decarboxylase-like protein
Leishmania donovani LdBPK_070820.1   malonyl-coa decarboxylase-like protein
Leishmania infantum LinJ.07.0820   malonyl-coa decarboxylase-like protein
Leishmania major LmjF.07.0730   malonyl-coa decarboxylase-like protein
Leishmania mexicana LmxM.07.0730   malonyl-coa decarboxylase-like protein
Loa Loa (eye worm) LOAG_02000   hypothetical protein
Mus musculus ENSMUSG00000074064   malonyl-CoA decarboxylase
Oryza sativa 4346967   Os09g0394100
Schmidtea mediterranea mk4.003445.04  
Trypanosoma brucei gambiense Tbg972.8.630   malonyl-CoA decarboxylase, mitochondrial precursor, putative
Trypanosoma brucei Tb927.8.1060   malonyl-CoA decarboxylase, mitochondrial precursor, putative
Trypanosoma congolense TcIL3000_8_640   malonyl-CoA decarboxylase, mitochondrial precursor, putative
Trypanosoma cruzi TcCLB.506401.50   malonyl-CoA decarboxylase, mitochondrial precursor, putative
Trypanosoma cruzi TcCLB.509605.10   malonyl-CoA decarboxylase, mitochondrial precursor, putative
Wolbachia endosymbiont of Brugia malayi Wbm0668   malonyl-CoA decarboxylase

Essentiality

LmjF.07.0730 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.1060 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.1060 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.1060 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.1060 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens malonyl-CoA decarboxylase Compounds References
Mus musculus malonyl-CoA decarboxylase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.2033 0.3808 0.5
0.0159 0.368 1
0.0354885 0.298172 1
0.1933 0.3913 1
0.0651 0.2665 0.6221
0.0328 0.3791 1
0.1525 0.2589 1
0.3746 0.3923 1
0.0198 0.3587 1
0.1552 0.3611 1
0.069 0.2838 1
0.1885 0.3869 0.5
0.0198 0.3284 1
0.0697 0.3903 1
0.0323 0.3889 1
0.1945 0.3917 1
0.0542 0.3881 1
0.0495 0.3845 1
0.0365 0.3897 1
0.035 0.3837 1
0.0189 0.38 0.586
0.0375 0.3894 1
0.1503 0.3797 0.5
0.2039 0.3074 1
0.0159 0.3736 0.5
0.0354885 0.298172 1
0.0831 0.2511 1
0.0817 0.3065 1
0.1134 0.3891 1
0.2162 0.3891 1
0.2481 0.3899 0.5
0.4667 0.3906 1
0.0704 0.3883 1
0.1895 0.3917 1
0.1135 0.3896 1
0.459 0.3247 1
0.2693 0.3908 0.5
0.0198 0.3872 0.5
0.0704 0.3841 1
0.0323 0.3889 1
0.3233 0.3914 1
0.3018 0.392 1
0.0325 0.3752 0.5
0.1904 0.3914 1
0.1135 0.3896 1
0.1054 0.3824 0.5
0.1244 0.3576 0.5
0.0953593 0.287388 0.5
0.1987 0.3918 1
0.0198 0.2868 0.5
0.0495 0.3845 1
0.0323 0.3889 1
0.3324 0.3911 1
0.2881 0.3554 0.5
0.1703 0.3898 1
0.0159 0.3673 1
0.2807 0.392 1
0.0496 0.2645 1
0.1023 0.392 1
0.1528 0.3719 1
0.262 0.392 1
0.3324 0.3911 1
0.4148 0.3912 1
0.1812 0.3923 1
0.0506 0.3838 1
0.6585 0.392 1
0.3634 0.3881 0.5
0.3193 0.3923 1
0.036 0.3862 0.5
0.0198 0.3263 1
0.0415 0.3849 1
0.0198 0.3829 1
0.1346 0.3745 0.5
0.188 0.3919 1
0.068 0.3783 1
0.1026 0.3522 0.5
0.139 0.3908 1
0.3018 0.392 1
0.1816 0.3914 1
0.395 0.392 1
0.3983 0.3917 1
0.3814 0.3915 1
0.132 0.3901 1
0.249 0.3904 1
0.0506 0.3842 0.5
0.1552 0.3611 1
0.1544 0.309 1
0.151 0.3921 0.8519
0.1135 0.3896 1
0.0323 0.2696 1
0.0198 0.3633 1
0.3586 0.3922 1
0.035 0.3837 1
0.0525 0.2945 0.5
0.4312 0.3924 1
0.4312 0.3924 1
0.1669 0.3858 1
0.249 0.3904 1
0.1198 0.3819 0.5
0.1808 0.391 1
0.0173 0.3093 1
0.0198 0.334 1
0.611138 0.348736 1
0.0536 0.3881 1
0.1719 0.3906 1
0.0868 0.3682 1
0.0396 0.3614 0.5
0.1696 0.251 1
0.2445 0.3907 1
0.0396 0.3834 1
0.035 0.3837 1
0.0543 0.386 1
0.3193 0.3923 1
0.1787 0.3909 1
0.0159 0.3633 0.5079
0.2119 0.3914 1
0.0122 0.3172 0.5
0.1362 0.3741 1
0.1882 0.3622 1
0.0722 0.3382 1
0.0662 0.3849 1
0.0198 0.3819 0.5
0.0159 0.3673 1
0.2162 0.3891 1
0.2729 0.3924 1
0.0171 0.3241 0.5
0.197 0.386 1
0.0328 0.3791 1
0.0327 0.3459 0.5
0.0163 0.3152 0.5
0.1221 0.3866 1
0.057 0.3758 1
0.0953593 0.287388 0.5
0.0322 0.3873 1
0.3391 0.3918 1
0.1731 0.3897 1
0.1023 0.392 1
0.1626 0.3905 1
0.1135 0.3896 1
0.035 0.3837 1
0.3814 0.3915 1
0.2139 0.3889 0.5
0.0953593 0.287388 0.5
0.1865 0.3334 1
0.0198 0.3883 1
0.0868 0.3682 1
0.0868 0.3682 1
0.1135 0.3896 1
0.0528 0.3857 1
0.1752 0.3881 1
0.073 0.3878 1
0.0259 0.292 0.6049
0.0396 0.3092 1
0.0696 0.3896 0.5
0.1392 0.3911 1
0.0323 0.3889 1
0.0354885 0.298172 1
0.0198 0.3793 1
0.1503 0.3797 0.5
0.025 0.314 0.7454
0.1808 0.391 1
0.3185 0.3899 1
0.0493 0.3561 0.5
0.073 0.3878 1
0.2729 0.3924 1
0.1135 0.3896 1
0.2627 0.39 1
0.1145 0.2738 1
0.0679 0.3786 1
0.1787 0.3909 1
0.0163 0.3584 0.6874
0.0697 0.3903 1
0.3193 0.3923 1
0.069 0.2838 1
0.1875 0.3923 1
0.073 0.3878 1
0.1626 0.3905 1
0.1525 0.2589 1
0.1089 0.3824 0.5
0.0847 0.3669 0.5
0.1699 0.3857 0.5
0.0483 0.2925 1
0.0536 0.3881 1
0.2637 0.3777 1
0.2943 0.392 1
0.2726 0.3803 1
0.1712 0.382 1
0.262 0.392 1
0.0198 0.3756 1
0.1882 0.3622 1
0.0704 0.3883 1
0.0486 0.3734 0.5
0.0517 0.33 0.7251
0.1527 0.3896 1
0.0328 0.3791 1
0.2637 0.3777 1
0.0178 0.254 0.5
0.3018 0.392 1
0.0158 0.3563 1
0.3127 0.3427 1
0.1351 0.3795 1
0.1552 0.3611 1
0.1712 0.382 1
0.0415 0.2505 1
0.0525 0.2945 0.5
0.1013 0.3403 0.5
0.1683 0.3706 0.5
0.1731 0.3897 1
0.2729 0.3924 1
0.2637 0.3777 1
0.2706 0.3919 1
0.0198 0.316 1
0.3972 0.3834 1
0.3018 0.392 1
0.1675 0.3911 1
0.0168 0.3476 1
0.0198 0.3535 0.5
0.0697 0.3903 1
0.3816 0.3592 0.5
0.2303 0.3917 1
0.2445 0.3907 1
0.0163 0.2672 1
0.1522 0.2821 1
0.1071 0.2831 1
0.0642 0.3907 1
0.1209 0.3818 0.5
0.3127 0.3427 1
0.2012 0.3922 1
0.3193 0.3923 1
0.1166 0.3756 0.5
0.1816 0.3914 1
0.146 0.3907 1
0.1544 0.309 1
0.0502 0.3883 1
0.2637 0.3777 1
0.1945 0.3917 1
0.0346 0.3787 1
0.073 0.3878 1
0.0525 0.2945 0.5
0.2637 0.3777 1
0.068 0.3783 1
0.3746 0.3923 1
0.2845 0.3919 1
0.0354885 0.298172 1
0.462 0.3924 1
0.1198 0.3819 0.5
0.0396 0.3666 1
0.0198 0.3202 0.9998
0.2481 0.3899 0.5
0.0676 0.3873 1
0.2026 0.385 0.5
0.151 0.3921 0.8519
0.1619 0.3514 0.5
0.0496 0.2645 1
0.1703 0.3898 1
0.0164 0.2682 1
0.3586 0.3922 1
0.1874 0.3914 1
0.0323 0.3889 1
0.0198 0.2816 1
0.1135 0.3896 1
0.067 0.3895 0.5
1.0026 0.3927 1
0.1463 0.3551 0.5
0.1669 0.3858 1
0.2034 0.3119 1
0.132 0.3901 1
0.0676 0.3873 1
0.3324 0.3911 1
0.2822 0.3926 1
0.0953593 0.287388 0.5
0.1182 0.3897 1
0.0162 0.3222 0.5
0.2706 0.3919 1
0.2818 0.392 1
0.0869 0.3874 1
0.0528 0.3857 1
0.1525 0.2589 1
0.3391 0.3918 1
0.1251 0.3561 0.5
0.0334 0.386 0.5
0.0925 0.3874 1
0.1022 0.3906 1
0.0327 0.3858 0.8689
0.0198 0.3793 1
0.0542 0.3881 1
0.3558 0.3911 1
0.1816 0.3914 1
0.2034 0.3119 1
0.1882 0.3914 1
1.5866 0.3927 1
0.1392 0.3911 1
0.0969 0.3855 1
0.1319 0.3096 1
0.0817 0.3065 1
0.1653 0.3909 1
0.3127 0.3427 1
0.3193 0.3923 1
0.1008 0.3902 1
0.0198 0.33 1
0.0415 0.2505 1
0.2706 0.3919 1
0.0161 0.357 0.5074
0.1022 0.3906 1
0.0979 0.3884 1
0.0415 0.3849 1
0.0817 0.3065 1
0.1714 0.3801 1
0.1375 0.332 1
0.0198 0.3662 0.5
0.0877 0.3859 1
0.1135 0.3896 1
0.1816 0.3914 1
0.0651 0.2665 0.6221
0.3983 0.3917 1
0.0266 0.3043 1
0.1172 0.3908 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LmjF.07.0730 (Leishmania major), malonyl-coa decarboxylase-like protein
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